Thomas E. Lane

Department of Molecular Biology and Biochemistry, University of California, Irvine

Affiliated withUniversity of California, Irvine University of Utah

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 14	2011
Publication title Cited by 5	2015

Other Publications

Article	Year
Lack of nitric oxide synthase type 2 (NOS2) results in reduced neuronal apoptosis and mortality following mouse hepatitis virus infection of the central nervous system. Journal of neurovirology\| PubMed ID: 11847593	2002
IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11907072	2002
Mouse hepatitis virus infection of the central nervous system: chemokine-mediated regulation of host defense and disease. Viral immunology\| PubMed ID: 12081011	2002
Functional expression of chemokine receptor CCR5 on CD4(+) T cells during virus-induced central nervous system disease. Journal of virology\| PubMed ID: 12477824	2003
CC chemokine ligand 3 (CCL3) regulates CD8(+)-T-cell effector function and migration following viral infection. Journal of virology\| PubMed ID: 12634360	2003
Adenovirus-mediated expression of CXCL10 in the central nervous system results in T-cell recruitment and limited neuropathology. Journal of neurovirology\| PubMed ID: 12775415	2003
Functional analysis of the CC chemokine receptor 5 (CCR5) on virus-specific CD8+ T cells following coronavirus infection of the central nervous system. Virology\| PubMed ID: 12919745	2003
Effect of anti-CXCL10 monoclonal antibody on herpes simplex virus type 1 keratitis and retinal infection. Journal of virology\| PubMed ID: 12941914	2003
Measles virus infection induces chemokine synthesis by neurons. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12960336	2003
Reducing inflammation decreases secondary degeneration and functional deficit after spinal cord injury. Experimental neurology\| PubMed ID: 14637115	2003
CXC chemokine ligand 10 controls viral infection in the central nervous system: evidence for a role in innate immune response through recruitment and activation of natural killer cells. Journal of virology\| PubMed ID: 14694090	2004
Distinct roles for IP-10/CXCL10 in three animal models, Theiler's virus infection, EAE, and MHV infection, for multiple sclerosis: implication of differing roles for IP-10. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 14760949	2004
Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple scler... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15034013	2004
Remyelination, axonal sparing, and locomotor recovery following transplantation of glial-committed progenitor cells into the MHV model of multiple sclerosis. Experimental neurology\| PubMed ID: 15144852	2004
Enhanced T cell proliferation in mice lacking the p85beta subunit of phosphoinositide 3-kinase. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15153476	2004
The CC chemokine ligand 3 regulates CD11c+CD11b+CD8alpha- dendritic cell maturation and activation following viral infection of the central nervous system: implications for a role in T cell ... Virology\| PubMed ID: 15327893	2004
Consequences of CXCL10 and IL-6 induction by the murine IFN-alpha1 transgene in ocular herpes simplex virus type 1 infection. Immunologic research\| PubMed ID: 15477660	2004
Differential roles of CCL2 and CCR2 in host defense to coronavirus infection. Virology\| PubMed ID: 15518805	2004
Neutralization of chemokines RANTES and MIG increases virus antigen expression and spinal cord pathology during Theiler's virus infection. International immunology\| PubMed ID: 15824069	2005
Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion. Science (New York, N.Y.)\| PubMed ID: 15933199	2005
Transplantation of glial-committed progenitor cells into a viral model of multiple sclerosis induces remyelination in the absence of an attenuated inflammatory response. Experimental neurology\| PubMed ID: 16297915	2006
The chemokines CXCL9 and CXCL10 promote a protective immune response but do not contribute to cardiac inflammation following infection with Trypanosoma cruzi. Infection and immunity\| PubMed ID: 16368965	2006
The CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi. Infection and immunity\| PubMed ID: 16368966	2006
Coronavirus infection of the central nervous system: host-virus stand-off. Nature reviews. Microbiology\| PubMed ID: 16415928	2006
Abnormal immune response of CCR5-deficient mice to ocular infection with herpes simplex virus type 1. The Journal of general virology\| PubMed ID: 16476970	2006
Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS. European journal of immunology\| PubMed ID: 16479546	2006
Chemokine CC receptor 2 is important for acute control of cardiac parasitism but does not contribute to cardiac inflammation after infection with Trypanosoma cruzi. The Journal of infectious diseases\| PubMed ID: 16652288	2006
Dengue virus induces expression of CXC chemokine ligand 10/IFN-gamma-inducible protein 10, which competitively inhibits viral binding to cell surface heparan sulfate. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16920957	2006
NKG2D signaling and host defense after mouse hepatitis virus infection of the central nervous system. Advances in experimental medicine and biology\| PubMed ID: 17037561	2006
SjÃ¶gren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17071741	2006
T cell antiviral effector function is not dependent on CXCL10 following murine coronavirus infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17142734	2006
T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. Blood\| PubMed ID: 17164340	2007
Anti-viral effector T cell responses and trafficking are not dependent upon DRAK2 signaling following viral infection of the central nervous system. Autoimmunity\| PubMed ID: 17364498	2007
Expression of CXC chemokine ligand 10 from the mouse hepatitis virus genome results in protection from viral-induced neurological and liver disease. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17617609	2007
Therapeutic neutralization of CXCL10 decreases secondary degeneration and functional deficit after spinal cord injury in mice. Regenerative medicine\| PubMed ID: 17907930	2007
DRAK2 regulates memory T cell responses following murine coronavirus infection. Autoimmunity\| PubMed ID: 17966037	2007
Evidence for differential roles for NKG2D receptor signaling in innate host defense against coronavirus-induced neurological and liver disease. Journal of virology\| PubMed ID: 18094157	2008
CCR1 deficiency increases susceptibility to fatal coronavirus infection of the central nervous system. Viral immunology\| PubMed ID: 18158733	2007
NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis. Journal of virology\| PubMed ID: 18160433	2008
The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease. The Journal of experimental medicine\| PubMed ID: 18347102	2008
Mouse hepatitis virus infection of the CNS: a model for defense, disease, and repair. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 18508518	2008
Generation of a protective T-cell response following coronavirus infection of the central nervous system is not dependent on IL-12/23 signaling. Viral immunology\| PubMed ID: 18570589	2008
CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy. European journal of immunology\| PubMed ID: 18624292	2008
Insertion of the CXC chemokine ligand 9 (CXCL9) into the mouse hepatitis virus genome results in protection from viral-induced encephalitis and hepatitis. Virology\| PubMed ID: 18973912	2008
IFN-gamma-mediated suppression of coronavirus replication in glial-committed progenitor cells. Virology\| PubMed ID: 19059617	2009
Endogenous remyelination is induced by transplant rejection in a viral model of multiple sclerosis. Journal of neuroimmunology\| PubMed ID: 19477025	2009
Cutting edge: the chemokine receptor CXCR3 retains invariant NK T cells in the thymus. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19620294	2009
CXCL10 and trafficking of virus-specific T cells during coronavirus-induced demyelination. Autoimmunity\| PubMed ID: 19626487	2009
A protective role for ELR+ chemokines during acute viral encephalomyelitis. PLoS pathogens\| PubMed ID: 19893623	2009
The Biology of Persistent Infection: Inflammation and Demyelination following Murine Coronavirus Infection of the Central Nervous System. Current immunology reviews\| PubMed ID: 19946572	2009
CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis. Nature neuroscience\| PubMed ID: 20154684	2010
The pathogenesis of murine coronavirus infection of the central nervous system. Critical reviews in immunology\| PubMed ID: 20370625	2010
Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20534452	2010
CXCR2 signaling protects oligodendrocytes and restricts demyelination in a mouse model of viral-induced demyelination. PloS one\| PubMed ID: 20596532	2010
Myelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20610741	2010
Cell replacement therapies to promote remyelination in a viral model of demyelination. Journal of neuroimmunology\| PubMed ID: 20627412	2010
Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20668193	2010
The role of chemokines during viral infection of the CNS. PLoS pathogens\| PubMed ID: 20686655	2010
Impaired immune responses following spinal cord injury lead to reduced ability to control viral infection. Experimental neurology\| PubMed ID: 20832407	2010
G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands. Blood\| PubMed ID: 21224471	2011
Inflammation induced by infection potentiates tau pathological features in transgenic mice. The American journal of pathology\| PubMed ID: 21531375	2011
CXCR2 signaling protects oligodendrocyte progenitor cells from IFN-Î³/CXCL10-mediated apoptosis. Glia\| PubMed ID: 21656856	2011
Importance of the CCR5-CCL5 axis for mucosal Trypanosoma cruzi protection and B cell activation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21715689	2011
CXCR4 signaling regulates remyelination by endogenous oligodendrocyte progenitor cells in a viral model of demyelination. Glia\| PubMed ID: 21830237	2011
Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21876153	2011