Uwe Christians

iC42 Clinical Research and Development, University of Colorado, Anschutz Medical Campus

Affiliated withUniversity of Colorado, Anschutz Medical Campus

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 28	2015

Other Publications

Article	Year
Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 11891440	2002
Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 12183671	2002
Mechanisms of clinically relevant drug interactions associated with tacrolimus. Clinical pharmacokinetics\| PubMed ID: 12190331	2002
Ultrasound-induced mild hyperthermia as a novel approach to increase drug uptake in brain microvessel endothelial cells. Pharmaceutical research\| PubMed ID: 12240937	2002
Cyclosporine can increase isoflurane MAC. Anesthesia and analgesia\| PubMed ID: 12351270	2002
Sirolimus (rapamycin) monotherapy prevents graft vascular disease in nonhuman primate recipients of orthotopic aortic allografts. Circulation\| PubMed ID: 12719285	2003
CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 14569063	2004
Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury. JPEN. Journal of parenteral and enteral nutrition\| PubMed ID: 14621120	2003
Preliminary in vivo pharmacokinetic and pharmacodynamic evaluation of a novel calcineurin-independent inhibitor of NFAT. Transplant international : official journal of the European Society for Organ Transplantation\| PubMed ID: 14735234	2004
Transplantation: toxicokinetics and mechanisms of toxicity of cyclosporine and macrolides. Current opinion in investigational drugs (London, England : 2000)\| PubMed ID: 14758767	2003
Biochemical mechanisms of cyclosporine neurotoxicity. Molecular interventions\| PubMed ID: 15087483	2004
Transport proteins and intestinal metabolism: P-glycoprotein and cytochrome P4503A. Therapeutic drug monitoring\| PubMed ID: 15228147	2004
Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. British journal of pharmacology\| PubMed ID: 15339861	2004
Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Therapeutic drug monitoring\| PubMed ID: 15385839	2004
Cyclosporine toxicity in immunosuppressed streptozotocin-diabetic nonhuman primates. Toxicology\| PubMed ID: 15590127	2005
The effect of soluble complement receptor type 1 on acute humoral xenograft rejection in hDAF-transgenic pig-to-primate life-supporting kidney xenografts. Xenotransplantation\| PubMed ID: 15598270	2005
Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Drug metabolism and pharmacokinetics\| PubMed ID: 15618725	2003
Greater free plasma VEGF and lower soluble VEGF receptor-1 in acute mountain sickness. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 15649874	2005
Adding sirolimus to tacrolimus-based immunosuppression in pediatric renal transplant recipients reduces tacrolimus exposure. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 15996252	2005
Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Transplantation\| PubMed ID: 16003227	2005
Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 16009444	2005
Development and validation of a high-throughput assay for quantification of the proliferation inhibitor ABT-578 using LC/LC-MS/MS in blood and tissue samples. Therapeutic drug monitoring\| PubMed ID: 16306853	2005
Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the blood. Therapeutic drug monitoring\| PubMed ID: 16404806	2005
Active drug transport of immunosuppressants: new insights for pharmacokinetics and pharmacodynamics. Therapeutic drug monitoring\| PubMed ID: 16418692	2006
Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nature medicine\| PubMed ID: 16491083	2006
Risk of impaired coagulation in warfarin patients ascending to altitude (>2400 m). High altitude medicine & biology\| PubMed ID: 16544965	2006
Unexpectedly high exposure to enteric-coated mycophenolate sodium upon once-daily dosing. Pediatric nephrology (Berlin, Germany)\| PubMed ID: 16721583	2006
Impact of organ preservation using HTK for graft flush and subsequent storage in UW in rat kidney transplantation. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes\| PubMed ID: 16847398	2006
Functional interactions between P-glycoprotein and CYP3A in drug metabolism. Expert opinion on drug metabolism & toxicology\| PubMed ID: 16863430	2005
Pharmacokinetics of pyridostigmine in a child with postural tachycardia syndrome. Pediatrics\| PubMed ID: 17015495	2006
Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 17070115	2007
Cyclosporin twice or three times daily dosing in pediatric transplant patients - it is not the same! Pediatric transplantation\| PubMed ID: 17096765	2006
Prolonged survival of porcine hepatocytes in cynomolgus monkeys. Gastroenterology\| PubMed ID: 17241882	2007
HPLC-atmospheric pressure chemical ionization MS/MS for quantification of 15-F2t-isoprostane in human urine and plasma. Clinical chemistry\| PubMed ID: 17259231	2007
Development and validation of an assay for the quantification of 11 nucleotides using LC/LC-electrospray ionization-MS. Analytical biochemistry\| PubMed ID: 17475198	2007
Pharmacokinetics of enteric-coated mycophenolate sodium in stable liver transplant recipients. Clinical transplantation\| PubMed ID: 17488394	2007
Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus. Journal of mass spectrometry : JMS\| PubMed ID: 17511017	2007
Serotonin transporter protein in pulmonary hypertensive rats treated with atorvastatin. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 17575010	2007
Comparison of lung proteome profiles in two rodent models of pulmonary arterial hypertension. Proteomics\| PubMed ID: 17623304	2007
Identification of everolimus metabolite patterns in trough blood samples of kidney transplant patients. Therapeutic drug monitoring\| PubMed ID: 17898649	2007
Crossreactivity of isolated everolimus metabolites with the Innofluor Certican immunoassay for therapeutic drug monitoring of everolimus. Therapeutic drug monitoring\| PubMed ID: 18043471	2007
Pharmacokinetics of mycophenolate mofetil and sirolimus in children. Therapeutic drug monitoring\| PubMed ID: 18367972	2008
Toxicodynamic therapeutic drug monitoring of immunosuppressants: promises, reality, and challenges. Therapeutic drug monitoring\| PubMed ID: 18367974	2008
A metabonomic and proteomic analysis of changes in IMCD3 cells chronically adapted to hypertonicity. Nephron. Physiology\| PubMed ID: 18460876	2008
Characterization of sirolimus metabolites in pediatric solid organ transplant recipients. Pediatric transplantation\| PubMed ID: 18482220	2009
Oxidative in vitro metabolism of liquiritigenin, a bioactive compound isolated from the Chinese herbal selective estrogen beta-receptor agonist MF101. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 18669586	2008
An automated, highly sensitive LC-MS/MS assay for the quantification of the opiate antagonist naltrexone and its major metabolite 6beta-naltrexol in dog and human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 18805072	2008
Comparison of the quantification of acetaminophen in plasma, cerebrospinal fluid and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 23670126	2013
The pharmacokinetics of Biolimus A9 after elution from the Nobori stent in patients with coronary artery disease: the NOBORI PK study. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions\| PubMed ID: 19016466	2008
Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics... Anesthesia and analgesia\| PubMed ID: 19095843	2009
Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function. Chemical research in toxicology\| PubMed ID: 19099400	2009
Metabolic profiles in urine reflect nephrotoxicity of sirolimus and cyclosporine following rat kidney transplantation. Nephron. Experimental nephrology\| PubMed ID: 19293597	2009
Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m. Free radical biology & medicine\| PubMed ID: 19303436	2009
Consequences of delayed pump infusion line change in patients with type 1 diabetes mellitus treated with continuous subcutaneous insulin infusion. Journal of diabetes and its complications\| PubMed ID: 19395280	2010
Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture. Biomedical chromatography : BMC\| PubMed ID: 19517424	2009
Identification and characterization of a bacterial cytochrome P450 for the metabolism of diclofenac. Applied microbiology and biotechnology\| PubMed ID: 19636551	2010
Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells. British journal of pharmacology\| PubMed ID: 19663881	2009
Irradiation alters selection for oncogenic mutations in hematopoietic progenitors. Cancer research\| PubMed ID: 19738065	2009
Development and validation of a semi-automated assay for the highly sensitive quantification of Biolimus A9 in human whole blood using high-performance liquid chromatography-tandem mass spec... Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 19762292	2009
Association of immunosuppressant-induced protein changes in the rat kidney with changes in urine metabolite patterns: a proteo-metabonomic study. Journal of proteome research\| PubMed ID: 19994912	2010
Immunosuppressant neurotoxicity in rat brain models: oxidative stress and cellular metabolism. Chemical research in toxicology\| PubMed ID: 20148532	2010
Bioequivalence testing of immunosuppressants: concepts and misconceptions. Kidney international. Supplement\| PubMed ID: 20150904	2010
Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. Breast cancer research : BCR\| PubMed ID: 20205716	2010
Characterization of potential allergens in fenugreek (Trigonella foenum-graecum) using patient sera and MS-based proteomic analysis. Journal of proteomics\| PubMed ID: 20219717	2010
Randomized, double-blind, placebo-controlled, single intravenous dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics of the novel coronary smooth muscle cell pro... Journal of clinical pharmacology\| PubMed ID: 20305057	2011
Polymer-free biolimus a9-coated stent demonstrates more sustained intimal inhibition, improved healing, and reduced inflammation compared with a polymer-coated sirolimus-eluting cypher stent... Circulation. Cardiovascular interventions\| PubMed ID: 20407114	2010
Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice. Brain research\| PubMed ID: 20599427	2010
Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose. British journal of clinical pharmacology\| PubMed ID: 20653677	2010
Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritability. Twin research and human genetics : the official journal of the International Society for Twin Studies\| PubMed ID: 20874462	2010
The pharmacokinetics of Biolimus A9 after elution from the BioMatrix II stent in patients with coronary artery disease: the Stealth PK Study. European journal of clinical pharmacology\| PubMed ID: 20963405	2011
Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology\| PubMed ID: 21075140	2011
Urinary catalytic iron in patients with type 2 diabetes without microalbuminuria--a substudy of the ACCORD Trial. Clinical chemistry\| PubMed ID: 21159897	2011
Interpreting mammalian target of rapamycin and cell growth inhibition in a genetically engineered mouse model of Nf1-deficient astrocytes. Molecular cancer therapeutics\| PubMed ID: 21216928	2011
Pharmacokinetics of single-dose intravenous ketorolac in infants aged 2-11 months. Anesthesia and analgesia\| PubMed ID: 21233498	2011
Biomarkers of immunosuppressant organ toxicity after transplantation: status, concepts and misconceptions. Expert opinion on drug metabolism & toxicology\| PubMed ID: 21241200	2011
Quantification of 15-F2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared. Rapid communications in mass spectrometry : RCM\| PubMed ID: 21259353	2011
Liquid chromatography and mass spectrometry in food allergen detection. Journal of food protection\| PubMed ID: 21333155	2011
A sensitive assay for the quantification of morphine and its active metabolites in human plasma and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry. Analytical and bioanalytical chemistry\| PubMed ID: 21400080	2011
How unbiased is non-targeted metabolomics and is targeted pathway screening the solution? Current pharmaceutical biotechnology\| PubMed ID: 21466457	2011
Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: a combined proteomic and metabolomic study. International journal of cancer. Journal international du cancer\| PubMed ID: 21509784	2011
Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns. Journal of mass spectrometry : JMS\| PubMed ID: 21671437	2011
A high-throughput U-HPLC-MS/MS assay for the quantification of mycophenolic acid and its major metabolites mycophenolic acid glucuronide and mycophenolic acid acyl-glucuronide in human plasm... Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 21839692	2012
A low blood volume LC-MS/MS assay for the quantification of fentanyl and its major metabolites norfentanyl and despropionyl fentanyl in children. Journal of separation science\| PubMed ID: 21916010	2011
Influence of SLCO1B1 polymorphisms on the drug-drug interaction between darunavir/ritonavir and pravastatin. Journal of clinical pharmacology\| PubMed ID: 22174437	2012
Neurobehavioural activation during peripheral immunosuppression. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)\| PubMed ID: 22217400	2013
Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. The Journal of clinical investigation\| PubMed ID: 22269324	2012
MF101: a multi-component botanical selective estrogen receptor beta modulator for the treatment of menopausal vasomotor symptoms. Expert opinion on investigational drugs\| PubMed ID: 22616988	2012
Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy. Cardiovascular research\| PubMed ID: 23015639	2013
A multi-center phase Ib study of oxaliplatin (NSC#266046) in combination with fluorouracil and leucovorin in pediatric patients with advanced solid tumors. Pediatric blood & cancer\| PubMed ID: 23024067	2013
Low-salt diet and cyclosporine nephrotoxicity: changes in kidney cell metabolism. Journal of proteome research\| PubMed ID: 23057591	2012
Everolimus and sirolimus in combination with cyclosporine have different effects on renal metabolism in the rat. PloS one\| PubMed ID: 23118926	2012
Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury. PloS one\| PubMed ID: 23185570	2012
Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism. Xenobiotica; the fate of foreign compounds in biological systems\| PubMed ID: 23278282	2013
Proteomics and metabolomics in renal transplantation-quo vadis? Transplant international : official journal of the European Society for Organ Transplantation\| PubMed ID: 23350848	2013
Development and validation of an LC-MS/MS assay for the quantification of the trans-methylation pathway intermediates S-adenosylmethionine and S-adenosylhomocysteine in human plasma. Clinica chimica acta; international journal of clinical chemistry\| PubMed ID: 23499573	2013
Genetic and structure-function studies of missense mutations in human endothelial lipase. PloS one\| PubMed ID: 23536757	2013
Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats. Inflammation\| PubMed ID: 23616184	2013
Multidrug resistance-associated protein 2 (MRP2/ABCC2) haplotypes significantly affect the pharmacokinetics of tacrolimus in kidney transplant recipients. Clinical pharmacokinetics\| PubMed ID: 23633119	2013
Mass Spectrometry-Based Multiplexing for the Analysis of Biomarkers in Drug Development and Clinical Diagnostics- How Much is too Much? Microchemical journal, devoted to the application of microtechniques in all branches of science\| PubMed ID: 23645936	2012
Emerging technologies: polymer-free phospholipid encapsulated sirolimus nanocarriers for the controlled release of drug from a stent-plus-balloon or a stand-alone balloon catheter. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology\| PubMed ID: 23685303	2013
Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease. BMC nephrology\| PubMed ID: 23902712	2013
Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 24029553	2013
Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharmaceutics & drug disposition\| PubMed ID: 24030928	2013
Cyclosporine induces endothelial cell release of complement-activating microparticles. Journal of the American Society of Nephrology : JASN\| PubMed ID: 24092930	2013
CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathy. Journal of the American Society of Nephrology : JASN\| PubMed ID: 24262796	2014
Bioactive lipid mediators in polycystic kidney disease. Journal of lipid research\| PubMed ID: 24343898	2013
Mycophenolate mofetil enhances the negative effects of sirolimus and tacrolimus on rat kidney cell metabolism. PloS one\| PubMed ID: 24497939	2014
Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs. Anesthesiology\| PubMed ID: 24809976	2014
Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-response relationships, and clinical outcomes. Transplant immunology\| PubMed ID: 24861504	2014
Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1(+) leukemia. American journal of hematology\| PubMed ID: 24891015	2014
Fatty acid desaturation index in human plasma: comparison of different analytical methodologies for the evaluation of diet effects. Analytical and bioanalytical chemistry\| PubMed ID: 25116600	2014
Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1. Therapeutic drug monitoring\| PubMed ID: 25162215	2015
Endothelial dysfunction and oxidative stress in polycystic kidney disease. American journal of physiology. Renal physiology\| PubMed ID: 25234311	2014
Neurobehavioral consequences of small molecule-drug immunosuppression. Neuropharmacology\| PubMed ID: 25529273	2015
A high-performance liquid chromatography-tandem mass spectrometry-based targeted metabolomics kidney dysfunction marker panel in human urine. Clinica chimica acta; international journal of clinical chemistry\| PubMed ID: 25871999	2015
Everolimus and sirolimus in transplantation-related but different. Expert opinion on drug safety\| PubMed ID: 25912929	2015
Long-term cross-validation of everolimus therapeutic drug monitoring assays: the Zortracker study. Therapeutic drug monitoring\| PubMed ID: 25970506	2015
Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 26224879	2015
Memory-updating abrogates extinction of learned immunosuppression. Brain, behavior, and immunity\| PubMed ID: 26386321	2015
ANALYTICAL ASPECTS OF THE IMPLEMENTATION OF BIOMARKERS IN CLINICAL TRANSPLANTATION. Therapeutic drug monitoring\| PubMed ID: 26418704	2015