Thomas C. Irving

Thomas C. Irving

BioCAT, Illinois Institute of Technology

Affiliated withIllinois Institute of Technology

Research Area

Biography

Thomas Irving is Professor of Biology and Physics in the Department of Biological Sciences at the Illinois Institute of Technology in Chicago, Illinois. He received his B.Sc., M.Sc, and Ph.D. degrees from the University of Guelph, Ontario Canada.

He began his career studying muscle structure and function using small-angle X-ray diffraction of muscle as an undergraduate, continuing in his graduate studies. After a brief detour into cell biology at the University of Texas at Austin, he returned to X-ray diffraction as a staff scientist at the Cornell High Energy Synchrotron Source (CHESS), Ithaca NY. Here he received training in using synchrotron radiation for biophysical studies and worked with well-known muscle researchers including the late Hugh Huxley (Brandeis) and Michael Reedy (Duke University) on muscle diffraction studies.

In 1994 he moved to the Illinois Institute of Technology in Chicago to help launch the Biophysics Collaborative Access Team (BioCAT) project. BioCAT is organized as a NIH–supported Biotechnology Research Resource dedicated to structural studies of non-crystalline biological materials using Small and Wide-angle Fiber Diffraction and Macromolecular Small-Angle X-ray Scattering (SAXS) with emphasis on time and spatially resolved applications. The heart of the facility is Beamline 18ID, located on Sector 18 at the Advanced Photon Source (APS), Argonne National Laboratory in Argonne, IL. Professor Irving has been the Director of BioCAT and Principal Investigator of the P41 grant that funds it since 2001. He works with a number of investigator groups around the country and internationally to study the structure and function of muscle sarcomeric proteins especially in relation to muscle regulation.

JoVE Journal Publications

ArticleTotal : 1
Year
X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease
Publication title

Cited by 20

2019

Other Publications

Article
Year
Synchrotron X-ray imaging reveals a correlation of tumor copper speciation with Clioquinol's anticancer activity.

Journal of cellular biochemistry| PubMed ID: 19530227

2009
2003
Microfibrillar structure of type I collagen in situ.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 16751282

2006
2007
2008
Structure of flexible filamentous plant viruses.

Journal of virology| PubMed ID: 18667514

2008
X-ray scattering study of actin polymerization nuclei assembled by tandem W domains.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 18669664

2008
Cost-effective EMCCD-based detector for time-resolved biological SAXS applications.

Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment| PubMed ID: 18997878

2007
2009
2009
2009
Myofilament length dependent activation.

Journal of molecular and cellular cardiology| PubMed ID: 20053351

2010
X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 21148419

2011
Shape of tropoelastin, the highly extensible protein that controls human tissue elasticity.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 21368178

2011
Myosin head orientation: a structural determinant for the Frank-Starling relationship.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 21460195

2011
2011
2011
Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology| PubMed ID: 21885653

2011
2011
2012
2012
Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.

Archives of biochemistry and biophysics| PubMed ID: 23246787

2013
2012
The length-tension curve in muscle depends on lattice spacing.

Proceedings. Biological sciences / The Royal Society| PubMed ID: 23843386

2013
2013
2013
High-speed detector for time-resolved diffraction studies.

Journal of physics. Conference series| PubMed ID: 24489595

2013
2014
Modulation of frustration in folding by sequence permutation.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 25002512

2014
Hugh E. Huxley: the compleat biophysicist.

Biophysical journal| PubMed ID: 25296301

2014
Elastic proteins in the flight muscle of Manduca sexta.

Archives of biochemistry and biophysics| PubMed ID: 25602701

2015
Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 26124132

2015
2015
Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 26858417

2016
X-ray diffraction from nonuniformly stretched helical molecules.

Journal of applied crystallography| PubMed ID: 27275136

2016
2004
2016
2016
2017
2018
2018
Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified mice.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 29463717

2018
Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 30104387

2018
2018
Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle.

International journal of molecular sciences| PubMed ID: 30200618

2018
Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 30249654

2018
Thick-Filament Extensibility in Intact Skeletal Muscle.

Biophysical journal| PubMed ID: 30266320

2018
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology| PubMed ID: 30365366

2019
Getting into the thick (and thin) of it.

The Journal of general physiology| PubMed ID: 30792184

2019
2019
2019
Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 31110001

2019