Tobias Krojer

Structural Genomics Consortium, University of Oxford

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 78	2021

Other Publications

Article	Year
Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6. Journal of molecular biology\| PubMed ID: 20684070	2010
Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6. Journal of molecular biology\| PubMed ID: 20685276	2010
Structural and mechanistic studies on γ-butyrobetaine hydroxylase. Chemistry & biology\| PubMed ID: 21168767	2010
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21508329	2011
Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects. Journal of synchrotron radiation\| PubMed ID: 21525647	2011
Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function. Biochemistry\| PubMed ID: 22642810	2012
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. Journal of medicinal chemistry\| PubMed ID: 22724510	2012
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases. The Journal of biological chemistry\| PubMed ID: 23349464	2013
Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations. Structure (London, England : 1993)\| PubMed ID: 23791943	2013
Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature\| PubMed ID: 24814345	2014
Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25049398	2014
Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design. Human molecular genetics\| PubMed ID: 26199317	2015
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor. MedChemComm\| PubMed ID: 26682034	2014
5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. Chemical science\| PubMed ID: 26682036	2013
Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation. Chemistry & biology\| PubMed ID: 26687144	2015
Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors. Journal of medicinal chemistry\| PubMed ID: 26699912	2016
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. Journal of medicinal chemistry\| PubMed ID: 26741168	2016
An overview of heavy-atom derivatization of protein crystals. Acta crystallographica. Section D, Structural biology\| PubMed ID: 26960118	2016
Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop. Structure (London, England : 1993)\| PubMed ID: 27050687	2016
A generic protocol for protein crystal dehydration using the HC1b humidity controller. Acta crystallographica. Section D, Structural biology\| PubMed ID: 27139626	2016
Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin. Cell reports\| PubMed ID: 27926874	2016
Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16. The Biochemical journal\| PubMed ID: 28057719	2017
Gentle, fast and effective crystal soaking by acoustic dispensing. Acta crystallographica. Section D, Structural biology\| PubMed ID: 28291760	2017
Proper modelling of ligand binding requires an ensemble of bound and unbound states. Acta crystallographica. Section D, Structural biology\| PubMed ID: 28291761	2017
The XChemExplorer graphical workflow tool for routine or large-scale protein-ligand structure determination. Acta crystallographica. Section D, Structural biology\| PubMed ID: 28291762	2017
Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites. Structural dynamics (Melville, N.Y.)\| PubMed ID: 28345007	2017
A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nature communications\| PubMed ID: 28436492	2017
A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chemical science\| PubMed ID: 29910922	2016
Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening. Methods in enzymology\| PubMed ID: 30390801	2018
A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase. ACS catalysis\| PubMed ID: 30984471	2019
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. Journal of the American Chemical Society\| PubMed ID: 31060360	2019
Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nature communications\| PubMed ID: 31659163	2019
Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism. ChemMedChem\| PubMed ID: 32812371	2020
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease. Nature communications\| PubMed ID: 33028810	2020
Discovery of allosteric binding sites by crystallographic fragment screening. Current opinion in structural biology\| PubMed ID: 33171388	2020
Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking. bioRxiv : the preprint server for biology\| PubMed ID: 33269349	2020
The low-cost Shifter microscope stage transforms the speed and robustness of protein crystal harvesting. Acta crystallographica. Section D, Structural biology\| PubMed ID: 33404526	2021
Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia. ACS chemical biology\| PubMed ID: 33724769	2021
Structure and activation mechanism of the human liver-type glutaminase GLS2. Biochimie\| PubMed ID: 33746066	2021
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Science advances\| PubMed ID: 33853786	2021