Richard D. Leapman

Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institutes of Health

Affiliated withNational Institutes of Health

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2023

Other Publications

Article	Year
Activity-dependent calcium sequestration in dendrites of hippocampal neurons in brain slices. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 9348342	1997
Stimulus-secretion coupling in neurohypophysial nerve endings: a role for intravesicular sodium? Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10077662	1999
Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11069287	2000
Multiple modes of calcium-induced calcium release in sympathetic neurons II: a [Ca2+](i)- and location-dependent transition from endoplasmic reticulum Ca accumulation to net Ca release. The Journal of general physiology\| PubMed ID: 11429447	2001
Oligomeric structure of virion-associated and soluble forms of the simian immunodeficiency virus envelope protein in the prefusion activated conformation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11752436	2001
Oligomeric structure of the human immunodeficiency virus type 1 envelope protein on the virion surface. Journal of virology\| PubMed ID: 12097599	2002
A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12481027	2002
Mass distribution and spatial organization of the linear bacterial motor of Spiroplasma citri R8A2. Journal of bacteriology\| PubMed ID: 12618463	2003
Promoting trimerization of soluble human immunodeficiency virus type 1 (HIV-1) Env through the use of HIV-1/simian immunodeficiency virus chimeras. Journal of virology\| PubMed ID: 14963123	2004
Organization of designed nanofibrils assembled from alpha-helical peptides as determined by electron microscopy. Journal of peptide science : an official publication of the European Peptide Society\| PubMed ID: 15160841	2004
Novel techniques in electron microscopy. Current opinion in neurobiology\| PubMed ID: 15464893	2004
Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science (New York, N.Y.)\| PubMed ID: 15653506	2005
Mass of the postsynaptic density and enumeration of three key molecules. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16061821	2005
Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16777967	2006
Evaluation of bioreactor-cultivated bone by magnetic resonance microscopy and FTIR microspectroscopy. Bone\| PubMed ID: 17174620	2007
Localizing specific elements bound to macromolecules by EFTEM. Methods in cell biology\| PubMed ID: 17327176	2007
Protein oxidation implicated as the primary determinant of bacterial radioresistance. PLoS biology\| PubMed ID: 17373858	2007
RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose. The Journal of endocrinology\| PubMed ID: 17951542	2007
Organization of the core structure of the postsynaptic density. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18326622	2008
Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19015532	2008
Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells. Journal of translational medicine\| PubMed ID: 19094226	2008
Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS nano\| PubMed ID: 19236065	2009
Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19376973	2009
Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors. Journal of translational medicine\| PubMed ID: 19549317	2009
Influence of melanosome dynamics on melanoma drug sensitivity. Journal of the National Cancer Institute\| PubMed ID: 19704071	2009
Nanoscale 3D cellular imaging by axial scanning transmission electron tomography. Nature methods\| PubMed ID: 19718033	2009
Imaging the distribution of individual platinum-based anticancer drug molecules attached to single-wall carbon nanotubes. Nanomedicine (London, England)\| PubMed ID: 19839812	2009
Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133720	2010
Dual-axis electron tomography of biological specimens: Extending the limits of specimen thickness with bright-field STEM imaging. Journal of structural biology\| PubMed ID: 21055473	2011
Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice. Nanomedicine (London, England)\| PubMed ID: 21143032	2010
PSD-95 is required to sustain the molecular organization of the postsynaptic density. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21525273	2011
Combining portable Raman probes with nanotubes for theranostic applications. Theranostics\| PubMed ID: 21769298	2011
Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI. Nanoscale\| PubMed ID: 22064945	2011
Synthesis, characterization, and direct intracellular imaging of ultrasmall and uniform glutathione-coated gold nanoparticles. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 22517616	2012
Nuclear mapping of nanodrug delivery systems in dynamic cellular environments. ACS nano\| PubMed ID: 22540867	2012
Direct visualization of CaMKII at postsynaptic densities by electron microscopy tomography. The Journal of comparative neurology\| PubMed ID: 22627922	2012
Development and application of STEM for the biological sciences. Ultramicroscopy\| PubMed ID: 22749213	2012
Aggregation and fibril morphology of the Arctic mutation of Alzheimer's AÎ² peptide by CD, TEM, STEM and in situ AFM. Journal of structural biology\| PubMed ID: 22750418	2012
Mass mapping of amyloid fibrils in the electron microscope using STEM imaging. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23086877	2013
Elemental mapping by electron energy loss spectroscopy in biology. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23086878	2013
Cryo-electron tomography of the magnetotactic vibrio Magnetovibrio blakemorei: insights into the biomineralization of prismatic magnetosomes. Journal of structural biology\| PubMed ID: 23246783	2013
Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy. Angewandte Chemie (International ed. in English)\| PubMed ID: 24318645	2013
A structural framework for a near-minimal form of life: mass and compositional analysis of the helical mollicute Spiroplasma melliferum BC3. PloS one\| PubMed ID: 24586297	2014
Targeted therapeutic nanotubes influence the viscoelasticity of cancer cells to overcome drug resistance. ACS nano\| PubMed ID: 24708375	2014
Passive diffusion as a mechanism underlying ribbon synapse vesicle release and resupply. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24990916	2014
Self-organized Mn-Block Copolymer Complexes and Their Use for MR Imaging of Biological Processes. Journal of materials chemistry. B\| PubMed ID: 25364506	2014
Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States. PloS one\| PubMed ID: 26565809	2015
PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic density. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26604311	2015
STEM tomography reveals that the canalicular system and α-granules remain separate compartments during early secretion stages in blood platelets. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 26663480	2016
Biointeractions of ultrasmall glutathione-coated gold nanoparticles: effect of small size variations. Nanoscale\| PubMed ID: 26934984	2016
Compressed Sensing Electron Tomography for Determining Biological Structure. Scientific reports\| PubMed ID: 27291259	2016
Physicochemical characterization of ferumoxytol, heparin and protamine nanocomplexes for improved magnetic labeling of stem cells. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 27520728	2017
Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures. Platelets\| PubMed ID: 27753523	2017
Tri-stimuli-responsive biodegradable theranostics for mild hyperthermia enhanced chemotherapy. Biomaterials\| PubMed ID: 28254692	2017
PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology. Scientific reports\| PubMed ID: 28256580	2017
Application of EELS and EFTEM to the life sciences enabled by the contributions of Ondrej Krivanek. Ultramicroscopy\| PubMed ID: 28258873	2017
Cells containing aragonite crystals mediate responses to gravity in Trichoplax adhaerens (Placozoa), an animal lacking neurons and synapses. PloS one\| PubMed ID: 29342202	2018
Comparison of 3D cellular imaging techniques based on scanned electron probes: Serial block face SEM vs. Axial bright-field STEM tomography. Journal of structural biology\| PubMed ID: 29408702	2018
Dotted Core-Shell Nanoparticles for T -Weighted MRI of Tumors. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 29972604	2018
Biological serial block face scanning electron microscopy at improved z-resolution based on Monte Carlo model. Scientific reports\| PubMed ID: 30154532	2018
SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets. Blood advances\| PubMed ID: 30401752	2018
Identification of PSD-95 in the Postsynaptic Density Using MiniSOG and EM Tomography. Frontiers in neuroanatomy\| PubMed ID: 30581381	2018
Quantitative method for estimating stain density in electron microscopy of conventionally prepared biological specimens. Journal of microscopy\| PubMed ID: 31994199	2020
Determination of secretory granule maturation times in pancreatic islet β-cells by serial block-face electron microscopy. Journal of structural biology\| PubMed ID: 32736074	2020
Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1. Cell reports\| PubMed ID: 33053337	2020
Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates. Communications biology\| PubMed ID: 34531522	2021
Palmitoylation of A-kinase anchoring protein 79/150 modulates its nanoscale organization, trafficking, and mobility in postsynaptic spines. Frontiers in synaptic neuroscience\| PubMed ID: 36186623	2022
Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site. Research and practice in thrombosis and haemostasis\| PubMed ID: 36865905	2023