Vadim Cherezov The Bridge Institute University of Southern California Biography Publications Institution JoVE Articles Vadim Cherezov has not added a biography. If you are Vadim Cherezov and would like to personalize this page please email our Author Liaison for assistance. Publications Serial Femtosecond Crystallography of Membrane Proteins Advances in Experimental Medicine and Biology. 2016 | Pubmed ID: 27553241 Serial Femtosecond Crystallography Datasets from G Protein-coupled Receptors Scientific Data. 2016 | Pubmed ID: 27479354 X-ray Laser Diffraction for Structure Determination of the Rhodopsin-arrestin Complex Scientific Data. 2016 | Pubmed ID: 27070998 The Fragment Molecular Orbital Method Reveals New Insight into the Chemical Nature of GPCR-Ligand Interactions Journal of Chemical Information and Modeling. Jan, 2016 | Pubmed ID: 26642258 Serial Femtosecond X-ray Diffraction of Enveloped Virus Microcrystals Structural Dynamics (Melville, N.Y.). Jul, 2015 | Pubmed ID: 26798819 Ternary Structure Reveals Mechanism of a Membrane Diacylglycerol Kinase Nature Communications. 2015 | Pubmed ID: 26673816 The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor Structure (London, England : 1993). Dec, 2015 | Pubmed ID: 26526853 Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor The Journal of Biological Chemistry. Dec, 2015 | Pubmed ID: 26420482 Serial Femtosecond Crystallography of Soluble Proteins in Lipidic Cubic Phase IUCrJ. Sep, 2015 | Pubmed ID: 26306196 Crystal Structure of Rhodopsin Bound to Arrestin by Femtosecond X-ray Laser Nature. Jul, 2015 | Pubmed ID: 26200343 A Novel Inert Crystal Delivery Medium for Serial Femtosecond Crystallography IUCrJ. Jul, 2015 | Pubmed ID: 26177184 Fluorescence Recovery After Photobleaching in Lipidic Cubic Phase (LCP-FRAP): A Precrystallization Assay for Membrane Proteins Methods in Enzymology. 2015 | Pubmed ID: 25950976 Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography Cell. May, 2015 | Pubmed ID: 25913193 Lipidic Cubic Phase Serial Millisecond Crystallography Using Synchrotron Radiation IUCrJ. Mar, 2015 | Pubmed ID: 25866654 Two Disparate Ligand-binding Sites in the Human P2Y1 Receptor Nature. Apr, 2015 | Pubmed ID: 25822790 GPCR Structure, Function, Drug Discovery and Crystallography: Report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014 Naunyn-Schmiedeberg's Archives of Pharmacology. Aug, 2015 | Pubmed ID: 25772061 Structural Basis for Bifunctional Peptide Recognition at Human δ-opioid Receptor Nature Structural & Molecular Biology. Mar, 2015 | Pubmed ID: 25686086 Structural Biology. Crystal Structure of the Chemokine Receptor CXCR4 in Complex with a Viral Chemokine Science (New York, N.Y.). Mar, 2015 | Pubmed ID: 25612609 Generic GPCR Residue Numbers - Aligning Topology Maps While Minding the Gaps Trends in Pharmacological Sciences. Jan, 2015 | Pubmed ID: 25541108 Two Classes of Cholesterol Binding Sites for the β2AR Revealed by Thermostability and NMR Biophysical Journal. Nov, 2014 | Pubmed ID: 25418299 Constitutive Phospholipid Scramblase Activity of a G Protein-coupled Receptor Nature Communications. 2014 | Pubmed ID: 25296113 Preparation of Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography Nature Protocols. Sep, 2014 | Pubmed ID: 25122522 Structural Basis for Smoothened Receptor Modulation and Chemoresistance to Anticancer Drugs Nature Communications. 2014 | Pubmed ID: 25008467 Femtosecond Crystallography of Membrane Proteins in the Lipidic Cubic Phase Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jul, 2014 | Pubmed ID: 24914147 Agonist-bound Structure of the Human P2Y12 Receptor Nature. May, 2014 | Pubmed ID: 24784220 Allosteric Sodium in Class A GPCR Signaling Trends in Biochemical Sciences. May, 2014 | Pubmed ID: 24767681 Structure of the Human P2Y12 Receptor in Complex with an Antithrombotic Drug Nature. May, 2014 | Pubmed ID: 24670650 Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator Science (New York, N.Y.). Apr, 2014 | Pubmed ID: 24603153 Lipidic Cubic Phase Injector Facilitates Membrane Protein Serial Femtosecond Crystallography Nature Communications. 2014 | Pubmed ID: 24525480 Molecular Control of δ-opioid Receptor Signalling Nature. Feb, 2014 | Pubmed ID: 24413399 Functional Assay for T4 Lysozyme-engineered G Protein-coupled Receptors with an Ion Channel Reporter Structure (London, England : 1993). Jan, 2014 | Pubmed ID: 24268646 Serial Femtosecond Crystallography of G Protein-coupled Receptors Science (New York, N.Y.). Dec, 2013 | Pubmed ID: 24357322 The Role of a Sodium Ion Binding Site in the Allosteric Modulation of the A(2A) Adenosine G Protein-coupled Receptor Structure (London, England : 1993). Dec, 2013 | Pubmed ID: 24210756 Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex Science (New York, N.Y.). Sep, 2013 | Pubmed ID: 24030490 Structure-based Ligand Discovery Targeting Orthosteric and Allosteric Pockets of Dopamine Receptors Molecular Pharmacology. Dec, 2013 | Pubmed ID: 24021214 Structure of the Human Glucagon Class B G-protein-coupled Receptor Nature. Jul, 2013 | Pubmed ID: 23863937 Integrated Nonlinear Optical Imaging Microscope for On-axis Crystal Detection and Centering at a Synchrotron Beamline Journal of Synchrotron Radiation. Jul, 2013 | Pubmed ID: 23765294 Hydrogen Bonding of Cholesterol in the Lipidic Cubic Phase Langmuir : the ACS Journal of Surfaces and Colloids. Jun, 2013 | Pubmed ID: 23763339 Structure of the Human Smoothened Receptor Bound to an Antitumour Agent Nature. May, 2013 | Pubmed ID: 23636324 Towards Protein-crystal Centering Using Second-harmonic Generation (SHG) Microscopy Acta Crystallographica. Section D, Biological Crystallography. May, 2013 | Pubmed ID: 23633594 Structural Features for Functional Selectivity at Serotonin Receptors Science (New York, N.Y.). May, 2013 | Pubmed ID: 23519215 Structural Basis for Molecular Recognition at Serotonin Receptors Science (New York, N.Y.). May, 2013 | Pubmed ID: 23519210 The GPCR Network: a Large-scale Collaboration to Determine Human GPCR Structure and Function Nature Reviews. Drug Discovery. Jan, 2013 | Pubmed ID: 23237917 Structure-function of the G Protein-coupled Receptor Superfamily Annual Review of Pharmacology and Toxicology. 2013 | Pubmed ID: 23140243 電圧ゲート K + チャネル孔モジュール、終了状態の脂質膜の結晶構造。 The Journal of Biological Chemistry. Dec, 2012 | Pubmed ID: 23095758 Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions Science (New York, N.Y.). Jul, 2012 | Pubmed ID: 22798613 Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-coupled Receptors Structure (London, England : 1993). Jun, 2012 | Pubmed ID: 22681902 Crystal Structures of the Outer Membrane Domain of Intimin and Invasin from Enterohemorrhagic E. Coli and Enteropathogenic Y. Pseudotuberculosis Structure (London, England : 1993). Jul, 2012 | Pubmed ID: 22658748 Structure of the Nociceptin/orphanin FQ Receptor in Complex with a Peptide Mimetic Nature. 2012 | Pubmed ID: 22596163 Structure of the Human κ-opioid Receptor in Complex with JDTic Nature. May, 2012 | Pubmed ID: 22437504 Gタンパク質共役型受容体構造の多様性とモジュール性 Trends in Pharmacological Sciences. Jan, 2012 | Pubmed ID: 22032986 混合ステロール洗剤ミセルのBicelleのようなアーキテクチャを使用したGPCRの安定化 Methods (San Diego, Calif.). Dec, 2011 | Pubmed ID: 22041719 ハイスループットX線小角散乱法による膜タンパク質の結晶化のための脂質マトリックスのキャラクタリゼーション Methods (San Diego, Calif.). Dec, 2011 | Pubmed ID: 21903166 脂質環境における高度好熱菌からBA3シトクロムc酸化酵素の高分解能構造 PloS One. 2011 | Pubmed ID: 21814577 膜タンパク質構造研究のための脂質キュービック相·テクノロジーズ Current Opinion in Structural Biology. Aug, 2011 | Pubmed ID: 21775127 ドキセピンによるヒトヒスタミンH1受容体複合体の構造 Nature. Jul, 2011 | Pubmed ID: 21697825 脂質中間相の膜タンパク質の結晶化を誘導するために自動化されたハイスループットLCP-FRAPアッセイの開発 Crystal Growth & Design. Apr, 2011 | Pubmed ID: 21660116 アゴニスト結合したヒトA2Aアデノシン受容体の構造 Science (New York, N.Y.). Apr, 2011 | Pubmed ID: 21393508 D2/D3選択的拮抗薬との複合体ヒトドーパミンD3受容体の構造 Science (New York, N.Y.). Nov, 2010 | Pubmed ID: 21097933 小分子と環状ペプチドアンタゴニストとCXCR4ケモカインGPCRの構造 Science (New York, N.Y.). Nov, 2010 | Pubmed ID: 20929726 X線結晶構造解析によって明らかにされた人間のベータ2アドレナリン受容体インバースアゴニストおよびアンタゴニストの保存バインディング·モード Journal of the American Chemical Society. Aug, 2010 | Pubmed ID: 20669948 GPCRの構造決定における最近の進歩、医薬品ターゲットとしての可能性が高い膜タンパク質ファミリー Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20665265 LCP-TM:膜環境での膜タンパク質の安定性を測定し、理解するためのアッセイ Biophysical Journal. Apr, 2010 | Pubmed ID: 20409473 脂質中間相における内在性膜タンパク質結晶の非線形光学イメージング Analytical Chemistry. Jan, 2010 | Pubmed ID: 20025250 サブ-10マイクロモルのサイズのX線放射光ビームによるヒト膜タンパク質の微結晶サンプルのスクリーニングとセンタリングのためのラスタ戦略 Journal of the Royal Society, Interface / the Royal Society. Oct, 2009 | Pubmed ID: 19535414 脂質中間相を用いた結晶膜タンパク質 Nature Protocols. 2009 | Pubmed ID: 19390528 β2-アドレナリン受容体に結合する完全と部分アゴニストの分析では、アゴニスト特有のコンフォメーション変化における膜貫通ヘリックスVの役割を示唆する Journal of Molecular Recognition : JMR. Jul-Aug, 2009 | Pubmed ID: 19353579 メソ結晶での事前スクリーニング膜タンパク質のLCP-FRAPアッセイ Crystal Growth & Design. 2008 | Pubmed ID: 19234616 アンタゴニストに結合したヒトA2Aアデノシン受容体の2.6オングストロームの結晶構造 Science (New York, N.Y.). Nov, 2008 | Pubmed ID: 18832607 Thermus Thermophilus由来の推定亜鉛トランスポーターCzrBの作用機序についての洞察 Structure (London, England : 1993). Sep, 2008 | Pubmed ID: 18786400 特定のコレステロール結合部位はヒトβ2-アドレナリン受容体2.8構造によって確立され Structure (London, England : 1993). Jun, 2008 | Pubmed ID: 18547522 メソ結晶構造とのドッキングシミュレーションでOPCA外膜アドヘシンの代替プロテオグリカン結合部位を提示 Proteins. Apr, 2008 | Pubmed ID: 18076035 エンジニアヒトβ2-アドレナリン作動性Gタンパク質共役型受容体の高分解能結晶構造 Science (New York, N.Y.). Nov, 2007 | Pubmed ID: 17962520 GPCRエンジニアリングは、β2-アドレナリン受容体機能に高解像度の構造的知見が得られ Science (New York, N.Y.). Nov, 2007 | Pubmed ID: 17962519 脂質中間相の膜タンパク質の結晶化。 X線Microdiffractionを使用した機構の研究 Faraday Discussions. 2007 | Pubmed ID: 17955811 結晶化と予備的 X 線回折分析サーマスから推定される亜鉛トランスポーター CzrB の水溶性ドメインの。 Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Aug, 2007 | Pubmed ID: 17671365 リン脂質のナノコーティングによる金属マイクロ流路を通る光の通過を制御する The Journal of Physical Chemistry. B. Nov, 2006 | Pubmed ID: 17064131 不飽和ホスファチジルエタノールアミン中のコレステロールの分子機構:X線回折及び固体2H NMRは、ホスファチジルコリンとの相違点を明らかに Journal of the American Chemical Society. Apr, 2006 | Pubmed ID: 16620109 移動するお部屋:腫れ脂質中間相の結晶化膜タンパク質 Journal of Molecular Biology. Apr, 2006 | Pubmed ID: 16490208 テーラード二重層の脂質中間相における膜タンパク質の結晶化 Structure (London, England : 1993). Dec, 2004 | Pubmed ID: 15576026 カオス脂質とコレステロールをCorralling障害からの注文。膜ラフト形成における多価不飽和脂質の役割 Chemistry and Physics of Lipids. Nov, 2004 | Pubmed ID: 15530450 膜タンパク質の結晶化のための脂質の合理的な設計 Journal of Structural Biology. Nov, 2004 | Pubmed ID: 15477097 脂質中間相の結晶化膜および可溶性タンパク質のロボットシステム Acta Crystallographica. Section D, Biological Crystallography. Oct, 2004 | Pubmed ID: 15388926 ドコサヘキサエン酸含有ホスファチジルを持つコレステロールとの相互作用:ミクロドメイン/ラフト形成のためのトリガー? Biochemistry. Oct, 2003 | Pubmed ID: 14556634 メソの膜タンパク質の結晶化:キュービック相の脂質タイプ仕立て Biophysical Journal. Dec, 2002 | Pubmed ID: 12496106 ハンドルには暑すぎ?脂質膜と中間相の放射光X線のダメージ Journal of Synchrotron Radiation. Nov, 2002 | Pubmed ID: 12409619 膜コレステロール含量を制御する。多価不飽和(docosahexaenoate)リン脂質の役割 Biochemistry. Oct, 2002 | Pubmed ID: 12369842 DIC(14)-amidine/DNA複合体の生物物理学的およびトランスフェクションの研究 Biophysical Journal. Jun, 2002 | Pubmed ID: 12023234 多価不飽和膜中のコレステロールの分子機構:ミクロドメイン形成 Biophysical Journal. Jan, 2002 | Pubmed ID: 11751316 準備とシリアルフェムト秒結晶学のための脂質立方相におけるタンパク質微結晶の配達 Andrii Ishchenko1,2, Vadim Cherezov1,2, Wei Liu3 1The Bridge Institute, University of Southern California, 2Department of Chemistry, University of Southern California, 3School of Molecular Sciences, Center for Applied Structural Discovery at the Biodesign Institute, Arizona State University Biochemistry 脂質中間相における膜タンパク質の結晶化 Wei Liu1, Vadim Cherezov1 1Molecular Biology, The Scripps Research Institute JoVE 2501 Biology
準備とシリアルフェムト秒結晶学のための脂質立方相におけるタンパク質微結晶の配達 Andrii Ishchenko1,2, Vadim Cherezov1,2, Wei Liu3 1The Bridge Institute, University of Southern California, 2Department of Chemistry, University of Southern California, 3School of Molecular Sciences, Center for Applied Structural Discovery at the Biodesign Institute, Arizona State University Biochemistry
脂質中間相における膜タンパク質の結晶化 Wei Liu1, Vadim Cherezov1 1Molecular Biology, The Scripps Research Institute JoVE 2501 Biology