Sarah K. Wootton Department of Pathobiology University of Guelph Biography Publications Institution JoVE Articles Sarah K. Wootton has not added a biography. If you are Sarah K. Wootton and would like to personalize this page please email our Author Liaison for assistance. Publications Oncolytic Orf Virus Licenses NK Cells Via CDC1 to Activate Innate and Adaptive Antitumor Mechanisms and Extends Survival in a Murine Model of Late-stage Ovarian Cancer Journal for Immunotherapy of Cancer. Mar, 2022 | Pubmed ID: 35296558 AAV-Vectored Expression of the Vascular Normalizing Agents 3TSR and Fc3TSR, and the Anti-Angiogenic Bevacizumab Extends Survival in a Murine Model of End-Stage Epithelial Ovarian Carcinoma Biomedicines. Feb, 2022 | Pubmed ID: 35203573 Addition of an Fc-IgG Induces Receptor Clustering and Increases the in Vitro Efficacy and in Vivo Anti-tumor Properties of the Thrombospondin-1 Type I Repeats (3TSR) in a Mouse Model of Advanced Stage Ovarian Cancer Gynecologic Oncology. 01, 2022 | Pubmed ID: 34799137 Using a Prime-Boost Vaccination Strategy That Proved Effective for High Resolution Epitope Mapping to Characterize the Elusive Immunogenicity of Survivin Cancers. Dec, 2021 | Pubmed ID: 34944889 Process Development for Newcastle Disease Virus-Vectored Vaccines in Serum-Free Vero Cell Suspension Cultures Vaccines. Nov, 2021 | Pubmed ID: 34835266 Production and Purification of High-titer OrfV for Preclinical Studies in Vaccinology and Cancer Therapy Molecular Therapy. Methods & Clinical Development. Dec, 2021 | Pubmed ID: 34786436 Macrophage Depletion Via Clodronate Pretreatment Reduces Transgene Expression from AAV Vectors In Vivo Viruses. 10, 2021 | Pubmed ID: 34696433 Intranasal Vaccination with a Newcastle Disease Virus-vectored Vaccine Protects Hamsters from SARS-CoV-2 Infection and Disease IScience. Nov, 2021 | Pubmed ID: 34632328 Safety and Tolerability of the Adeno-Associated Virus Vector, AAV6.2FF, Expressing a Monoclonal Antibody in Murine and Ovine Animal Models Biomedicines. Sep, 2021 | Pubmed ID: 34572372 Gene Therapy for Fabry Disease: Progress, Challenges, and Outlooks on Gene-editing Molecular Genetics and Metabolism. Sep-Oct, 2021 | Pubmed ID: 34340879 Efficient Transduction of Alveolar Type 2 Cells with Adeno-associated Virus for the Study of Lung Regeneration American Journal of Respiratory Cell and Molecular Biology. 07, 2021 | Pubmed ID: 34241584 A Novel Mouse AAV6 HACE2 Transduction Model of Wild-type SARS-CoV-2 Infection Studied Using SynDNA Immunogens IScience. Jul, 2021 | Pubmed ID: 34124612 The Role of Type I Interferon Signaling in Regulating Cytokine Production and Cell Survival in Bone Marrow-Derived Macrophages Viral Immunology. Jun, 2021 | Pubmed ID: 34097550 Type I Interferon-Mediated Regulation of Antiviral Capabilities of Neutrophils International Journal of Molecular Sciences. Apr, 2021 | Pubmed ID: 33946935 Combining Vanadyl Sulfate with Newcastle Disease Virus Potentiates Rapid Innate Immune-mediated Regression with Curative Potential in Murine Cancer Models Molecular Therapy Oncolytics. Mar, 2021 | Pubmed ID: 33614913 AAV-mediated Delivery of Actoxumab and Bezlotoxumab Results in Serum and Mucosal Antibody Concentrations That Provide Protection from C. Difficile Toxin Challenge Gene Therapy. Feb, 2021 | Pubmed ID: 33608675 AAV Vectored Immunoprophylaxis for Filovirus Infections Tropical Medicine and Infectious Disease. Nov, 2020 | Pubmed ID: 33182447 JSRV Intragenic Enhancer Element Increases Expression from a Heterologous Promoter and Promotes High Level AAV-mediated Transgene Expression in the Lung and Liver of Mice Viruses. 11, 2020 | Pubmed ID: 33172105 Engineered AAV8 Capsid Acquires Heparin and AVB Sepharose Binding Capacity but Has Altered in Vivo Transduction Efficiency Gene Therapy. Oct, 2020 | Pubmed ID: 33028973 Tumour Vasculature: Friend or Foe of Oncolytic Viruses? Cytokine & Growth Factor Reviews. 12, 2020 | Pubmed ID: 32893095 Characterization of the Impact of Oncolytic Vesicular Stomatitis Virus on the Trafficking, Phenotype, and Antigen Presentation Potential of Neutrophils and Their Ability to Acquire a Non-Structural Viral Protein International Journal of Molecular Sciences. Sep, 2020 | Pubmed ID: 32882969 VHSV IVb Infection and Autophagy Modulation in the Rainbow Trout Gill Epithelial Cell Line RTgill-W1 Journal of Fish Diseases. Oct, 2020 | Pubmed ID: 32794227 A Lung Tropic AAV Vector Improves Survival in a Mouse Model of Surfactant B Deficiency Nature Communications. 08, 2020 | Pubmed ID: 32764559 Interference Chromatography: a Novel Approach to Optimizing Chromatographic Selectivity and Separation Performance for Virus Purification BMC Biotechnology. 06, 2020 | Pubmed ID: 32552807 Optimized Pre-Clinical Grade Production of Two Novel Lentiviral Vector Pseudotypes for Lung Gene Delivery Human Gene Therapy. 04, 2020 | Pubmed ID: 32000531 AAV-mediated Expression of 3TSR Inhibits Tumor and Metastatic Lesion Development and Extends Survival in a Murine Model of Epithelial Ovarian Carcinoma Cancer Gene Therapy. 05, 2020 | Pubmed ID: 31160686 The U3 and Env Proteins of Jaagsiekte Sheep Retrovirus and Enzootic Nasal Tumor Virus Both Contribute to Tissue Tropism Viruses. 11, 2019 | Pubmed ID: 31739606 Quantifying Antibody Responses Induced by Antigen-Agnostic Immunotherapies Molecular Therapy. Methods & Clinical Development. Sep, 2019 | Pubmed ID: 31388514 Myeloid Cells During Viral Infections and Inflammation Viruses. 02, 2019 | Pubmed ID: 30791481 Quantifying Antigen-Specific T Cell Responses When Using Antigen-Agnostic Immunotherapies Molecular Therapy. Methods & Clinical Development. Jun, 2019 | Pubmed ID: 30788384 AAV-Mediated Gene Delivery to the Lung Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30783985 Combining Vascular Normalization with an Oncolytic Virus Enhances Immunotherapy in a Preclinical Model of Advanced-Stage Ovarian Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 03, 2019 | Pubmed ID: 30206160 The Effects of in Ovo Administration of Encapsulated Toll-like Receptor 21 Ligand As an Adjuvant with Marek's Disease Vaccine Scientific Reports. 11, 2018 | Pubmed ID: 30401976 Use of Precision-Cut Lung Slices As an Tool for Evaluating Viruses and Viral Vectors for Gene and Oncolytic Therapy Molecular Therapy. Methods & Clinical Development. Sep, 2018 | Pubmed ID: 30112421 A Novel Triple-Mutant AAV6 Capsid Induces Rapid and Potent Transgene Expression in the Muscle and Respiratory Tract of Mice Molecular Therapy. Methods & Clinical Development. Jun, 2018 | Pubmed ID: 30038936 In Ovo Administration of Toll-like Receptor Ligands Encapsulated in PLGA Nanoparticles Impede Tumor Development in Chickens Infected with Marek's Disease Virus Vaccine. 06, 2018 | Pubmed ID: 29859800 Production and Purification of High-Titer Newcastle Disease Virus for Use in Preclinical Mouse Models of Cancer Molecular Therapy. Methods & Clinical Development. Jun, 2018 | Pubmed ID: 29556508 Intramuscular Adeno-Associated Virus-Mediated Expression of Monoclonal Antibodies Provides 100% Protection Against Ebola Virus Infection in Mice The Journal of Infectious Diseases. 03, 2018 | Pubmed ID: 29365142 Critical Interactions Between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies Journal of Immunology (Baltimore, Md. : 1950). 01, 2018 | Pubmed ID: 29311387 Enhancing Immune Responses to Cancer Vaccines Using Multi-Site Injections Scientific Reports. 08, 2017 | Pubmed ID: 28814733 AAV Vector Distribution in the Mouse Respiratory Tract Following Four Different Methods of Administration BMC Biotechnology. 05, 2017 | Pubmed ID: 28506256 Prevalence of Small Ruminant Lentivirus and Subsp. Co-infection in Ontario Dairy Sheep and Dairy Goats Canadian Journal of Veterinary Research = Revue Canadienne De Recherche Veterinaire. Apr, 2017 | Pubmed ID: 28408784 Truncation of the Enzootic Nasal Tumor Virus Envelope Protein Cytoplasmic Tail Increases Env-mediated Fusion and Infectivity The Journal of General Virology. 01, 2017 | Pubmed ID: 27902399 Construction of a Molecular Clone of Ovine Enzootic Nasal Tumor Virus Virology Journal. 12, 2016 | Pubmed ID: 28038674 Akt Isoform Specific Effects in Ovarian Cancer Progression Oncotarget. Nov, 2016 | Pubmed ID: 27533079 Seroconversion of Sheep Experimentally Infected with Enzootic Nasal Tumor Virus BMC Research Notes. Jan, 2016 | Pubmed ID: 26744306 Effects of Interferon-γ Knockdown on Vaccine-induced Immunity Against Marek's Disease in Chickens Canadian Journal of Veterinary Research = Revue Canadienne De Recherche Veterinaire. Jan, 2015 | Pubmed ID: 25673902 The Sheep Tetherin Paralog OBST2B Blocks Envelope Glycoprotein Incorporation into Nascent Retroviral Virions Journal of Virology. Jan, 2015 | Pubmed ID: 25339764 Immunogenetics of Small Ruminant Lentiviral Infections Viruses. Aug, 2014 | Pubmed ID: 25153344 Development of an Ante-mortem Diagnostic Test for Enzootic Nasal Tumor Virus and Detection of Neutralizing Antibodies in Host Serum The Journal of General Virology. Aug, 2014 | Pubmed ID: 24836673 Opposing Functions of Akt Isoforms in Lung Tumor Initiation and Progression PloS One. 2014 | Pubmed ID: 24722238 Jaagsiekte Sheep Retrovirus Detected in Human Lung Cancer Tissue Arrays BMC Research Notes. Mar, 2014 | Pubmed ID: 24642139 Experimental Transmission of Enzootic Nasal Adenocarcinoma in Sheep Veterinary Research. Jul, 2013 | Pubmed ID: 23899161 Genetic Characterization of Small Ruminant Lentiviruses Circulating in Naturally Infected Sheep and Goats in Ontario, Canada Virus Research. Jul, 2013 | Pubmed ID: 23583225 Small Interfering RNA-mediated Knockdown of Chicken Interferon-γ Expression Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Jun, 2013 | Pubmed ID: 23458611 Adeno-associated Virus Vector Mediated Expression of an Oncogenic Retroviral Envelope Protein Induces Lung Adenocarcinomas in Immunocompetent Mice PloS One. 2012 | Pubmed ID: 23251519 Jaagsiekte Sheep Retrovirus and Enzootic Nasal Tumor Virus Promoters Drive Gene Expression in All Airway Epithelial Cells of Mice but Only Induce Tumors in the Alveolar Region of the Lungs Journal of Virology. Aug, 2011 | Pubmed ID: 21593165 Full-length Genome Sequence Analysis of Enzootic Nasal Tumor Virus Reveals an Unusually High Degree of Genetic Stability Virus Research. Jul, 2010 | Pubmed ID: 20398709 Colocalization and Interaction of the Porcine Arterivirus Nucleocapsid Protein with the Small Nucleolar RNA-associated Protein Fibrillarin Journal of Virology. Nov, 2003 | Pubmed ID: 14581554 Homo-oligomerization of the Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Protein and the Role of Disulfide Linkages Journal of Virology. Apr, 2003 | Pubmed ID: 12663761 Phosphorylation of the Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Protein Journal of Virology. Oct, 2002 | Pubmed ID: 12239338 Antigenic Structure of the Nucleocapsid Protein of Porcine Reproductive and Respiratory Syndrome Virus Clinical and Diagnostic Laboratory Immunology. Nov, 1998 | Pubmed ID: 9801333 Производство высокотитерного рекомбинантного вируса болезни Ньюкасла из аллантойной жидкости Jacob G. E. Yates1, Alexander Leacy1, Phuc H. Pham1, Nicole Zielinska1, Emily A. Tusnadi1, Leonardo Susta1, Sarah K. Wootton1 1Department of Pathobiology, University of Guelph JoVE 63817 Cancer Research Производство аденоассоциированных вирусных векторов в клеточных стеках для доклинических исследований на крупных животных моделях Amira D. Rghei1, Brenna A. Y. Stevens*1, Sylvia P. Thomas*1, Jacob G. E. Yates*1, Benjamin M. McLeod1, Khalil Karimi1, Leonardo Susta1, Byram W. Bridle1, Sarah K. Wootton1 1Department of Pathobiology, University of Guelph JoVE 62727 Immunology and Infection
Производство высокотитерного рекомбинантного вируса болезни Ньюкасла из аллантойной жидкости Jacob G. E. Yates1, Alexander Leacy1, Phuc H. Pham1, Nicole Zielinska1, Emily A. Tusnadi1, Leonardo Susta1, Sarah K. Wootton1 1Department of Pathobiology, University of Guelph JoVE 63817 Cancer Research
Производство аденоассоциированных вирусных векторов в клеточных стеках для доклинических исследований на крупных животных моделях Amira D. Rghei1, Brenna A. Y. Stevens*1, Sylvia P. Thomas*1, Jacob G. E. Yates*1, Benjamin M. McLeod1, Khalil Karimi1, Leonardo Susta1, Byram W. Bridle1, Sarah K. Wootton1 1Department of Pathobiology, University of Guelph JoVE 62727 Immunology and Infection
