Petra Schwille

Petra Schwille

Department of Cellular and Molecular Biophysics, Max-Planck-Institut für Biochemie

Affiliated withMax-Planck-Institut für BiochemieMax Planck Institute of Biochemistry

Research Area

Biography

Petra Schwille is Director at the Max Planck Institute of Biochemistry in Martinsried near Munich, Germany, and Honorary Professor at the LMU Munich. She studied physics and philosophy in Stuttgart and Göttingen, and graduated 1993 with Diploma in Physics at the Georg August University, Göttingen. She obtained her Ph.D. in 1996 from the TU Braunschweig, with a thesis on Fluorescence (Cross-)Correlation Spectroscopy, performed at the MPI for Biophysical Chemistry, Göttingen. After a postdoctoral stay at Cornell University, Ithaca, NY, she returned to the MPI Göttingen as a research group leader. In 2002, she accepted a Chair of Biophysics at the newly established BIOTEC center of the U Dresden. Since 2012, she is heading the department Cellular and Molecular Biophysics at the MPI of Biochemistry.

Petra Schwille’s scientific interests range from single molecule biophysics to the synthetic biology of reconstituted systems. In the last years, her department has been engaged in several national and international research initiatives aiming at the bottom-up design of minimal living cells, eventually helping to elucidate fundamental questions about the origin of life.

Her work has been awarded with several prestigious prizes, among them the Gottfried Wilhelm Leibniz Prize of the German Research Foundation in 2010 and the Braunschweig Research Prize in 2011. She is member of the German National Academy of Sciences (Leopoldina), the National Academy of Science and Engineering (acatech), the Berlin-Brandenburg Academy of Sciences and Humanties (BBAW), and the European Molecular Biology Organization (EMBO), as well as Honorary Fellow of the Royal Microscopical Society (2015) and the Biophysical Society (2017).

JoVE Journal Publications

ArticleTotal : 4
Year
<em>In Vitro</em> Reconstitution of Self-Organizing Protein Patterns on Supported Lipid Bilayers
Publication title

Cited by 32

2018
2021
2022
2025

Other Publications

Article
Year
Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells.

Nucleic acids research| PubMed ID: 18842624

2008
2009
Minimal systems to study membrane-cytoskeleton interactions.

Current opinion in biotechnology| PubMed ID: 22503237

2012
Towards a bottom-up reconstitution of bacterial cell division.

Trends in cell biology| PubMed ID: 23067680

2012
2013
2013
Photoconversion of bodipy-labeled lipid analogues.

Chembiochem : a European journal of chemical biology| PubMed ID: 23512865

2013
2013
The design of MACs (minimal actin cortices).

Cytoskeleton (Hoboken, N.J.)| PubMed ID: 24039068

2013
Propagation of MinCDE waves on free-standing membranes.

Environmental microbiology| PubMed ID: 24118679

2013
2013
Bacterial cell division: a swirling ring to rule them all?

Current biology : CB| PubMed ID: 24556438

2014
MinCDE exploits the dynamic nature of FtsZ filaments for its spatial regulation.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 24707052

2014
2014
2014
2014
2014
2014
2014
2015
Amphipathic DNA origami nanoparticles to scaffold and deform lipid membrane vesicles.

Angewandte Chemie (International ed. in English)| PubMed ID: 25882792

2015
2015
2015
Jump-starting life? Fundamental aspects of synthetic biology.

The Journal of cell biology| PubMed ID: 26323686

2015
2015
2015
Pattern formation on membranes and its role in bacterial cell division.

Current opinion in cell biology| PubMed ID: 26915065

2016
2016
2016
Protein Patterns and Oscillations on Lipid Monolayers and in Microdroplets.

Angewandte Chemie (International ed. in English)| PubMed ID: 27465495

2016
2016
Optical Control of Lipid Rafts with Photoswitchable Ceramides.

Journal of the American Chemical Society| PubMed ID: 27626130

2016
2016
Transport efficiency of membrane-anchored kinesin-1 motors depends on motor density and diffusivity.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 27803325

2016
2017
2017
2017
2017
Revolving around constriction by ESCRT-III.

Nature cell biology| PubMed ID: 28659638

2017
2017
Biology and the art of abstraction.

Biophysical reviews| PubMed ID: 28756511

2017
2018
Optical Control of a Biological Reaction-Diffusion System.

Angewandte Chemie (International ed. in English)| PubMed ID: 29266672

2018
Membrane sculpting by curved DNA origami scaffolds.

Nature communications| PubMed ID: 29476101

2018
There and back again: from the origin of life to single molecules.

European biophysics journal : EBJ| PubMed ID: 29569181

2018
FCS Analysis of Protein Mobility on Lipid Monolayers.

Biophysical journal| PubMed ID: 29605081

2018
Reverse and forward engineering of protein pattern formation.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences| PubMed ID: 29632258

2018
2018
MinE conformational switching confers robustness on self-organized Min protein patterns.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 29666276

2018
2018
MaxSynBio - Avenues towards creating cells from the bottom up.

Angewandte Chemie (International ed. in English)| PubMed ID: 29749673

2018
2018
Control of Membrane Binding and Diffusion of Cholesteryl-Modified DNA Origami Nanostructures by DNA Spacers.

Langmuir : the ACS journal of surfaces and colloids| PubMed ID: 30253101

2018
2018
Beating Vesicles: Encapsulated Protein Oscillations Cause Dynamic Membrane Deformations.

Angewandte Chemie (International ed. in English)| PubMed ID: 30270475

2018
2018
2018
2019
2018
Photo-Induced Depletion of Binding Sites in DNA-PAINT Microscopy.

Molecules (Basel, Switzerland)| PubMed ID: 30513691

2018
2018
2019
More from less - bottom-up reconstitution of cell biology.

Journal of cell science| PubMed ID: 30718262

2019
2019
2019
2019
Temperature-sensitive protein expression in protocells.

Chemical communications (Cambridge, England)| PubMed ID: 31094370

2019
Manfred Eigen (1927-2019).

Angewandte Chemie (International ed. in English)| PubMed ID: 31124258

2019
2019
2019
Bottom-up synthetic biology: reconstitution in space and time.

Current opinion in biotechnology| PubMed ID: 31176995

2019
Fluorescence Correlation Spectroscopy to Examine Protein-Lipid Interactions in Membranes.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 31218628

2019
The E. coli MinCDE system in the regulation of protein patterns and gradients.

Cellular and molecular life sciences : CMLS| PubMed ID: 31317204

2019
Reconstitution and Coupling of DNA Replication and Segregation in a Biomimetic System.

Chembiochem : a European journal of chemical biology| PubMed ID: 31344304

2019
2019
Toward Absolute Molecular Numbers in DNA-PAINT.

Nano letters| PubMed ID: 31535868

2019
2019
2019
Shaping Giant Membrane Vesicles in 3D-Printed Protein Hydrogel Cages.

Small (Weinheim an der Bergstrasse, Germany)| PubMed ID: 32105403

2020
2020
2021
2020
2020
2019
2019
2020
FtsZ Reorganization Facilitates Deformation of Giant Vesicles in Microfluidic Traps*.

Angewandte Chemie (International ed. in English)| PubMed ID: 32735732

2020
Fine-Tuning Protein Self-Organization by Orthogonal Chemo-Optogenetic Tools.

Angewandte Chemie (International ed. in English)| PubMed ID: 33155720

2021
Non-Equilibrium Large-Scale Membrane Transformations Driven by MinDE Biochemical Reaction Cycles.

Angewandte Chemie (International ed. in English)| PubMed ID: 33285025

2021
2021
Division in synthetic cells.

Emerging topics in life sciences| PubMed ID: 33523162

2019
Protein Reconstitution Inside Giant Unilamellar Vesicles.

Annual review of biophysics| PubMed ID: 33667121

2021
2021
Reconstitution of contractile actomyosin rings in vesicles.

Nature communications| PubMed ID: 33859190

2021
2021
2021
2021
2021
2021
Hydration Layer of Only a Few Molecules Controls Lipid Mobility in Biomimetic Membranes.

Journal of the American Chemical Society| PubMed ID: 34342967

2021
Self-organized protein patterns: The MinCDE and ParABS systems.

Current opinion in cell biology| PubMed ID: 34399108

2021
2021
2021
Hidden protein functions and what they may teach us.

Trends in cell biology| PubMed ID: 34654605

2021
Design Features to Accelerate the Higher-Order Assembly of DNA Origami on Membranes.

The journal of physical chemistry. B| PubMed ID: 34818013

2021
CTP-controlled liquid-liquid phase separation of ParB.

Journal of molecular biology| PubMed ID: 34902429

2022
PyCorrFit-generic data evaluation for fluorescence correlation spectroscopy.

Bioinformatics (Oxford, England)| PubMed ID: 24825612

2014
2014
2015
2021
2022
2022
Dendrimersome Synthetic Cells Harbor Cell Division Machinery of Bacteria.

Advanced materials (Deerfield Beach, Fla.)| PubMed ID: 35579491

2022
2022
2022
2023
2022
2022
Prebiotic Foam Environments to Oligomerize and Accumulate RNA.

Chembiochem : a European journal of chemical biology| PubMed ID: 36354762

2022
2021
Regulating DNA-Hybridization Using a Chemically Fueled Reaction Cycle.

Journal of the American Chemical Society| PubMed ID: 36442850

2022
2023
MipZ caps the plus-end of FtsZ polymers to promote their rapid disassembly.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 36490318

2022
2023
2023
2023
2023
Binding and Characterization of DNA Origami Nanostructures on Lipid Membranes.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 37166721

2023
2023
2023
2023
2023
Present and future of synthetic cell development.

Nature reviews. Molecular cell biology| PubMed ID: 38102450

2024
2024
Protein-Assisted Large-Scale Assembly and Differential Patterning of DNA Origami Lattices.

Small (Weinheim an der Bergstrasse, Germany)| PubMed ID: 38229553

2024
2024
2024
2024
2024
2025
Polyproline-Polyornithine Diblock Copolymers with Inherent Mitochondria Tropism.

Advanced materials (Deerfield Beach, Fla.)| PubMed ID: 39797465

2025
2025
2025