Victor M. Darley-Usmar

Department of Pathology, University of Alabama at Birmingham - UAB

Affiliated withUniversity of Alabama at Birmingham - UAB University of Alabama at Birmingham

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 190	2010
Publication title Cited by 74	2014

Other Publications

Article	Year
Induction of glutathione synthesis by oxidized low-density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: protection against quinone-mediated oxidative stress. The Biochemical journal\| PubMed ID: 11829739	2002
Hypothesis: the mitochondrial NO(*) signaling pathway, and the transduction of nitrosative to oxidative cell signals: an alternative function for cytochrome C oxidase. Free radical biology & medicine\| PubMed ID: 11841927	2002
Activation of c-Jun N-terminal kinase and apoptosis in endothelial cells mediated by endogenous generation of hydrogen peroxide. Biological chemistry\| PubMed ID: 12033458	2002
High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes. Proteomics\| PubMed ID: 12203892	2002
Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species. Free radical biology & medicine\| PubMed ID: 12208364	2002
Obesity, aerobic exercise, and vascular disease: the role of oxidant stress. Obesity research\| PubMed ID: 12226146	2002
Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species. Trends in biochemical sciences\| PubMed ID: 12368076	2002
Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxide. Methods in enzymology\| PubMed ID: 12481582	2002
S-nitrosothiols inhibit uterine smooth muscle cell proliferation independent of metabolism to NO and cGMP formation. American journal of physiology. Cell physiology\| PubMed ID: 12584112	2003
Reversible inhibition of cytochrome c oxidase by peroxynitrite proceeds through ascorbate-dependent generation of nitric oxide. The Journal of biological chemistry\| PubMed ID: 12743113	2003
Cytoprotection against oxidative stress and the regulation of glutathione synthesis. Biological chemistry\| PubMed ID: 12751783	2003
Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide. Hepatology (Baltimore, Md.)\| PubMed ID: 12829996	2003
Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12881207	2003
Mass spectrometric methods for the analysis of chlorinated and nitrated isoflavonoids: a novel class of biological metabolites. Journal of mass spectrometry : JMS\| PubMed ID: 12898656	2003
Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12933349	2004
Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products. The Biochemical journal\| PubMed ID: 14616092	2004
Neutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant properties. Free radical biology & medicine\| PubMed ID: 14642389	2003
Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: role of mitochondrial respiratory complexes and heat shock proteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14691259	2004
Control of the nitric oxide-cytochrome c oxidase signaling pathway under pathological and physiological conditions. IUBMB life\| PubMed ID: 14711003	2003
Mechanisms of the interaction of nitroxyl with mitochondria. The Biochemical journal\| PubMed ID: 14723605	2004
L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemia. FEBS letters\| PubMed ID: 15013757	2004
Weight loss and race modulate nitric oxide metabolism in overweight women. Free radical biology & medicine\| PubMed ID: 15288126	2004
The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in mice. Hepatology (Baltimore, Md.)\| PubMed ID: 15349894	2004
Human glutamate cysteine ligase gene regulation through the electrophile response element. Free radical biology & medicine\| PubMed ID: 15451055	2004
Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway. Free radical biology & medicine\| PubMed ID: 15629859	2005
Redox signalling: from nitric oxide to oxidized lipids. Biochemical Society symposium\| PubMed ID: 15777016	2004
Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15805232	2005
Nitric oxide signaling gone awry: nitration of glutamine synthetase and hyperammonemia in sepsis. Hepatology (Baltimore, Md.)\| PubMed ID: 15841446	2005
Polarographic measurement of hydrogen sulfide production and consumption by mammalian tissues. Analytical biochemistry\| PubMed ID: 15866526	2005
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. Blood\| PubMed ID: 16195332	2006
Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria. The Biochemical journal\| PubMed ID: 16268779	2006
Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 16387790	2006
Metabolism of phytoestrogen conjugates. Methods in enzymology\| PubMed ID: 16399358	2005
A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stress. Free radical biology & medicine\| PubMed ID: 16443161	2006
Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells. The American journal of pathology\| PubMed ID: 16651638	2006
Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells. Circulation research\| PubMed ID: 17068300	2006
Hydrogen sulfide mediates vasoactivity in an O2-dependent manner. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17237242	2007
Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration. Circulation research\| PubMed ID: 17293481	2007
Methods for measuring the regulation of respiration by nitric oxide. Methods in cell biology\| PubMed ID: 17445706	2007
Is the soluble guanylate cyclase pathway the only one available for nitric oxide (NO) signaling? IUBMB life\| PubMed ID: 17454303	2007
Mechanism by which alcohol and wine polyphenols affect coronary heart disease risk. Annals of epidemiology\| PubMed ID: 17478321	2007
Evidence for oxygen as the master regulator of the responsiveness of soluble guanylate cyclase and cytochrome c oxidase to nitric oxide. The Biochemical journal\| PubMed ID: 17590153	2007
Hydrogen sulfide mediates the vasoactivity of garlic. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17951430	2007
Proteomic approaches to identify and characterize alterations to the mitochondrial proteome in alcoholic liver disease. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18369930	2008
Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling. The Journal of biological chemistry\| PubMed ID: 18378684	2008
S-nitrosation and thiol switching in the mitochondrion: a new paradigm for cardioprotection in ischaemic preconditioning. The Biochemical journal\| PubMed ID: 18466111	2008
High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo. The Biochemical journal\| PubMed ID: 18752470	2009
Methods for imaging and detecting modification of proteins by reactive lipid species. Free radical biology & medicine\| PubMed ID: 19446632	2009
Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal. The Biochemical journal\| PubMed ID: 19740075	2009
Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms. The Biochemical journal\| PubMed ID: 19916962	2010
Regulation of vascular smooth muscle cell bioenergetic function by protein glutathiolation. Biochimica et biophysica acta\| PubMed ID: 19925774	2010
Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species. Free radical biology & medicine\| PubMed ID: 20093177	2010
Role of cellular bioenergetics in smooth muscle cell proliferation induced by platelet-derived growth factor. The Biochemical journal\| PubMed ID: 20331438	2010
What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology. The Journal of biological chemistry\| PubMed ID: 20410298	2010
Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain. The Journal of biological chemistry\| PubMed ID: 20870728	2010
Bioenergetic function in cardiovascular cells: the importance of the reserve capacity and its biological regulation. Chemico-biological interactions\| PubMed ID: 21147079	2011
Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis. Traffic (Copenhagen, Denmark)\| PubMed ID: 21438970	2011
PYK2 信号时需要依赖于血小板衍生生长因子的血管平滑肌&... American journal of physiology. Cell physiology\| PubMed ID: 21451101	2011
Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis. Hepatology (Baltimore, Md.)\| PubMed ID: 21520201	2011
Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 21685262	2011
Assessing bioenergetic function in response to oxidative stress by metabolic profiling. Free radical biology & medicine\| PubMed ID: 21872656	2011
Protein O-linked Î²-N-acetylglucosamine: A novel effector of cardiomyocyte metabolism and function. Journal of molecular and cellular cardiology\| PubMed ID: 21878340	2011
Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress. Free radical biology & medicine\| PubMed ID: 21945098	2011
Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes. Biochimica et biophysica acta\| PubMed ID: 21971515	2011
Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: The protective role of autophagy. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 22245770	2012
The electrophile responsive proteome: integrating proteomics and lipidomics with cellular function. Antioxidants & redox signaling\| PubMed ID: 22352679	2012
Cell signalling by reactive lipid species: new concepts and molecular mechanisms. The Biochemical journal\| PubMed ID: 22364280	2012
Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation products. Free radical biology & medicine\| PubMed ID: 22954622	2013
Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death. PloS one\| PubMed ID: 22970265	2012
Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biological chemistry\| PubMed ID: 23092819	2012
Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 23528848	2013
Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita(+/Ins2)-derived β-cells. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 23820623	2013
Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload. The Biochemical journal\| PubMed ID: 23924350	2013
Quercetin prevents left ventricular hypertrophy in the Apo E knockout mouse. Redox biology\| PubMed ID: 24024175	2013
Lipid metabolites enhance secretion acting on SNARE microdomains and altering the extent and kinetics of single release events in bovine adrenal chromaffin cells. PloS one\| PubMed ID: 24073281	2013
Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells. Autophagy\| PubMed ID: 24145463	2013
A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers. Redox biology\| PubMed ID: 24494194	2014