Theodore R. Holman

Department of Chemistry and Biochemistry, University of California-Santa Cruz

Affiliated withUniversity of California-Santa Cruz

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2014

Other Publications

Article	Year
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase. Journal of medicinal chemistry\| PubMed ID: 12036375	2002
Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. Journal of natural products\| PubMed ID: 12608855	2003
Stopped-flow kinetic investigations of the activation of soybean lipoxygenase-1 and the influence of inhibitors on the allosteric site. Biochemistry\| PubMed ID: 12680771	2003
Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase. Biochemistry\| PubMed ID: 12731864	2003
Spectroscopic characterization of soybean lipoxygenase-1 mutants: the role of second coordination sphere residues in the regulation of enzyme activity. Biochemistry\| PubMed ID: 12809485	2003
Reactions of NO with Mn(II) and Mn(III) centers coordinated to carboxamido nitrogen: synthesis of a manganese nitrosyl with photolabile NO. Inorganic chemistry\| PubMed ID: 15106989	2004
Lipoxygenase inhibition by anadanthoflavone, a new flavonoid from the aerial parts of Anadenanthera colubrina. Planta medica\| PubMed ID: 15114507	2004
Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. Journal of medicinal chemistry\| PubMed ID: 15267244	2004
An analysis of phakellin and oroidin structures stimulated by further study of an Agelas sponge. Journal of natural products\| PubMed ID: 15332838	2004
Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1. Biochemistry\| PubMed ID: 15476400	2004
Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors. Journal of the American Chemical Society\| PubMed ID: 15535718	2004
Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinoma. The Prostate\| PubMed ID: 15666362	2005
A Re(V)-catalyzed C-N bond-forming route to human lipoxygenase inhibitors. Organic letters\| PubMed ID: 15932233	2005
Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis. Bioorganic & medicinal chemistry\| PubMed ID: 16039133	2005
Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p. Biochemistry\| PubMed ID: 16342963	2005
Novel human lipoxygenase inhibitors discovered using virtual screening with homology models. Journal of medicinal chemistry\| PubMed ID: 16480270	2006
Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases. Bioorganic & medicinal chemistry\| PubMed ID: 16500106	2006
Kinetic, spectroscopic, and structural investigations of the soybean lipoxygenase-1 first-coordination sphere mutant, Asn694Gly. Biochemistry\| PubMed ID: 16922498	2006
Pyrroloacridine alkaloids from Plakortis quasiamphiaster: structures and bioactivity. Journal of natural products\| PubMed ID: 17253856	2007
Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay. Journal of natural products\| PubMed ID: 17291044	2007
Kinetic and spectroscopic studies of N694C lipoxygenase: a probe of the substrate activation mechanism of a nonheme ferric enzyme. Journal of the American Chemical Society\| PubMed ID: 17523638	2007
Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorganic & medicinal chemistry\| PubMed ID: 17826100	2007
Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2. Bioorganic & medicinal chemistry\| PubMed ID: 17869117	2007
Pinpointing pseurotins from a marine-derived Aspergillus as tools for chemical genetics using a synthetic lethality yeast screen. Journal of natural products\| PubMed ID: 17929896	2007
Novel lipoxygenase inhibitors as neuroprotective reagents. Journal of neuroscience research\| PubMed ID: 17960827	2008
Measurement of the heme affinity for yeast dap1p, and its importance in cellular function. Biochemistry\| PubMed ID: 18031064	2007
Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry\| PubMed ID: 18547056	2008
Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation. Biochemistry\| PubMed ID: 18570379	2008
Geometric structure determination of N694C lipoxygenase: a comparative near-edge X-ray absorption spectroscopy and extended X-ray absorption fine structure study. Inorganic chemistry\| PubMed ID: 18656914	2008
Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases. Organic & biomolecular chemistry\| PubMed ID: 18972057	2008
Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. Biochemistry\| PubMed ID: 19469483	2009
Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2. Biochemistry\| PubMed ID: 19645454	2009
Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1. Bioorganic & medicinal chemistry\| PubMed ID: 19716306	2009
Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. Journal of natural products\| PubMed ID: 19848434	2009
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1. Journal of medicinal chemistry\| PubMed ID: 20866075	2010
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. Journal of medicinal chemistry\| PubMed ID: 21739938	2011
Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation. Molecular pharmacology\| PubMed ID: 22155783	2012
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction. Molecular and cellular endocrinology\| PubMed ID: 22502743	2012
Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation. Journal of lipid research\| PubMed ID: 22984144	2012
Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23070608	2013
Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Annals of neurology\| PubMed ID: 23192915	2013
Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases. Bioorganic & medicinal chemistry\| PubMed ID: 23669189	2013
Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy. PloS one\| PubMed ID: 23826084	2013
Kinetic and structural investigations into the allosteric and pH effect on the substrate specificity of human epithelial 15-lipoxygenase-2. Biochemistry\| PubMed ID: 24171444	2013