Mira Edgerton

Department of Oral Biology, University at Buffalo

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2018

Other Publications

Article	Year
Salivary histatin 5 and human neutrophil defensin 1 kill Candida albicans via shared pathways. Antimicrobial agents and chemotherapy\| PubMed ID: 11083633	2000
Salivary histatin 5 and its similarities to the other antimicrobial proteins in human saliva. Advances in dental research\| PubMed ID: 11842919	2000
Calcium blocks fungicidal activity of human salivary histatin 5 through disruption of binding with Candida albicans. Journal of dental research\| PubMed ID: 12939362	2003
Uptake of the antifungal cationic peptide Histatin 5 by Candida albicans Ssa2p requires binding to non-conventional sites within the ATPase domain. Molecular microbiology\| PubMed ID: 19006817	2008
Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. The Journal of experimental medicine\| PubMed ID: 19204111	2009
CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity\| PubMed ID: 21435589	2011
Histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins. The Journal of biological chemistry\| PubMed ID: 22033918	2011
Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis. PloS one\| PubMed ID: 23139737	2012
Candida albicans flu1-mediated efflux of salivary histatin 5 reduces its cytosolic concentration and fungicidal activity. Antimicrobial agents and chemotherapy\| PubMed ID: 23380720	2013
Histatin 5 resistance of Candida glabrata can be reversed by insertion of Candida albicans polyamine transporter-encoding genes DUR3 and DUR31. PloS one\| PubMed ID: 23613860	2013
Histatin 5-spermidine conjugates have enhanced fungicidal activity and efficacy as a topical therapeutic for oral candidiasis. Antimicrobial agents and chemotherapy\| PubMed ID: 24247141	2014
Iron-responsive chromatin remodelling and MAPK signalling enhance adhesion in Candida albicans. Molecular microbiology\| PubMed ID: 24889932	2014
How does it kill?: understanding the candidacidal mechanism of salivary histatin 5. Eukaryotic cell\| PubMed ID: 24951439	2014
Iron binding modulates candidacidal properties of salivary histatin 5. Journal of dental research\| PubMed ID: 25365968	2015
Candida albicans Cek1 mitogen-activated protein kinase signaling enhances fungicidal activity of salivary histatin 5. Antimicrobial agents and chemotherapy\| PubMed ID: 25824232	2015
Novel Aggregation Properties of Candida albicans Secreted Aspartyl Proteinase Sap6 Mediate Virulence in Oral Candidiasis. Infection and immunity\| PubMed ID: 25870228	2015
Candida albicans Shed Msb2 and Host Mucins Affect the Candidacidal Activity of Salivary Hst 5. Pathogens (Basel, Switzerland)\| PubMed ID: 26529023	2015
Innate Immunity and Saliva in Candida albicans-mediated Oral Diseases. Journal of dental research\| PubMed ID: 26747422	2016
Signalling mucin Msb2 Regulates adaptation to thermal stress in Candida albicans. Molecular microbiology\| PubMed ID: 26749104	2016
Candida glabrata Binding to Candida albicans Hyphae Enables Its Development in Oropharyngeal Candidiasis. PLoS pathogens\| PubMed ID: 27029023	2016
Human Salivary Protein Histatin 5 Has Potent Bactericidal Activity against ESKAPE Pathogens. Frontiers in cellular and infection microbiology\| PubMed ID: 28261570	2017
Structural Characterization of Histatin 5-Spermidine Conjugates: A Combined Experimental and Theoretical Study. Journal of chemical information and modeling\| PubMed ID: 28586222	2017
Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition. Scientific reports\| PubMed ID: 28588252	2017
An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses. PLoS pathogens\| PubMed ID: 28953977	2017
Fluconazole-Resistant Candida auris Is Susceptible to Salivary Histatin 5 Killing and to Intrinsic Host Defenses. Antimicrobial agents and chemotherapy\| PubMed ID: 29158282	2018
Real-Time Approach to Flow Cell Imaging of Candida albicans Biofilm Development. Journal of fungi (Basel, Switzerland)\| PubMed ID: 29371532	2017
Salivary metals, age, and gender correlate with cultivable oral carriage levels. Journal of oral microbiology\| PubMed ID: 29686781	2018
Methodologies for and evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms. Microbial cell (Graz, Austria)\| PubMed ID: 29992128	2018
Ras1 inactivation increases resistance to phagosomal killing by human neutrophils. Infection and immunity\| PubMed ID: 30249746	2018