Nicola A. Burgess-Brown

Centre for Medicines Discovery, University of Oxford

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 12	2023

Other Publications

Article	Year
Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study. Protein expression and purification\| PubMed ID: 18289875	2008
High throughput production of recombinant human proteins for crystallography. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18542867	2008
Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell\| PubMed ID: 19167335	2009
High-throughput production of human proteins for crystallization: the SGC experience. Journal of structural biology\| PubMed ID: 20541610	2010
A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation. Nucleic acids research\| PubMed ID: 21059676	2011
Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. Genes & development\| PubMed ID: 21896658	2011
Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation. New biotechnology\| PubMed ID: 22027370	2012
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4. Journal of molecular biology\| PubMed ID: 22575888	2012
The structural basis of ZMPSTE24-dependent laminopathies. Science (New York, N.Y.)\| PubMed ID: 23539603	2013
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23716676	2013
Structural insights into functional overlapping and differentiation among myosin V motors. The Journal of biological chemistry\| PubMed ID: 24097982	2013
Medium-throughput production of recombinant human proteins: ligation-independent cloning. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24203324	2014
Medium-throughput production of recombinant human proteins: protein production in E. coli. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24203325	2014
Medium-throughput production of recombinant human proteins: protein production in insect cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24203326	2014
Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching. Epigenetics & chromatin\| PubMed ID: 25097667	2014
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science (New York, N.Y.)\| PubMed ID: 25766236	2015
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis. Annals of the rheumatic diseases\| PubMed ID: 26209657	2016
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor. MedChemComm\| PubMed ID: 26682034	2014
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. Journal of medicinal chemistry\| PubMed ID: 26741168	2016
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2). Nature structural & molecular biology\| PubMed ID: 27991905	2017
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell chemical biology\| PubMed ID: 28262558	2017
The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery. Essays in biochemistry\| PubMed ID: 29118096	2017
Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design. Cell\| PubMed ID: 30388443	2018
High-Throughput Site-Directed Mutagenesis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 31267458	2019
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Nature communications\| PubMed ID: 31477691	2019
A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature\| PubMed ID: 32499642	2020
Screening and Production of Recombinant Human Proteins: Ligation-Independent Cloning. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 33125643	2021
Screening and Production of Recombinant Human Proteins: Protein Production in E. coli. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 33125644	2021
Screening and Production of Recombinant Human Proteins: Protein Production in Insect Cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 33125645	2021
Expression Screening of Human Integral Membrane Proteins Using BacMam. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 33125646	2021
Structure and activation mechanism of the human liver-type glutaminase GLS2. Biochimie\| PubMed ID: 33746066	2021
Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters. The EMBO journal\| PubMed ID: 34031912	2021
The structural basis of fatty acid elongation by the ELOVL elongases. Nature structural & molecular biology\| PubMed ID: 34117479	2021
Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain. Structure (London, England : 1993)\| PubMed ID: 34233201	2021
Beyond Just Peptide Antigens: The Complex World of Peptide-Based Cancer Vaccines. Frontiers in immunology\| PubMed ID: 34276688	2021
Identification, mapping and relative quantitation of SARS-CoV-2 Spike glycopeptides by Mass-Retention Time Fingerprinting. Communications biology\| PubMed ID: 34345007	2021
FAS2FURIOUS: Moderate-Throughput Secreted Expression of Difficult Recombinant Proteins in S2 Cells. Frontiers in bioengineering and biotechnology\| PubMed ID: 35600892	2022
Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain. Nature communications\| PubMed ID: 35840580	2022