Takeo Nakanishi

Membrane Transport and Biopharmaceutics, Kanazawa University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2016

Other Publications

Article	Year
Transport of D-serine via the amino acid transporter ATB(0,+) expressed in the colon. Biochemical and biophysical research communications\| PubMed ID: 11846403	2002
Timed sequential therapy of acute leukemia with flavopiridol: in vitro model for a phase I clinical trial. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 12538483	2003
Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 12960118	2003
Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of Xenopus laevis. Molecular pharmacology\| PubMed ID: 14645676	2003
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. The Journal of biological chemistry\| PubMed ID: 15044468	2004
Breast cancer resistance protein (BCRP/MXR/ABCG2) in adult acute lymphoblastic leukaemia: frequent expression and possible correlation with shorter disease-free survival. British journal of haematology\| PubMed ID: 15521915	2004
Evaluation of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes. Drug metabolism and pharmacokinetics\| PubMed ID: 15618650	2002
Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations. Molecular pharmaceutics\| PubMed ID: 15832501	2004
The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15994225	2005
Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression. Blood\| PubMed ID: 16543472	2006
Novel 5' untranslated region variants of BCRP mRNA are differentially expressed in drug-selected cancer cells and in normal human tissues: implications for drug resistance, tissue-specific e... Cancer research\| PubMed ID: 16707421	2006
Thapsigargin resistance in human prostate cancer cells. Cancer\| PubMed ID: 16770788	2006
Alterations in the mitochondrial proteome of adriamycin resistant MCF-7 breast cancer cells. Journal of proteome research\| PubMed ID: 16944951	2006
Drug transporters as targets for cancer chemotherapy. Cancer genomics & proteomics\| PubMed ID: 17878527	2007
The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells. The Journal of biological chemistry\| PubMed ID: 18056989	2008
Preclinical studies of vorinostat (suberoylanilide hydroxamic acid) combined with cytosine arabinoside and etoposide for treatment of acute leukemias. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19223502	2009
Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells. Biopharmaceutics & drug disposition\| PubMed ID: 19322909	2009
Organic anion transporter OAT1 is involved in renal handling of citrulline. American journal of physiology. Renal physiology\| PubMed ID: 19403644	2009
Hepatic uptake of gamma-butyrobetaine, a precursor of carnitine biosynthesis, in rats. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 19679820	2009
Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 19779132	2010
Impact of breast cancer resistance protein on cancer treatment outcomes. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19949928	2010
Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carri... Molecular pharmaceutics\| PubMed ID: 20020740	2010
Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human. Biological & pharmaceutical bulletin\| PubMed ID: 20190416	2010
Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake. Biological & pharmaceutical bulletin\| PubMed ID: 20410607	2010
Methods to evaluate transporter activity in cancer. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20419431	2010
Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors... Biochemical pharmacology\| PubMed ID: 20510678	2010
Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer. The Journal of steroid biochemistry and molecular biology\| PubMed ID: 20615467	2010
Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide. Pharmaceutical research\| PubMed ID: 20686826	2010
A novel xenobiotic responsive element regulated by aryl hydrocarbon receptor is involved in the induction of BCRP/ABCG2 in LS174T cells. Biochemical pharmacology\| PubMed ID: 20804740	2010
Organic cation transporter-mediated renal secretion of ipratropium and tiotropium in rats and humans. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 20962061	2011
Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats. Biochimica et biophysica acta\| PubMed ID: 21074513	2011
Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1. Drug metabolism and pharmacokinetics\| PubMed ID: 21206133	2011
Drug efflux by breast cancer resistance protein is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924. Molecular cancer therapeutics\| PubMed ID: 21220496	2011
Total syntheses of (-)- and (+)-goniomitine. Organic letters\| PubMed ID: 21375315	2011
Quantitative time-lapse imaging-based analysis of drug-drug interaction mediated by hepatobiliary transporter, multidrug resistance-associated protein 2, in sandwich-cultured rat hepatocytes... Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 21415249	2011
Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein. Journal of pharmaceutical sciences\| PubMed ID: 21520088	2011
Putative transport mechanism and intracellular fate of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in human prostate cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 21536930	2011
Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 21606177	2011
Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy. Journal of pharmaceutical sciences\| PubMed ID: 21630275	2011
Identification and characterization of the major alternative promoter regulating Bcrp1/Abcg2 expression in the mouse intestine. Biochimica et biophysica acta\| PubMed ID: 21718815	2011
Carnitine precursor γ-butyrobetaine is a novel substrate of the Na(+)- and Cl(-)-dependent GABA transporter Gat2. Drug metabolism and pharmacokinetics\| PubMed ID: 21997971	2011
Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture. Molecular pharmaceutics\| PubMed ID: 21999946	2011
Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression. Chinese journal of cancer\| PubMed ID: 22098950	2012
Effect of back pressure on emulsification of lipid nanodispersions in a high-pressure homogenizer. International journal of pharmaceutics\| PubMed ID: 22108638	2012
Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs. Drug metabolism and pharmacokinetics\| PubMed ID: 22185815	2012
Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites. Drug metabolism and pharmacokinetics\| PubMed ID: 22201122	2012
Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: formation of ... Xenobiotica; the fate of foreign compounds in biological systems\| PubMed ID: 22324379	2012
Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2. PloS one\| PubMed ID: 22348008	2012
Application of quantitative time-lapse imaging (QTLI) for evaluation of Mrp2-based drug-drug interaction induced by liver metabolites. Toxicology and applied pharmacology\| PubMed ID: 22766462	2012
Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-de... Biochemical pharmacology\| PubMed ID: 22864060	2012
Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5. Biopharmaceutics & drug disposition\| PubMed ID: 22899169	2012
Functional cooperation of SMCTs and URAT1 for renal reabsorption transport of urate. Drug metabolism and pharmacokinetics\| PubMed ID: 22971602	2013
Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions. Journal of pharmaceutical sciences\| PubMed ID: 23132664	2013
Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 23264447	2013
Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 23291366	2013
A role of prostaglandin transporter in regulating PGE₂ release from human bronchial epithelial BEAS-2B cells in response to LPS. The Journal of endocrinology\| PubMed ID: 23528477	2013
Kinetic analyses of trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid transport in Xenopus laevis oocytes expressing human ASCT2 and SNAT2. Nuclear medicine and biology\| PubMed ID: 23647854	2013
In vivo evidence of organic cation transporter-mediated tracheal accumulation of the anticholinergic agent ipratropium in mice. Journal of pharmaceutical sciences\| PubMed ID: 23686692	2013
Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions. Journal of pharmaceutical sciences\| PubMed ID: 23794501	2013
More relevant prediction for in vivo drug interaction of candesartan cilexetil on hepatic bile acid transporter BSEP using sandwich-cultured hepatocytes. Drug metabolism and pharmacokinetics\| PubMed ID: 23877105	2014
How does whisky lower serum urate level? Phytotherapy research : PTR\| PubMed ID: 24022993	2014
OATP transporter-mediated drug absorption and interaction. Current opinion in pharmacology\| PubMed ID: 24060700	2013
Bcrp1 transcription in mouse testis is controlled by a promoter upstream of a novel first exon (E1U) regulated by steroidogenic factor-1. Biochimica et biophysica acta\| PubMed ID: 24189494	2013
Mathematical modeling of the in vitro hepatic disposition of mycophenolic acid and its glucuronide in sandwich-cultured human hepatocytes. Molecular pharmaceutics\| PubMed ID: 24320552	2014
Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B1. Pharmaceutical research\| PubMed ID: 24549825	2014
Transport mechanisms of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan. Nuclear medicine and biology\| PubMed ID: 24607436	2014
Accumulation of trans-1-amino-3-[(18)F]fluorocyclobutanecarboxylic acid in prostate cancer due to androgen-induced expression of amino acid transporters. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging\| PubMed ID: 24943499	2014
SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria. Biopharmaceutics & drug disposition\| PubMed ID: 25044127	2014
Putative roles of organic anion transporting polypeptides (OATPs) in cell survival and progression of human cancers. Biopharmaceutics & drug disposition\| PubMed ID: 25156339	2014
In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells. The Journal of pharmacy and pharmacology\| PubMed ID: 25515305	2015
Functional cyclic AMP response element in the breast cancer resistance protein (BCRP/ABCG2) promoter modulates epidermal growth factor receptor pathway- or androgen withdrawal-mediated BCRP/... Biochimica et biophysica acta\| PubMed ID: 25615818	2015
Organic anion transporting polypeptide 2B1 expression correlates with uptake of estrone-3-sulfate and cell proliferation in estrogen receptor-positive breast cancer cells. Drug metabolism and pharmacokinetics\| PubMed ID: 25857231	2015
Involvement of Concentrative Nucleoside Transporter 1 in Intestinal Absorption of Trifluridine Using Human Small Intestinal Epithelial Cells. Journal of pharmaceutical sciences\| PubMed ID: 25900515	2015
Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis. PloS one\| PubMed ID: 25923111	2015
Kinetic Evaluation of Determinant Factors for Cellular Accumulation of Protoporphyrin IX Induced by External 5-Aminolevulinic Acid for Photodynamic Cancer Therapy. Journal of pharmaceutical sciences\| PubMed ID: 25959076	2015
Modeling approach for multiple transporters-mediated drug-drug interactions in sandwich-cultured human hepatocytes: effect of cyclosporin A on hepatic disposition of mycophenolic acid phenyl... Drug metabolism and pharmacokinetics\| PubMed ID: 25989889	2015
Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2. Journal of pharmaceutical sciences\| PubMed ID: 26037416	2015
[(14)C]Fluciclovine (alias anti-[(14)C]FACBC) uptake and ASCT2 expression in castration-resistant prostate cancer cells. Nuclear medicine and biology\| PubMed ID: 26278491	2015
Local Drug-Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 26467765	2016
OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion. Biochemical pharmacology\| PubMed ID: 26474801	2015
Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocy... Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 26502773	2016
Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydrochloride. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 26526067	2016
Interaction of Drug or Food with Drug Transporters in Intestine and Liver. Current drug metabolism\| PubMed ID: 26630906	2015
Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3. Prostaglandins & other lipid mediators\| PubMed ID: 26692285	2016
Role of OATP2A1 in PGE2 secretion from human colorectal cancer cells via exocytosis in response to oxidative stress. Experimental cell research\| PubMed ID: 26850138	2016
Carrier-Mediated Prodrug Uptake to Improve the Oral Bioavailability of Polar Drugs: An Application to an Oseltamivir Analogue. Journal of pharmaceutical sciences\| PubMed ID: 26869437	2016