Valentina Gandin

Lady Davis Institute and Department of Oncology, McGill University

Research Area

Biography

Valentina Gandin has not added Biography.
If you are Valentina Gandin and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 216	2014

Other Publications

Article	Year
Chemistry and biological activity of platinum amidine complexes. ChemMedChem\| PubMed ID: 21630470	2011
Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15961545	2005
GABP complex regulates transcription of eIF6 (p27BBP), an essential trans-acting factor in ribosome biogenesis. FEBS letters\| PubMed ID: 16530192	2006
Synthesis, characterization, and in vitro antitumor properties of tris(hydroxymethyl)phosphine copper(I) complexes containing the new bis(1,2,4-triazol-1-yl)acetate ligand. Journal of medicinal chemistry\| PubMed ID: 17149861	2006
Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells. Free radical biology & medicine\| PubMed ID: 17320769	2007
Cisplatinum and transplatinum complexes with benzyliminoether ligands; synthesis, characterization, structure-activity relationships, and in vitro and in vivo antitumor efficacy. Journal of medicinal chemistry\| PubMed ID: 17713897	2007
In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand. Journal of medicinal chemistry\| PubMed ID: 18251492	2008
Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation. Nature\| PubMed ID: 18784653	2008
Effects of the antioxidant Pycnogenol on cellular redox systems in U1285 human lung carcinoma cells. The FEBS journal\| PubMed ID: 19077163	2009
DNA binding ellipticine analogues: synthesis, biological evaluation, and structure-activity relationships. ChemMedChem\| PubMed ID: 19197924	2009
Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift. Free radical biology & medicine\| PubMed ID: 19486940	2009
Cytotoxicity of cis-platinum(II) cycloaliphatic amidine complexes: Ring size and solvent effects on the biological activity. Journal of inorganic biochemistry\| PubMed ID: 19560209	2009
Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase. Biochemical pharmacology\| PubMed ID: 19665452	2010
Synthesis and structural characterization of copper(I) complexes bearing N-methyl-1,3,5-triaza-7-phosphaadamantane (mPTA): cytotoxic activity evaluation of a series of water soluble Cu(I) de... Journal of inorganic biochemistry\| PubMed ID: 19822369	2009
Synthesis, characterization, and cytotoxicity of dinuclear platinum-bisphosphonate complexes to be used as prodrugs in the local treatment of bone tumours. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 20023921	2009
JNK inhibition arrests cotranslational degradation. Biochimica et biophysica acta\| PubMed ID: 20359507	2010
The relationship between the electrospray ionization behaviour and biological activity of some phosphino Cu(I) complexes. Rapid communications in mass spectrometry : RCM\| PubMed ID: 20486256	2010
S6K1 plays a critical role in early adipocyte differentiation. Developmental cell\| PubMed ID: 20493810	2010
Cytotoxicity in human cancer cells and mitochondrial dysfunction induced by a series of new copper(I) complexes containing tris(2-cyanoethyl)phosphines. Investigational new drugs\| PubMed ID: 20567997	2011
A new class of antitumor trans-amine-amidine-Pt(II) cationic complexes: influence of chemical structure and solvent on in vitro and in vivo tumor cell proliferation. Journal of medicinal chemistry\| PubMed ID: 20681543	2010
In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands. Journal of inorganic biochemistry\| PubMed ID: 21194623	2011
A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signalling. Journal of cellular and molecular medicine\| PubMed ID: 21388518	2012
Interaction of selenite and tellurite with thiol-dependent redox enzymes: Kinetics and mitochondrial implications. Free radical biology & medicine\| PubMed ID: 21397686	2011
Psoralenquinones as a novel class of proteasome inhibitors: design, synthesis and biological evaluation. ChemMedChem\| PubMed ID: 21472862	2011
Synthesis, characterization and cytotoxic properties of platinum(II) complexes containing the nucleosides adenosine and cytidine. Journal of inorganic biochemistry\| PubMed ID: 21514543	2011
Nitroimidazole and glucosamine conjugated heteroscorpionate ligands and related copper(II) complexes. Syntheses, biological activity and XAS studies. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 21709917	2011
Photoreactivity of 5-fluorouracil under UVB light: photolysis and cytotoxicity studies. Chemical research in toxicology\| PubMed ID: 21728355	2011
Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression. Journal of cellular and molecular medicine\| PubMed ID: 22003958	2012
Nanocrystalline carbonate-apatites: role of Ca/P ratio on the upload and release of anticancer platinum bisphosphonates. Nanoscale\| PubMed ID: 22075933	2012
Synthesis and characterization of azolate gold(I) phosphane complexes as thioredoxin reductase inhibiting antitumor agents. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 22391922	2012
Revisiting [PtCl₂(cis-1,4-DACH)]: an underestimated antitumor drug with potential application to the treatment of oxaliplatin-refractory colorectal cancer. Journal of medicinal chemistry\| PubMed ID: 22788918	2012
Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila. Development (Cambridge, England)\| PubMed ID: 22833128	2012
Synthesis and biological activity of ester- and amide-functionalized imidazolium salts and related water-soluble coinage metal N-heterocyclic carbene complexes. Inorganic chemistry\| PubMed ID: 22946642	2012
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies. Cancer research\| PubMed ID: 23100465	2012
Methylselenol formed by spontaneous methylation of selenide is a superior selenium substrate to the thioredoxin and glutaredoxin systems. PloS one\| PubMed ID: 23226364	2012
Neutral and charged phosphine/scorpionate copper(I) complexes: effects of ligand assembly on their antiproliferative activity. European journal of medicinal chemistry\| PubMed ID: 23229057	2013
(99m)Tc(N)-DBODC(5), a potential radiolabeled probe for SPECT of multidrug resistance: in vitro study. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry\| PubMed ID: 23543234	2013
Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex. Molecular and cellular biology\| PubMed ID: 23608534	2013
Novel imino thioether complexes of platinum(II): synthesis, structural investigation, and biological activity. Inorganic chemistry\| PubMed ID: 23647564	2013
Distinct translational control in CD4+ T cell subsets. PLoS genetics\| PubMed ID: 23658533	2013
Cell biology. Trans-HSF1 express. Science (New York, N.Y.)\| PubMed ID: 23869008	2013
Novel mixed-ligand copper(I) complexes: role of diimine ligands on cytotoxicity and genotoxicity. Journal of medicinal chemistry\| PubMed ID: 23964823	2013
Advances in copper complexes as anticancer agents. Chemical reviews\| PubMed ID: 24102434	2014
Synthesis and in vitro antitumor activity of water soluble sulfonate- and ester-functionalized silver(I) N-heterocyclic carbene complexes. Journal of inorganic biochemistry\| PubMed ID: 24121303	2013
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell metabolism\| PubMed ID: 24206664	2013
RACK1 Function in Cell Motility and Protein Synthesis. Genes & cancer\| PubMed ID: 24349634	2013
Selenium induces a multi-targeted cell death process in addition to ROS formation. Journal of cellular and molecular medicine\| PubMed ID: 24400844	2014
Inactive C-terminal telomerase reverse transcriptase insertion splicing variants are dominant-negative inhibitors of telomerase. Biochimie\| PubMed ID: 24412622	2014
Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. Journal of molecular cell biology\| PubMed ID: 24627160	2014
Largen: a molecular regulator of mammalian cell size control. Molecular cell\| PubMed ID: 24656129	2014
trans,cis,cis-Bis(benzoato)dichlorido(cyclohexane-1R,2R-diamine)platinum(IV): a Prodrug Candidate for the Treatment of Oxaliplatin-Refractory Colorectal Cancer. ChemMedChem\| PubMed ID: 24715720	2014
Role of zinc trafficking in male fertility: from germ to sperm. Human reproduction (Oxford, England)\| PubMed ID: 24771000	2014
In vitro and in vivo anticancer activity of copper(I) complexes with homoscorpionate tridentate tris(pyrazolyl)borate and auxilliary monodentate phosphine ligands. Journal of medicinal chemistry\| PubMed ID: 24793739	2014
Monofunctional Platinum(II) Complexes with Potent Tumor Cell Growth Inhibitory Activity: The Effect of a Hydrogen-Bond Donor/Acceptor N-Heterocyclic Ligand. ChemMedChem\| PubMed ID: 24799414	2014