Sunil R. Lakhani UQ Centre for Clinical Research The University of Queensland Biography Publications Institution JoVE Articles Sunil R. Lakhani has not added a biography. If you are Sunil R. Lakhani and would like to personalize this page please email our Author Liaison for assistance. Publications The Increasing Importance of Pathology in Modern Clinical Trial Conduct: OlympiA As a Case in Point Pathology. Jun, 2022 | Pubmed ID: 35778289 Epigenome Erosion and SOX10 Drive Neural Crest Phenotypic Mimicry in Triple-negative Breast Cancer NPJ Breast Cancer. May, 2022 | Pubmed ID: 35501337 N-glycolylneuraminic Acid Serum Biomarker Levels Are Elevated in Breast Cancer Patients at All Stages of Disease BMC Cancer. Mar, 2022 | Pubmed ID: 35346112 Emerging Biomarkers for Diagnosis, Prevention and Treatment of Brain Metastases-From Biology to Clinical Utility Diseases (Basel, Switzerland). Feb, 2022 | Pubmed ID: 35225863 Landscape of Epidermal Growth Factor Receptor Heterodimers in Brain Metastases Cancers. Jan, 2022 | Pubmed ID: 35158800 Whole Genome Deep Sequencing Analysis of Cell-free DNA in Samples with Low Tumour Content BMC Cancer. Jan, 2022 | Pubmed ID: 35057759 Blood-Derived Extracellular Vesicle-Associated MiR-3182 Detects Non-Small Cell Lung Cancer Patients Cancers. Jan, 2022 | Pubmed ID: 35008424 Elevating CDCA3 Levels Enhances Tyrosine Kinase Inhibitor Sensitivity in TKI-Resistant EGFR Mutant Non-Small-Cell Lung Cancer Cancers. Sep, 2021 | Pubmed ID: 34572879 Correction: McCart Reed Et Al. The Genomic Landscape of Lobular Breast Cancer. 2021, , 1950 Cancers. Aug, 2021 | Pubmed ID: 34439402 Altered Calcium Influx Pathways in Cancer-Associated Fibroblasts Biomedicines. Jun, 2021 | Pubmed ID: 34208665 Characterization of Immune Cell Subsets of Tumor Infiltrating Lymphocytes in Brain Metastases Biology. 05, 2021 | Pubmed ID: 34064871 The Genomic Landscape of Lobular Breast Cancer Cancers. Apr, 2021 | Pubmed ID: 33919581 Tumor Signature Analysis Implicates Hereditary Cancer Genes in Endometrial Cancer Development Cancers. 04, 2021 | Pubmed ID: 33917078 Spatial Profiling Technologies and Applications for Brain Cancers Expert Review of Molecular Diagnostics. Mar, 2021 | Pubmed ID: 33685321 An Update on the Molecular Pathology of Metaplastic Breast Cancer Breast Cancer (Dove Medical Press). 2021 | Pubmed ID: 33664587 Invasive Lobular Carcinoma of the Breast: the Increasing Importance of This Special Subtype Breast Cancer Research : BCR. 01, 2021 | Pubmed ID: 33413533 Lobular Carcinoma in Situ: Diagnostic Criteria and Molecular Correlates Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. 01, 2021 | Pubmed ID: 33024303 The Mutational Landscape of Melanoma Brain Metastases Presenting As the First Visceral Site of Recurrence British Journal of Cancer. 01, 2021 | Pubmed ID: 33024263 Phenotypic Drift in Metastatic Progression of Breast Cancer: A Case Report with Histologically Heterogeneous Lesions That Are Clonally Related Clinical Case Reports. Dec, 2020 | Pubmed ID: 33363813 Clinicopathologic Significance of Nuclear HER4 and Phospho-YAP(S) in Human Breast Cancers and Matching Brain Metastases Therapeutic Advances in Medical Oncology. 2020 | Pubmed ID: 33014146 Metaplastic Breast Cancers Frequently Express Immune Checkpoint Markers FOXP3 and PD-L1 British Journal of Cancer. 11, 2020 | Pubmed ID: 32939056 Using Whole-genome Sequencing Data to Derive the Homologous Recombination Deficiency Scores NPJ Breast Cancer. 2020 | Pubmed ID: 32818150 Id Proteins Promote a Cancer Stem Cell Phenotype in Mouse Models of Triple Negative Breast Cancer Via Negative Regulation of Robo1 Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 32766238 Association of Sperm-Associated Antigen 5 and Treatment Response in Patients With Estrogen Receptor-Positive Breast Cancer JAMA Network Open. 07, 2020 | Pubmed ID: 32633764 Tradeoff Between Metabolic I-proteasome Addiction and Immune Evasion in Triple-negative Breast Cancer Life Science Alliance. 07, 2020 | Pubmed ID: 32423906 Morphologic and Genomic Heterogeneity in the Evolution and Progression of Breast Cancer Cancers. Mar, 2020 | Pubmed ID: 32244556 The Path to a Better Biomarker: Application of a Risk Management Framework for the Implementation of PD-L1 and TILs As Immuno-oncology Biomarkers in Breast Cancer Clinical Trials and Daily Practice The Journal of Pathology. 04, 2020 | Pubmed ID: 32129476 Non-coding RNAs Underlie Genetic Predisposition to Breast Cancer Genome Biology. 01, 2020 | Pubmed ID: 31910864 Breast Cancer Heterogeneity in Primary and Metastatic Disease Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 31456181 LobSig is a Multigene Predictor of Outcome in Invasive Lobular Carcinoma NPJ Breast Cancer. 2019 | Pubmed ID: 31263747 A Molecular and Morphological Deep-Dive Into Metaplastic Breast Cancers Cancer Informatics. 2019 | Pubmed ID: 31205411 Proteomic Analysis of the Breast Cancer Brain Metastasis Microenvironment International Journal of Molecular Sciences. May, 2019 | Pubmed ID: 31121957 Innovative Therapeutic Strategies for Effective Treatment of Brain Metastases International Journal of Molecular Sciences. Mar, 2019 | Pubmed ID: 30875730 Secreted Cellular Prion Protein Binds Doxorubicin and Correlates with Anthracycline Resistance in Breast Cancer JCI Insight. 02, 2019 | Pubmed ID: 30830863 Diff-Quik Cytology Smears from Endobronchial Ultrasound Transbronchial Needle Aspiration Lymph Node Specimens As a Source of DNA for Next-Generation Sequencing Instead of Cell Blocks Respiration; International Review of Thoracic Diseases. 2019 | Pubmed ID: 30731462 The Circular RNome of Primary Breast Cancer Genome Research. 03, 2019 | Pubmed ID: 30692147 Author Correction: Landscape of Somatic Mutations in 560 Breast Cancer Whole-genome Sequences Nature. 02, 2019 | Pubmed ID: 30659290 Recent Advances in Breast Cancer Research Impacting Clinical Diagnostic Practice The Journal of Pathology. 04, 2019 | Pubmed ID: 30426489 Phenotypic and Molecular Dissection of Metaplastic Breast Cancer and the Prognostic Implications The Journal of Pathology. 02, 2019 | Pubmed ID: 30350370 Breast Cancer Metastasis to Gynaecological Organs: a Clinico-pathological and Molecular Profiling Study The Journal of Pathology. Clinical Research. 01, 2019 | Pubmed ID: 30246500 CEP55 is a Determinant of Cell Fate During Perturbed Mitosis in Breast Cancer EMBO Molecular Medicine. 09, 2018 | Pubmed ID: 30108112 Characterization of a Novel Breast Cancer Cell Line Derived from a Metastatic Bone Lesion of a Breast Cancer Patient Breast Cancer Research and Treatment. Jul, 2018 | Pubmed ID: 29468485 Expression of MAGE-A and NY-ESO-1 Cancer/testis Antigens is Enriched in Triple-negative Invasive Breast Cancers Histopathology. Jul, 2018 | Pubmed ID: 29465777 Mixed Ductal-lobular Carcinomas: Evidence for Progression from Ductal to Lobular Morphology The Journal of Pathology. 04, 2018 | Pubmed ID: 29344954 Multidimensional Phenotyping of Breast Cancer Cell Lines to Guide Preclinical Research Breast Cancer Research and Treatment. 01, 2018 | Pubmed ID: 28889351 Association Analysis Identifies 65 New Breast Cancer Risk Loci Nature. Nov, 2017 | Pubmed ID: 29059683 Relationship of the Breast Ductal Carcinoma Immune Microenvironment with Clinicopathological and Genetic Features Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2017 | Pubmed ID: 28611201 Breast Ductal Carcinoma in Situ Carry Mutational Driver Events Representative of Invasive Breast Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. 07, 2017 | Pubmed ID: 28338653 HRDetect is a Predictor of BRCA1 and BRCA2 Deficiency Based on Mutational Signatures Nature Medicine. Apr, 2017 | Pubmed ID: 28288110 A Somatic-mutational Process Recurrently Duplicates Germline Susceptibility Loci and Tissue-specific Super-enhancers in Breast Cancers Nature Genetics. Mar, 2017 | Pubmed ID: 28112740 Breast Cancer Brain Metastases: Clonal Evolution in Clinical Context International Journal of Molecular Sciences. Jan, 2017 | Pubmed ID: 28098771 Environmental Factors in Breast Cancer Invasion: a Mathematical Modelling Review Pathology. Feb, 2017 | Pubmed ID: 28081961 Current Topics in Breast Pathology: Expert Perspectives Pathology. Feb, 2017 | Pubmed ID: 28069256 'Omics Approaches in Breast Cancer Research and Clinical Practice Advances in Anatomic Pathology. Nov, 2016 | Pubmed ID: 27740960 Breast Cancer Genome and Transcriptome Integration Implicates Specific Mutational Signatures with Immune Cell Infiltration Nature Communications. Sep, 2016 | Pubmed ID: 27666519 SASH1 Mediates Sensitivity of Breast Cancer Cells to Chloropyramine and is Associated with Prognosis in Breast Cancer Oncotarget. 11, 2016 | Pubmed ID: 27637080 Long-range Regulators of the LncRNA HOTAIR Enhance Its Prognostic Potential in Breast Cancer Human Molecular Genetics. 08, 2016 | Pubmed ID: 27378691 Standardized Evaluation of Tumor-infiltrating Lymphocytes in Breast Cancer: Results of the Ring Studies of the International Immuno-oncology Biomarker Working Group Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. 10, 2016 | Pubmed ID: 27363491 The Calcium Pump Plasma Membrane Ca(2+)-ATPase 2 (PMCA2) Regulates Breast Cancer Cell Proliferation and Sensitivity to Doxorubicin Scientific Reports. 05, 2016 | Pubmed ID: 27148852 Landscape of Somatic Mutations in 560 Breast Cancer Whole-genome Sequences Nature. 06, 2016 | Pubmed ID: 27135926 Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach As a Familial Adenomatous Polyposis Variant American Journal of Human Genetics. 05, 2016 | Pubmed ID: 27087319 High Content Screening Application for Cell-type Specific Behaviour in Heterogeneous Primary Breast Epithelial Subpopulations Breast Cancer Research : BCR. Feb, 2016 | Pubmed ID: 26861772 Novel Highly Specific Anti-periostin Antibodies Uncover the Functional Importance of the Fascilin 1-1 Domain and Highlight Preferential Expression of Periostin in Aggressive Breast Cancer International Journal of Cancer. Apr, 2016 | Pubmed ID: 26619948 An Epithelial to Mesenchymal Transition Programme Does Not Usually Drive the Phenotype of Invasive Lobular Carcinomas The Journal of Pathology. Mar, 2016 | Pubmed ID: 26510554 TGFβ Isoforms and Receptors MRNA Expression in Breast Tumours: Prognostic Value and Clinical Implications BMC Cancer. Dec, 2015 | Pubmed ID: 26703884 Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib PloS One. 2015 | Pubmed ID: 25969993 Invasive Lobular Carcinoma of the Breast: Morphology, Biomarkers and 'omics Breast Cancer Research : BCR. Jan, 2015 | Pubmed ID: 25849106 ID4 Controls Mammary Stem Cells and Marks Breast Cancers with a Stem Cell-like Phenotype Nature Communications. Mar, 2015 | Pubmed ID: 25813983 Heregulin-HER3-HER2 Signaling Promotes Matrix Metalloproteinase-dependent Blood-brain-barrier Transendothelial Migration of Human Breast Cancer Cell Lines Oncotarget. Feb, 2015 | Pubmed ID: 25668816 Molecular Classification of Breast Cancer Virchows Archiv : an International Journal of Pathology. Jul, 2014 | Pubmed ID: 24878755 Multifactorial Likelihood Assessment of BRCA1 and BRCA2 Missense Variants Confirms That BRCA1:c.122A>G(p.His41Arg) is a Pathogenic Mutation PloS One. 2014 | Pubmed ID: 24489791 Is the One-step Nucleic Acid Amplification Assay Better for Intra-operative Assessment of Breast Sentinel Nodes? ANZ Journal of Surgery. Oct, 2014 | Pubmed ID: 24397867 Metastatic Progression of Breast Cancer: Insights from 50 Years of Autopsies The Journal of Pathology. Jan, 2014 | Pubmed ID: 24122263 Signatures of Mutational Processes in Human Cancer Nature. Aug, 2013 | Pubmed ID: 23945592 In Vitro Analysis of Breast Cancer Cell Line Tumourspheres and Primary Human Breast Epithelia Mammospheres Demonstrates Inter- and Intrasphere Heterogeneity PloS One. 2013 | Pubmed ID: 23750209 Multiple Independent Variants at the TERT Locus Are Associated with Telomere Length and Risks of Breast and Ovarian Cancer Nature Genetics. Apr, 2013 | Pubmed ID: 23535731 MicroRNA-182-5p Targets a Network of Genes Involved in DNA Repair RNA (New York, N.Y.). Feb, 2013 | Pubmed ID: 23249749 Expression Profiling of Archival Tumors for Long-term Health Studies Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2012 | Pubmed ID: 23136189 Expression and Function of the Protein Tyrosine Phosphatase Receptor J (PTPRJ) in Normal Mammary Epithelial Cells and Breast Tumors PloS One. 2012 | Pubmed ID: 22815804 Calcium Channel TRPV6 As a Potential Therapeutic Target in Estrogen Receptor-negative Breast Cancer Molecular Cancer Therapeutics. Oct, 2012 | Pubmed ID: 22807578 Gene Expression Profiling of Tumour Epithelial and Stromal Compartments During Breast Cancer Progression Breast Cancer Research and Treatment. Aug, 2012 | Pubmed ID: 22718308 Molecular Aspects of Breast Cancer Metastasis to the Brain Genetics Research International. 2011 | Pubmed ID: 22567347 Tumor Heterogeneity in a Follicular Carcinoma of Thyroid: a Study by Comparative Genomic Hybridization Endocrine Pathology. Jun, 2011 | Pubmed ID: 21499728 Phenotype-genotype Correlation in Familial Breast Cancer Journal of Mammary Gland Biology and Neoplasia. Apr, 2011 | Pubmed ID: 21400086 Molecular Classification of Breast Cancer: is It Time to Pack Up Our Microscopes? Pathology. Jan, 2011 | Pubmed ID: 21240058 Application of Molecular Findings to the Diagnosis and Management of Breast Disease: Recent Advances and Challenges Human Pathology. Feb, 2011 | Pubmed ID: 21106225 HER3 and Downstream Pathways Are Involved in Colonization of Brain Metastases from Breast Cancer Breast Cancer Research : BCR. 2010 | Pubmed ID: 20604919 The Contribution of Breast Cancer Pathology to Statistical Models to Predict Mutation Risk in BRCA Carriers Familial Cancer. Dec, 2010 | Pubmed ID: 20577821 Pathology of Hereditary Breast Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. May, 2010 | Pubmed ID: 20436502 Pleomorphic Lobular Carcinoma of the Breast: Molecular Pathology and Clinical Impact Future Oncology (London, England). Mar, 2009 | Pubmed ID: 19284381 Current and Future Approach to the Pathologist's Assessment for Targeted Therapy in Breast Cancer Pathology. Jan, 2009 | Pubmed ID: 19089744 Basal-like Grade III Invasive Ductal Carcinoma of the Breast: Patterns of Metastasis and Long-term Survival Breast Cancer Research : BCR. 2007 | Pubmed ID: 17217540 The Management of Lobular Carcinoma in Situ (LCIS). Is LCIS the Same As Ductal Carcinoma in Situ (DCIS)? European Journal of Cancer (Oxford, England : 1990). Sep, 2006 | Pubmed ID: 16876991 Prediction of BRCA1 Status in Patients with Breast Cancer Using Estrogen Receptor and Basal Phenotype Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2005 | Pubmed ID: 16033833 Modellering av hjernemetastase ved intern karotisarterieinjeksjon av kreftceller Malcolm Lim1, Nicholas Fletcher2, Amy McCart Reed1, Melanie Flint3, Kristofer Thurecht2, Jodi Saunus*1,4, Sunil R. Lakhani*1,5 1UQ Centre for Clinical Research, The University of Queensland, 2Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology and ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, 3School of Biomedical Sciences, The University of Queensland, 4Mater Research and Mater Research Institute, The University of Queensland, 5Pathology Queensland, Royal Brisbane Women's Hospital JoVE 64216 Cancer Research
Modellering av hjernemetastase ved intern karotisarterieinjeksjon av kreftceller Malcolm Lim1, Nicholas Fletcher2, Amy McCart Reed1, Melanie Flint3, Kristofer Thurecht2, Jodi Saunus*1,4, Sunil R. Lakhani*1,5 1UQ Centre for Clinical Research, The University of Queensland, 2Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology and ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, 3School of Biomedical Sciences, The University of Queensland, 4Mater Research and Mater Research Institute, The University of Queensland, 5Pathology Queensland, Royal Brisbane Women's Hospital JoVE 64216 Cancer Research