Michael D Cahalan

Department of Physiology and Biophysics, University of California, Irvine (UCI)

Affiliated withUniversity of California, Irvine (UCI)

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 72	2008

Other Publications

Article	Year
Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. The Journal of biological chemistry\| PubMed ID: 11724775	2002
The ins and outs of polycystin-2 as a calcium release channel. Nature cell biology\| PubMed ID: 11875447	2002
Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science (New York, N.Y.)\| PubMed ID: 12016203	2002
Distinct properties of CRAC and MIC channels in RBL cells. The Journal of general physiology\| PubMed ID: 12149283	2002
Two-photon imaging in intact lymphoid tissue. Advances in experimental medicine and biology\| PubMed ID: 12405205	2002
Two-photon tissue imaging: seeing the immune system in a fresh light. Nature reviews. Immunology\| PubMed ID: 12415310	2002
A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes. The Journal of biological chemistry\| PubMed ID: 12511563	2003
MIC channels are inhibited by internal divalent cations but not ATP. Biophysical journal\| PubMed ID: 12547774	2003
Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12601158	2003
Polyvalent cations as permeant probes of MIC and TRPM7 pores. Biophysical journal\| PubMed ID: 12668438	2003
Real-time imaging of lymphocytes in vivo. Current opinion in immunology\| PubMed ID: 12900266	2003
A stochastic view of lymphocyte motility and trafficking within the lymph node. Immunological reviews\| PubMed ID: 12969316	2003
Regulation of membrane trafficking and subcellular organization of endocytic compartments revealed with FM1-43 in resting and activated human T cells. Experimental cell research\| PubMed ID: 14597416	2003
SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels. The Journal of biological chemistry\| PubMed ID: 14638680	2004
T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14722354	2004
A store-operated calcium channel in Drosophila S2 cells. The Journal of general physiology\| PubMed ID: 14744989	2004
K+ channels as targets for specific immunomodulation. Trends in pharmacological sciences\| PubMed ID: 15120495	2004
Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes. The Journal of experimental medicine\| PubMed ID: 15466619	2004
STOP! In the name of positive selection. Nature immunology\| PubMed ID: 15662438	2005
Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1. The Journal of biological chemistry\| PubMed ID: 15781465	2005
Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS biology\| PubMed ID: 15857154	2005
STIM1, an essential and conserved component of store-operated Ca2+ channel function. The Journal of cell biology\| PubMed ID: 15866891	2005
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature\| PubMed ID: 16208375	2005
Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels. The Journal of general physiology\| PubMed ID: 16260839	2005
Close encounters of the first and second kind: T-DC and T-B interactions in the lymph node. Seminars in immunology\| PubMed ID: 16263308	2005
Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nature immunology\| PubMed ID: 16273098	2005
The sense of place in the immune system. Nature immunology\| PubMed ID: 16550194	2006
Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16751269	2006
Imaging the choreography of lymphocyte trafficking and the immune response. Current opinion in immunology\| PubMed ID: 16765574	2006
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nature chemical biology\| PubMed ID: 16829954	2006
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature\| PubMed ID: 16921385	2006
Molecular basis of the CRAC channel. Cell calcium\| PubMed ID: 17482674	2007
Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17609379	2007
Ca2+ signals in CD4+ T cells during early contacts with antigen-bearing dendritic cells in lymph node. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17641025	2007
Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17675487	2007
Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annual review of immunology\| PubMed ID: 18173372	2008
Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18250319	2008
Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3. The Journal of biological chemistry\| PubMed ID: 18420579	2008
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature\| PubMed ID: 18820677	2008
Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo. PloS one\| PubMed ID: 18820727	2008
Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity\| PubMed ID: 18835197	2008
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation\| PubMed ID: 19380626	2009
STIMulating store-operated Ca(2+) entry. Nature cell biology\| PubMed ID: 19488056	2009
The functional network of ion channels in T lymphocytes. Immunological reviews\| PubMed ID: 19754890	2009
NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20139277	2010
The immunological synapse: a dynamic platform for local signaling. Journal of clinical immunology\| PubMed ID: 20390326	2010
Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20404167	2010
Cell biology. How to STIMulate calcium channels. Science (New York, N.Y.)\| PubMed ID: 20929798	2010
Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells. Immunity\| PubMed ID: 21093319	2010
Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21148796	2011
General approach to adoptive transfer and cell labeling for immunoimaging. Cold Spring Harbor protocols\| PubMed ID: 21285265	2011
Induction of an immune response for imaging antigen-presenting cell/T-cell interactions. Cold Spring Harbor protocols\| PubMed ID: 21285266	2011
In situ lymph node imaging. Cold Spring Harbor protocols\| PubMed ID: 21285267	2011
In vivo lymph node imaging. Cold Spring Harbor protocols\| PubMed ID: 21285268	2011
Immunoimaging: studying immune system dynamics using two-photon microscopy. Cold Spring Harbor protocols\| PubMed ID: 21285279	2011
Imaging transplant rejection: a new view. Nature medicine\| PubMed ID: 21647143	2011
Analysis of transient migration behavior of natural killer cells imaged in situ and in vitro. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 21687858	2011
Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21987804	2011
Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21987805	2011
CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) Î²2, and prevents death-inducing signaling complex formation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22065776	2011