Stuart J. Forbes

Publications

• TFEB Regulates Murine Liver Cell Fate During Development and Regeneration
  Nature Communications. May, 2020  |   Pubmed ID: 32424153
• Absolute Measurement of the Tissue Origins of Cell-free DNA in the Healthy State and Following Paracetamol Overdose
  BMC Medical Genomics. Apr, 2020  |   Pubmed ID: 32252771
• Regional Differences in Human Biliary Tissues and Corresponding in Vitro Derived Organoids
  Hepatology (Baltimore, Md.). Mar, 2020  |   Pubmed ID: 32222998
• Expansion, in Vivo-ex Vivo Cycling, and Genetic Manipulation of Primary Human Hepatocytes
  Proceedings of the National Academy of Sciences of the United States of America. 01, 2020  |   Pubmed ID: 31915293
• Peribiliary Gland Niche Participates in Biliary Tree Regeneration in Mouse and in Human Primary Sclerosing Cholangitis
  Hepatology (Baltimore, Md.). Mar, 2020  |   Pubmed ID: 31330051
• Modulation of Biliary Cancer Chemo-resistance Through MicroRNA-mediated Rewiring of the Expansion of CD133+ Cells
  Hepatology (Baltimore, Md.). Dec, 2019  |   Pubmed ID: 31879968
• Epigenetic Remodelling Licences Adult Cholangiocytes for Organoid Formation and Liver Regeneration
  Nature Cell Biology. 11, 2019  |   Pubmed ID: 31685987
• Safety Profile of Autologous Macrophage Therapy for Liver Cirrhosis
  Nature Medicine. 10, 2019  |   Pubmed ID: 31591593
• Macrophages As a Cell-Based Therapy for Liver Disease
  Seminars in Liver Disease. 11, 2019  |   Pubmed ID: 31242527
• Beneficial Noncancerous Mutations in Liver Disease
  Trends in Genetics : TIG. 07, 2019  |   Pubmed ID: 31151757
• Quantifying Changes in Innate Immune Function Following Liver Transplantation for Chronic Liver Disease
  HPB : the Official Journal of the International Hepato Pancreato Biliary Association. 10, 2019  |   Pubmed ID: 30850189
• An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade
  Cancer Research. 04, 2019  |   Pubmed ID: 30674531
• Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice
  Stem Cells Translational Medicine. 03, 2019  |   Pubmed ID: 30394698
• Cellular Plasticity in Liver Regeneration: Spotlight on Cholangiocytes
  Hepatology (Baltimore, Md.). May, 2019  |   Pubmed ID: 30382597
• Hepatocyte-Specific β-Catenin Deletion During Severe Liver Injury Provokes Cholangiocytes to Differentiate Into Hepatocytes
  Hepatology (Baltimore, Md.). 02, 2019  |   Pubmed ID: 30215850
• Telomerase Activity Links to Regenerative Capacity of Hepatocytes
  Transplantation. 10, 2018  |   Pubmed ID: 30247437
• 3D Human Liver Tissue from Pluripotent Stem Cells Displays Stable Phenotype in Vitro and Supports Compromised Liver Function in Vivo
  Archives of Toxicology. 10, 2018  |   Pubmed ID: 30155720
• TGFβ Inhibition Restores a Regenerative Response in Acute Liver Injury by Suppressing Paracrine Senescence
  Science Translational Medicine. 08, 2018  |   Pubmed ID: 30111642
• Paracrine Cellular Senescence Exacerbates Biliary Injury and Impairs Regeneration
  Nature Communications. 03, 2018  |   Pubmed ID: 29523787
• Studies of Macrophage Therapy for Cirrhosis - From Mice to Men
  Journal of Hepatology. 05, 2018  |   Pubmed ID: 29317297
• GADD45β Loss Ablates Innate Immunosuppression in Cancer
  Cancer Research. 03, 2018  |   Pubmed ID: 29279355
• The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury
  Journal of Immunology (Baltimore, Md. : 1950). 02, 2018  |   Pubmed ID: 29263216
• 11Beta-hydroxysteroid Dehydrogenase-1 Deficiency or Inhibition Enhances Hepatic Myofibroblast Activation in Murine Liver Fibrosis
  Hepatology (Baltimore, Md.). 06, 2018  |   Pubmed ID: 29251794
• Raman Spectroscopy and Regenerative Medicine: a Review
  NPJ Regenerative Medicine. 2017  |   Pubmed ID: 29302348
• Cholangiocytes Act As Facultative Liver Stem Cells During Impaired Hepatocyte Regeneration
  Nature. 07, 2017  |   Pubmed ID: 28700576
• Development, Functional Characterization and Validation of Methodology for GMP-compliant Manufacture of Phagocytic Macrophages: A Novel Cellular Therapeutic for Liver Cirrhosis
  Cytotherapy. 09, 2017  |   Pubmed ID: 28673774
• Milk Fat Globule-EGF Factor 8 for Liver Fibrosis Therapy: Creaming Off the Beneficial Effects of Mesenchymal Stromal Cells
  Gastroenterology. 04, 2017  |   Pubmed ID: 28259796
• Functionalized Superparamagnetic Iron Oxide Nanoparticles Provide Highly Efficient Iron-labeling in Macrophages for Magnetic Resonance-based Detection in Vivo
  Cytotherapy. 04, 2017  |   Pubmed ID: 28214127
• Wnt Signalling Modulates Transcribed-ultraconserved Regions in Hepatobiliary Cancers
  Gut. 07, 2017  |   Pubmed ID: 27618837
• Advances in Cholangiocarcinoma Research: Report from the Third Cholangiocarcinoma Foundation Annual Conference
  Journal of Gastrointestinal Oncology. Dec, 2016  |   Pubmed ID: 28078106
• Notch3 Drives Development and Progression of Cholangiocarcinoma
  Proceedings of the National Academy of Sciences of the United States of America. 10, 2016  |   Pubmed ID: 27791012
• Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis
  Immunity. 07, 2016  |   Pubmed ID: 27421703
• Liver Regeneration - Mechanisms and Models to Clinical Application
  Nature Reviews. Gastroenterology & Hepatology. 08, 2016  |   Pubmed ID: 27353402
• Corrigendum to "Alternatively Activated (M2) Macrophages Promote Tumour Growth and Invasiveness in Hepatocellular Carcinoma" [J Hepatol 2015;62:607-616]
  Journal of Hepatology. Jun, 2016  |   Pubmed ID: 27198050
• Expert Consensus Document: Cholangiocarcinoma: Current Knowledge and Future Perspectives Consensus Statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
  Nature Reviews. Gastroenterology & Hepatology. 05, 2016  |   Pubmed ID: 27095655
• The RSPO-LGR4/5-ZNRF3/RNF43 Module Controls Liver Zonation and Size
  Nature Cell Biology. 05, 2016  |   Pubmed ID: 27088858
• Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs
  Stem Cells Translational Medicine. Jun, 2016  |   Pubmed ID: 27057006
• Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells
  Journal of the American Society of Nephrology : JASN. Nov, 2016  |   Pubmed ID: 27020854
• Recombinant Laminins Drive the Differentiation and Self-Organization of HESC-Derived Hepatocytes
  Stem Cell Reports. Dec, 2015  |   Pubmed ID: 26626180
• Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells Following Expansion in Long Term Adherent Culture
  PloS One. 2015  |   Pubmed ID: 26457418
• Two Fresh Streams to Fill the Liver's Hepatocyte Pool
  Cell Stem Cell. Oct, 2015  |   Pubmed ID: 26431179
• CSF1 Restores Innate Immunity After Liver Injury in Mice And Serum Levels Indicate Outcomes of Patients With Acute Liver Failure
  Gastroenterology. Dec, 2015  |   Pubmed ID: 26344055
• Phenotypic and Functional Characterization of Macrophages with Therapeutic Potential Generated from Human Cirrhotic Monocytes in a Cohort Study
  Cytotherapy. Nov, 2015  |   Pubmed ID: 26342993
• Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015)
  Advanced Healthcare Materials. Aug, 2015  |   Pubmed ID: 26308957
• Hepatic Progenitor Cells of Biliary Origin with Liver Repopulation Capacity
  Nature Cell Biology. Aug, 2015  |   Pubmed ID: 26192438
• Organoid Cultures Boost Human Liver Cell Expansion
  Hepatology (Baltimore, Md.). Nov, 2015  |   Pubmed ID: 26146934
• Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance
  Advanced Healthcare Materials. Aug, 2015  |   Pubmed ID: 26109270
• Alternatively Activated (M2) Macrophages Promote Tumour Growth and Invasiveness in Hepatocellular Carcinoma
  Journal of Hepatology. Mar, 2015  |   Pubmed ID: 25450711
• Preparing the Ground for Tissue Regeneration: from Mechanism to Therapy
  Nature Medicine. Aug, 2014  |   Pubmed ID: 25100531
• Galectin-3 Regulates Hepatic Progenitor Cell Expansion During Liver Injury
  Gut. May, 2014  |   Pubmed ID: 24837171
• Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome
  Case Reports in Transplantation. 2014  |   Pubmed ID: 24600525
• Polysialic Acid/neural Cell Adhesion Molecule Modulates the Formation of Ductular Reactions in Liver Injury
  Hepatology (Baltimore, Md.). Nov, 2014  |   Pubmed ID: 24585441
• Proteinase Activated Receptor 1 Mediated Fibrosis in a Mouse Model of Liver Injury: a Role for Bone Marrow Derived Macrophages
  PloS One. 2014  |   Pubmed ID: 24475094
• CD133+ Cancer Stem-like Cells in Small Cell Lung Cancer Are Highly Tumorigenic and Chemoresistant but Sensitive to a Novel Neuropeptide Antagonist
  Cancer Research. Mar, 2014  |   Pubmed ID: 24436149
• Links Between Hepatic Fibrosis, Ductular Reaction, and Progenitor Cell Expansion
  Gastroenterology. Feb, 2014  |   Pubmed ID: 24315991
• Cell Lineage Tracing Reveals a Biliary Origin of Intrahepatic Cholangiocarcinoma
  Cancer Research. Feb, 2014  |   Pubmed ID: 24310400
• Relaxin Modulates Human and Rat Hepatic Myofibroblast Function and Ameliorates Portal Hypertension in Vivo
  Hepatology (Baltimore, Md.). Apr, 2014  |   Pubmed ID: 23873655
• Differentiation of Progenitors in the Liver: a Matter of Local Choice
  The Journal of Clinical Investigation. May, 2013  |   Pubmed ID: 23635784
• Suppression of Epithelial to Mesenchymal Transitioning (EMT) Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue Towards Functional Insulin Producing β-Like Cells
  Diabetes. Apr, 2013  |   Pubmed ID: 23610058
• Bone Marrow Injection Stimulates Hepatic Ductular Reactions in the Absence of Injury Via Macrophage-mediated TWEAK Signaling
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013  |   Pubmed ID: 23576749
• Liver Sinusoidal Endothelial Cells in Disease--and for Therapy?
  Journal of Hepatology. Jan, 2013  |   Pubmed ID: 22892397
• Differential Ly-6C Expression Identifies the Recruited Macrophage Phenotype, Which Orchestrates the Regression of Murine Liver Fibrosis
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012  |   Pubmed ID: 23100531
• Macrophage-derived Wnt Opposes Notch Signaling to Specify Hepatic Progenitor Cell Fate in Chronic Liver Disease
  Nature Medicine. Apr, 2012  |   Pubmed ID: 22388089
• Elastin Accumulation is Regulated at the Level of Degradation by Macrophage Metalloelastase (MMP-12) During Experimental Liver Fibrosis
  Hepatology (Baltimore, Md.). Jun, 2012  |   Pubmed ID: 22223197
• Regulation of Transforming Growth Factor-β1-driven Lung Fibrosis by Galectin-3
  American Journal of Respiratory and Critical Care Medicine. Mar, 2012  |   Pubmed ID: 22095546
• Ly6Chi Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis
  American Journal of Respiratory and Critical Care Medicine. Sep, 2011  |   Pubmed ID: 21680953
• Liver Fibrogenic Cells
  Best Practice & Research. Clinical Gastroenterology. Apr, 2011  |   Pubmed ID: 21497739
• Matrix Stiffness Modulates Proliferation, Chemotherapeutic Response, and Dormancy in Hepatocellular Carcinoma Cells
  Hepatology (Baltimore, Md.). Apr, 2011  |   Pubmed ID: 21442631
• Macrophage Therapy for Murine Liver Fibrosis Recruits Host Effector Cells Improving Fibrosis, Regeneration, and Function
  Hepatology (Baltimore, Md.). Jun, 2011  |   Pubmed ID: 21433043
• Unbiased Screening of Polymer Libraries to Define Novel Substrates for Functional Hepatocytes with Inducible Drug Metabolism
  Stem Cell Research. Mar, 2011  |   Pubmed ID: 21277274
• Persistence of Functional Hepatocyte-like Cells in Immune-compromised Mice
  Liver International : Official Journal of the International Association for the Study of the Liver. Feb, 2011  |   Pubmed ID: 21143581
• Prospects for Stem Cell Transplantation in the Treatment of Hepatic Disease
  Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. Jul, 2010  |   Pubmed ID: 20583084
• Characterisation of a Stereotypical Cellular and Extracellular Adult Liver Progenitor Cell Niche in Rodents and Diseased Human Liver
  Gut. May, 2010  |   Pubmed ID: 20427399
• Portal Venous Endothelium in Developing Human Liver Contains Haematopoietic and Epithelial Progenitor Cells
  Experimental Cell Research. May, 2010  |   Pubmed ID: 20211168
• Liver Development, Regeneration, and Carcinogenesis
  Journal of Biomedicine & Biotechnology. 2010  |   Pubmed ID: 20169172
• Practical Barriers to Delivering Autologous Bone Marrow Stem Cell Therapy As an Adjunct to Liver Resection
  Stem Cells and Development. Feb, 2010  |   Pubmed ID: 19954303
• Generation of Functional Human Hepatic Endoderm from Human Induced Pluripotent Stem Cells
  Hepatology (Baltimore, Md.). Jan, 2010  |   Pubmed ID: 19877180
• A Fat Chance for Hepatocyte Transplantation?
  Gut. Apr, 2009  |   Pubmed ID: 19299381
• Side Population Cells in Developing Human Liver Are Primarily Haematopoietic Progenitor Cells
  Experimental Cell Research. Aug, 2009  |   Pubmed ID: 19233167
• The Isolation and in Vitro Expansion of Hepatic Sca-1 Progenitor Cells
  Biochemical and Biophysical Research Communications. Apr, 2009  |   Pubmed ID: 19233130
• Highly Efficient Differentiation of HESCs to Functional Hepatic Endoderm Requires ActivinA and Wnt3a Signaling
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008  |   Pubmed ID: 18719101
• The Inhibitory Role of Stromal Cell Mesenchyme on Human Embryonic Stem Cell Hepatocyte Differentiation is Overcome by Wnt3a Treatment
  Cloning and Stem Cells. Sep, 2008  |   Pubmed ID: 18479212
• Regulation of Alternative Macrophage Activation by Galectin-3
  Journal of Immunology (Baltimore, Md. : 1950). Feb, 2008  |   Pubmed ID: 18250477
• Stem Cell Therapy for Chronic Liver Disease--choosing the Right Tools for the Job
  Gut. Feb, 2008  |   Pubmed ID: 18192451
• Progenitor Cell Characterization and Location in the Developing Human Liver
  Stem Cells and Development. Oct, 2007  |   Pubmed ID: 17999598
• Selective Depletion of Macrophages Reveals Distinct, Opposing Roles During Liver Injury and Repair
  The Journal of Clinical Investigation. Jan, 2005  |   Pubmed ID: 15630444