Articles by Nathalie De Vocht in JoVE

Multimodal Imaging of Stem Cell Implantation in the Central Nervous System of Mice

JoVE 3906 6/13/2012

Nathalie De Vocht^1,2, Kristien Reekmans¹, Irene Bergwerf², Jelle Praet^1,2, Chloé Hoornaert¹, Debbie Le Blon¹, Jasmijn Daans¹, Zwi Berneman¹, Annemie Van der Linden², Peter Ponsaerts¹

¹Laboratory of Experimental Hematology, University of Antwerp, ²Bio Imaging Lab, University of Antwerp

This article describes an optimized sequence of events for multimodal imaging of cellular grafts in rodent brain using: (i) in vivo bioluminescence and magnetic resonance imaging, and (ii) post mortem histological analysis. Combining these imaging modalities on a single animal allows cellular graft evaluation with high resolution, sensitivity and specificity.