P. Richard Harrigan

Laboratory Program, BC Centre for Excellence in HIV/AIDS

Affiliated withBC Centre for Excellence in HIV/AIDS

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 20	2010
Publication title	2011

Other Publications

Article	Year
The T cell receptor V beta repertoire shows little change during treatment interruption-related viral rebound in chronic HIV infection. AIDS (London, England)\| PubMed ID: 11807314	2002
Extreme responses to climate change in Antarctic lakes. Science (New York, N.Y.)\| PubMed ID: 11809962	2002
Extent of cross-resistance between agents used to treat human immunodeficiency virus type 1 infection in clinically derived isolates. Antimicrobial agents and chemotherapy\| PubMed ID: 11850286	2002
Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients. The New England journal of medicine\| PubMed ID: 11893792	2002
Prevalence and response to antiretroviral therapy of non-B subtypes of HIV in antiretroviral-naive individuals in British Columbia. Antiviral therapy\| PubMed ID: 12008785	2002
A mutation in the 3' region of the human immunodeficiency virus type 1 reverse transcriptase (Y318F) associated with nonnucleoside reverse transcriptase inhibitor resistance. Journal of virology\| PubMed ID: 12050397	2002
No association between GB virus-C viremia and virological or immunological failure after starting initial antiretroviral therapy. AIDS (London, England)\| PubMed ID: 12351953	2002
Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response. AIDS (London, England)\| PubMed ID: 12545080	2003
Is there a baseline CD4 cell count that precludes a survival response to modern antiretroviral therapy? AIDS (London, England)\| PubMed ID: 12646794	2003
Prevalence and clinical implications of insertions in the HIV-1 p6Gag N-terminal region in drug-naive individuals initiating antiretroviral therapy. Antiviral therapy\| PubMed ID: 12741620	2003
Mitochondrial:nuclear DNA ratios in peripheral blood cells from human immunodeficiency virus (HIV)-infected patients who received selected HIV antiretroviral drug regimens. The Journal of infectious diseases\| PubMed ID: 12792876	2003
Prolonged retention of drug resistance mutations and rapid disease progression in the absence of therapy after primary HIV infection. AIDS (London, England)\| PubMed ID: 12819530	2003
Rates of disease progression among human immunodeficiency virus-infected persons initiating multiple-drug rescue therapy. The Journal of infectious diseases\| PubMed ID: 12825182	2003
Antiretroviral concentrations in untimed plasma samples predict therapy outcome in a population with advanced disease. The Journal of infectious diseases\| PubMed ID: 12898441	2003
Mitochondrial toxicity in the era of HAART: evaluating venous lactate and peripheral blood mitochondrial DNA in HIV-infected patients taking antiretroviral therapy. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 14562863	2003
对生存的 CD4 + 细胞计数时启动高活性抗逆转录病毒治疗&#x7684... Annals of internal medicine\| PubMed ID: 14623618	2003
Higher baseline levels of plasma human immunodeficiency virus type 1 RNA are associated with increased mortality after initiation of triple-drug antiretroviral therapy. The Journal of infectious diseases\| PubMed ID: 14624366	2003
Insulin-like growth factor-1 protects ischemic murine myocardium from ischemia/reperfusion associated injury. Critical care (London, England)\| PubMed ID: 14624693	2003
Modest decreases in NNRTI susceptibility do not influence virological outcome in patients receiving initial NNRTI-containing triple therapy. Antiviral therapy\| PubMed ID: 14640386	2003
Nucleoside-related mitochondrial toxicity among HIV-infected patients receiving antiretroviral therapy: insights from the evaluation of venous lactic acid and peripheral blood mitochondrial ... Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 14986278	2004
The impact of adherence on CD4 cell count responses among HIV-infected patients. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 15076240	2004
Clinical and immunological impact of HIV envelope V3 sequence variation after starting initial triple antiretroviral therapy. AIDS (London, England)\| PubMed ID: 15090786	2004
Are untimed antiretroviral drug levels useful predictors of adherence behavior? AIDS (London, England)\| PubMed ID: 15090840	2004
Antiretroviral resistance among HIV-infected persons who have died in British Columbia, in the era of modern antiretroviral therapy. The Journal of infectious diseases\| PubMed ID: 15216463	2004
2004: which HIV-1 drug resistance mutations are common in clinical practice? AIDS reviews\| PubMed ID: 15332433	2004
Using baseline CD4 cell count and plasma HIV RNA to guide the initiation of highly active antiretroviral therapy. Revista de investigaciÃ³n clÃnica; organo del Hospital de Enfermedades de la NutriciÃ³n\| PubMed ID: 15377076	2004
Simplification of therapeutic drug monitoring for twice-daily regimens of lopinavir/ritonavir for HIV infection. Therapeutic drug monitoring\| PubMed ID: 15385834	2004
Predictive value of HIV-1 protease genotype and virtual phenotype on the virological response to lopinavir/ritonavir-containing salvage regimens. Antiviral therapy\| PubMed ID: 15456091	2004
Earlier initiation of highly active antiretroviral therapy does not protect against the deleterious effects of non-adherence. AIDS (London, England)\| PubMed ID: 15622322	2004
Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy. The Journal of infectious diseases\| PubMed ID: 15633092	2005
Changes in lipids over twelve months after initiating protease inhibitor therapy among persons treated for HIV/AIDS. Lipids in health and disease\| PubMed ID: 15705191	2005
Why are baseline HIV RNA levels 100,000 copies/mL or greater associated with mortality after the initiation of antiretroviral therapy? Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 15735446	2005
Comparable pharmacokinetics of generic indinavir (Inhibisam) versus brand indinavir (Crixivan) when boosted with ritonavir. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 15735458	2005
HIV-1 drug resistance: degree of underestimation by a cross-sectional versus a longitudinal testing approach. The Journal of infectious diseases\| PubMed ID: 15776380	2005
Rare mutations at codon 103 of HIV-1 reverse transcriptase can confer resistance to non-nucleoside reverse transcriptase inhibitors. AIDS (London, England)\| PubMed ID: 15802972	2005
No inherent association between minor mutations in HIV protease at baseline and selection of the L90M mutation at the time of the first virological failure. The Journal of infectious diseases\| PubMed ID: 15838807	2005
Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: results of a global collaboration. PLoS medicine\| PubMed ID: 15839752	2005
When to initiate antiretroviral therapy in HIV-1-infected adults: a review for clinicians and patients. The Lancet infectious diseases\| PubMed ID: 15978527	2005
Rates of antiretroviral resistance among HIV-infected patients with and without a history of injection drug use. AIDS (London, England)\| PubMed ID: 15990572	2005
Molecular and clinical epidemiology of CXCR4-using HIV-1 in a large population of antiretroviral-naive individuals. The Journal of infectious diseases\| PubMed ID: 15995960	2005
HIV-1 genetic diversity in antenatal cohort, Canada. Emerging infectious diseases\| PubMed ID: 16102312	2005
Short communication. Association of the CCR5delta32 mutation with clinical response and >5-year survival following initiation of first triple antiretroviral regimen. Antiviral therapy\| PubMed ID: 16312181	2005
Utilization of a liver allograft from a hepatitis B surface antigen positive donor. Transplantation\| PubMed ID: 16421489	2006
The direct costs of HIV/AIDS care. The Lancet infectious diseases\| PubMed ID: 16500598	2006
Adherence-resistance relationships for protease and non-nucleoside reverse transcriptase inhibitors explained by virological fitness. AIDS (London, England)\| PubMed ID: 16511415	2006
Exploring mitochondrial nephrotoxicity as a potential mechanism of kidney dysfunction among HIV-infected patients on highly active antiretroviral therapy. Antiviral therapy\| PubMed ID: 16518963	2006
Impact of baseline viral load and adherence on survival of HIV-infected adults with baseline CD4 cell counts > or = 200 cells/microl. AIDS (London, England)\| PubMed ID: 16691062	2006
HIV therapy, hepatitis C virus infection, antibiotics and obesity, a mitochondria killer mix? AIDS (London, England)\| PubMed ID: 16816571	2006
HIV VprR77Q mutation does not influence clinical response of individuals initiating highly active antiretroviral therapy. AIDS research and human retroviruses\| PubMed ID: 16831085	2006
The impact of human genetic variation on HIV disease in the era of HAART. AIDS reviews\| PubMed ID: 16848275	2006
The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic. Lancet\| PubMed ID: 16890841	2006
Fatal postlymphoma chemotherapy hepatitis B reactivation secondary to the emergence of a YMDD mutant strain with lamivudine resistance in a noncirrhotic patient. American journal of hematology\| PubMed ID: 16937392	2006
Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremia. The Journal of infectious diseases\| PubMed ID: 16960780	2006
Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART. PLoS medicine\| PubMed ID: 16984218	2006
A simple, dynamic measure of antiretroviral therapy adherence predicts failure to maintain HIV-1 suppression. The Journal of infectious diseases\| PubMed ID: 16991085	2006
Determining human immunodeficiency virus coreceptor use in a clinical setting: degree of correlation between two phenotypic assays and a bioinformatic model. Journal of clinical microbiology\| PubMed ID: 17122004	2007
Structural descriptors of gp120 V3 loop for the prediction of HIV-1 coreceptor usage. PLoS computational biology\| PubMed ID: 17397254	2007
Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy. AIDS (London, England)\| PubMed ID: 17413689	2007
Effects of human leukocyte antigen class I genetic parameters on clinical outcomes and survival after initiation of highly active antiretroviral therapy. The Journal of infectious diseases\| PubMed ID: 17471440	2007
A simple screening approach to reduce B*5701-associated abacavir hypersensitivity on the basis of sequence variation in HIV reverse transcriptase. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 17479950	2007
HIV-1 drug resistance surveillance using dried whole blood spots. Antiviral therapy\| PubMed ID: 17503754	2007
Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1. PLoS pathogens\| PubMed ID: 17616974	2007
Determinants of nevirapine hypersensitivity and its effect on the association between hepatitis C status and mortality in antiretroviral drug-naive HIV-positive patients. AIDS (London, England)\| PubMed ID: 17630551	2007
A 21-base pair insertion/duplication at codon 69 of the HIV type 1 reverse transcriptase in a patient undergoing multiple nucleoside therapy. AIDS research and human retroviruses\| PubMed ID: 17678473	2007
Current V3 genotyping algorithms are inadequate for predicting X4 co-receptor usage in clinical isolates. AIDS (London, England)\| PubMed ID: 17721088	2007
Predicting HIV coreceptor usage on the basis of genetic and clinical covariates. Antiviral therapy\| PubMed ID: 18018768	2007
Transmission of drug-resistant HIV-1 from an infected individual to a caregiver. Antiviral therapy\| PubMed ID: 18018773	2007
N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance. PLoS medicine\| PubMed ID: 18052601	2007
Tenofovir-based rescue therapy for advanced liver disease in 6 patients coinfected with HIV and hepatitis B virus and receiving lamivudine. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 18181733	2008
CD4-dependent characteristics of coreceptor use and HIV type 1 V3 sequence in a large population of therapy-naive individuals. AIDS research and human retroviruses\| PubMed ID: 18240966	2008
Is nevirapine-based therapy discontinuation in hepatitis C co-infected patients a more important mortality determinant than hypersensitivity: authors' reply. AIDS (London, England)\| PubMed ID: 18301076	2008
Determination of clinically relevant cutoffs for HIV-1 phenotypic resistance estimates through a combined analysis of clinical trial and cohort data. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 18360290	2008
Increased resilience to the development of drug resistance with modern boosted protease inhibitor-based highly active antiretroviral therapy. The Journal of infectious diseases\| PubMed ID: 18498238	2008
Expanded access to highly active antiretroviral therapy: a potentially powerful strategy to curb the growth of the HIV epidemic. The Journal of infectious diseases\| PubMed ID: 18498241	2008
Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms. The Journal of biological chemistry\| PubMed ID: 18547911	2008
Human leukocyte antigen-specific polymorphisms in HIV-1 Gag and their association with viral load in chronic untreated infection. AIDS (London, England)\| PubMed ID: 18580606	2008
Perinatal exposure to antiretroviral therapy is associated with increased blood mitochondrial DNA levels and decreased mitochondrial gene expression in infants. The Journal of infectious diseases\| PubMed ID: 18684095	2008
HIV coreceptor phenotyping in the clinical setting. AIDS reviews\| PubMed ID: 18820716	2008
Bayesian network analyses of resistance pathways against efavirenz and nevirapine. AIDS (London, England)\| PubMed ID: 18832874	2008
The relationship between resistance and adherence in drug-naive individuals initiating HAART is specific to individual drug classes. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 18845950	2008
Silent mutations are selected in HIV-1 reverse transcriptase and affect enzymatic efficiency. AIDS (London, England)\| PubMed ID: 19005273	2008
Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag. PLoS computational biology\| PubMed ID: 19023406	2008
HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers. Journal of virology\| PubMed ID: 19153230	2009
Lopinavir/ritonavir pharmacokinetics in a substitution of high-dose soft-gelatin capsule to tablet formulation. Journal of clinical pharmacology\| PubMed ID: 19179294	2009
Association between HIV-1 RNA level and CD4 cell count among untreated HIV-infected individuals. American journal of public health\| PubMed ID: 19218172	2009
Adaptation of HIV-1 to human leukocyte antigen class I. Nature\| PubMed ID: 19242411	2009
Longitudinal community plasma HIV-1 RNA concentrations and incidence of HIV-1 among injecting drug users: prospective cohort study. BMJ (Clinical research ed.)\| PubMed ID: 19406887	2009
Detection of low-frequency pretherapy chemokine (CXC motif) receptor 4 (CXCR4)-using HIV-1 with ultra-deep pyrosequencing. AIDS (London, England)\| PubMed ID: 19424056	2009
HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. PloS one\| PubMed ID: 19690614	2009
Improved virological outcomes in British Columbia concomitant with decreasing incidence of HIV type 1 drug resistance detection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 19951169	2010
Phylogenetic analysis of population-based and deep sequencing data to identify coevolving sites in the nef gene of HIV-1. Molecular biology and evolution\| PubMed ID: 19955476	2010
Epidemiology of treatment failure: a focus on recent trends. Current opinion in HIV and AIDS\| PubMed ID: 20048712	2009
Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences. The Journal of experimental medicine\| PubMed ID: 20065065	2010
Connection domain mutations in treatment-experienced patients in the OPTIMA trial. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 20130473	2010
Regional differences in rates of HIV-1 viral load monitoring in Canada: Insights and implications for antiretroviral care in high income countries. BMC infectious diseases\| PubMed ID: 20184766	2010
HIV drug resistance over the long haul. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 20353363	2010
Improved detection of CXCR4-using HIV by V3 genotyping: application of population-based and "deep" sequencing to plasma RNA and proviral DNA. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 20512044	2010
HIV antiviral drug resistance: patient comprehension. AIDS care\| PubMed ID: 20635245	2010
Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study. Lancet\| PubMed ID: 20638713	2010
Epidemiology of antiretroviral multiclass resistance. American journal of epidemiology\| PubMed ID: 20667931	2010
Population-based V3 genotypic tropism assay: a retrospective analysis using screening samples from the A4001029 and MOTIVATE studies. AIDS (London, England)\| PubMed ID: 20736814	2010
Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection. Journal of virology\| PubMed ID: 20810731	2010
Risk of viral failure declines with duration of suppression on highly active antiretroviral therapy irrespective of adherence level. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 20838225	2010
Improved prediction of HIVâ€1 coreceptor usage with sequence information from the second hypervariable loop of gp120. The Journal of infectious diseases\| PubMed ID: 20874088	2010
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science (New York, N.Y.)\| PubMed ID: 21051598	2010
In vitro selection of clinically relevant bevirimat resistance mutations revealed by "deep" sequencing of serially passaged, quasispecies-containing recombinant HIV-1. Journal of clinical microbiology\| PubMed ID: 21084518	2011
Genotypic tropism testing: evidence-based or leap of faith? AIDS (London, England)\| PubMed ID: 21099667	2011
The evolutionary analysis of emerging low frequency HIV-1 CXCR4 using variants through time--an ultra-deep approach. PLoS computational biology\| PubMed ID: 21187908	2010
Deep sequencing to infer HIV-1 co-receptor usage: application to three clinical trials of maraviroc in treatment-experienced patients. The Journal of infectious diseases\| PubMed ID: 21288824	2011
"Dynamic range" of inferred phenotypic HIV drug resistance values in clinical practice. PloS one\| PubMed ID: 21390218	2011
Mutations in gp41 are correlated with coreceptor tropism but do not improve prediction methods substantially. Antiviral therapy\| PubMed ID: 21555814	2011
Viral load testing in a resource-limited setting: quality control is critical. Journal of the International AIDS Society\| PubMed ID: 21569393	2011
Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing. PLoS pathogens\| PubMed ID: 21731496	2011
Measuring enzymatic HIV-1 susceptibility to two reverse transcriptase inhibitors as a rapid and simple approach to HIV-1 drug-resistance testing. PloS one\| PubMed ID: 21799767	2011
Dates of HIV infection can be estimated for seroprevalent patients by coalescent analysis of serial next-generation sequencing data. AIDS (London, England)\| PubMed ID: 21832936	2011
Deep V3 sequencing for HIV type 1 tropism in treatment-naive patients: a reanalysis of the MERIT trial of maraviroc. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 21890778	2011
Blood mitochondrial DNA mutations in HIV-infected women and their infants exposed to highly active antiretroviral therapy during pregnancy. AIDS (London, England)\| PubMed ID: 22269971	2012