William P. Schiemann Case Comprehensive Cancer Center Case Western Reserve University Biography Publications Institution JoVE Articles William P. Schiemann has not added a biography. If you are William P. Schiemann and would like to personalize this page please email our Author Liaison for assistance. Publications Deconstructing the Mechanisms and Consequences of TGF-β-induced EMT During Cancer Progression Cell and Tissue Research. Jan, 2012 | Pubmed ID: 21691718 Role of TGF-β and the Tumor Microenvironment During Mammary Tumorigenesis Gene Expression. 2011 | Pubmed ID: 22268294 NetSlim: High-confidence Curated Signaling Maps Database : the Journal of Biological Databases and Curation. 2011 | Pubmed ID: 21959865 β3 Integrin-EGF Receptor Cross-talk Activates P190RhoGAP in Mouse Mammary Gland Epithelial Cells Molecular Biology of the Cell. Nov, 2011 | Pubmed ID: 21937717 Krüppel-like Factor 4 Inhibits Tumorigenic Progression and Metastasis in a Mouse Model of Breast Cancer Neoplasia (New York, N.Y.). Jul, 2011 | Pubmed ID: 21750654 Down-regulation of Epithelial Cadherin is Required to Initiate Metastatic Outgrowth of Breast Cancer Molecular Biology of the Cell. Jul, 2011 | Pubmed ID: 21613543 Lysyl Oxidase Contributes to Mechanotransduction-mediated Regulation of Transforming Growth Factor-β Signaling in Breast Cancer Cells Neoplasia (New York, N.Y.). May, 2011 | Pubmed ID: 21532881 Noncanonical TGF-β Signaling During Mammary Tumorigenesis Journal of Mammary Gland Biology and Neoplasia. Jun, 2011 | Pubmed ID: 21448580 Fibromodulin Suppresses Nuclear Factor-kappaB Activity by Inducing the Delayed Degradation of IKBA Via a JNK-dependent Pathway Coupled to Fibroblast Apoptosis The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21156791 The Cain and Abl of Epithelial-mesenchymal Transition and Transforming Growth Factor-β in Mammary Epithelial Cells Cells, Tissues, Organs. 2011 | Pubmed ID: 21051857 Transforming Growth Factor-β and the Hallmarks of Cancer Cellular Signalling. Jun, 2011 | Pubmed ID: 20940046 Colorectal Cancer in the Cotton Top Tamarin (Saguinus Oedipus): How Do They Evade Liver Metastasis? Digestive Diseases and Sciences. Feb, 2011 | Pubmed ID: 20645001 Homeoprotein Six1 Increases TGF-beta Type I Receptor and Converts TGF-beta Signaling from Suppressive to Supportive for Tumor Growth Cancer Research. Dec, 2010 | Pubmed ID: 21056993 The Pathophysiology of Epithelial-mesenchymal Transition Induced by Transforming Growth Factor-beta in Normal and Malignant Mammary Epithelial Cells Journal of Mammary Gland Biology and Neoplasia. Jun, 2010 | Pubmed ID: 20467795 Repo-man Controls a Protein Phosphatase 1-dependent Threshold for DNA Damage Checkpoint Activation Current Biology : CB. Mar, 2010 | Pubmed ID: 20188555 PGE2 Receptor EP2 Mediates the Antagonistic Effect of COX-2 on TGF-beta Signaling During Mammary Tumorigenesis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2010 | Pubmed ID: 19897661 Mechanisms of the Epithelial-mesenchymal Transition by TGF-beta Future Oncology (London, England). Oct, 2009 | Pubmed ID: 19852727 Epithelial-mesenchymal Transition in Tumor Metastasis: a Method to the Madness Future Oncology (London, England). Oct, 2009 | Pubmed ID: 19852724 P130Cas is Required for Mammary Tumor Growth and Transforming Growth Factor-beta-mediated Metastasis Through Regulation of Smad2/3 Activity The Journal of Biological Chemistry. Dec, 2009 | Pubmed ID: 19822523 Therapeutic Targeting of the Focal Adhesion Complex Prevents Oncogenic TGF-beta Signaling and Metastasis Breast Cancer Research : BCR. 2009 | Pubmed ID: 19740433 The Six1 Homeoprotein Induces Human Mammary Carcinoma Cells to Undergo Epithelial-mesenchymal Transition and Metastasis in Mice Through Increasing TGF-beta Signaling The Journal of Clinical Investigation. Sep, 2009 | Pubmed ID: 19726885 Preclinical Efficacy of Cystatin C to Target the Oncogenic Activity of Transforming Growth Factor Beta in Breast Cancer Translational Oncology. Aug, 2009 | Pubmed ID: 19701502 Activated Abl Kinase Inhibits Oncogenic Transforming Growth Factor-beta Signaling and Tumorigenesis in Mammary Tumors FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2009 | Pubmed ID: 19690215 X-linked Inhibitor of Apoptosis Protein and Its E3 Ligase Activity Promote Transforming Growth Factor-{beta}-mediated Nuclear Factor-{kappa}B Activation During Breast Cancer Progression The Journal of Biological Chemistry. Aug, 2009 | Pubmed ID: 19531477 The TGF-beta Paradox in Human Cancer: an Update Future Oncology (London, England). Mar, 2009 | Pubmed ID: 19284383 Cox-2 Inactivates Smad Signaling and Enhances EMT Stimulated by TGF-beta Through a PGE2-dependent Mechanisms Carcinogenesis. Nov, 2008 | Pubmed ID: 18725385 Transcriptional and Translational Regulation of TGF-beta Production in Response to Apoptotic Cells Journal of Immunology (Baltimore, Md. : 1950). Sep, 2008 | Pubmed ID: 18714031 Fibulin-5 Initiates Epithelial-mesenchymal Transition (EMT) and Enhances EMT Induced by TGF-beta in Mammary Epithelial Cells Via a MMP-dependent Mechanism Carcinogenesis. Dec, 2008 | Pubmed ID: 18713838 Microfibril-associate Glycoprotein-2 (MAGP-2) Promotes Angiogenic Cell Sprouting by Blocking Notch Signaling in Endothelial Cells Microvascular Research. May, 2008 | Pubmed ID: 18417156 Altered TAB1:I KappaB Kinase Interaction Promotes Transforming Growth Factor Beta-mediated Nuclear Factor-kappaB Activation During Breast Cancer Progression Cancer Research. Mar, 2008 | Pubmed ID: 18316610 Grb2 Binding to Tyr284 in TbetaR-II is Essential for Mammary Tumor Growth and Metastasis Stimulated by TGF-beta Carcinogenesis. Feb, 2008 | Pubmed ID: 18174260 Transcriptome Analysis of Endothelial Cell Gene Expression Induced by Growth on Matrigel Matrices: Identification and Characterization of MAGP-2 and Lumican As Novel Regulators of Angiogenesis Angiogenesis. 2007 | Pubmed ID: 17632767 Targeted TGF-beta Chemotherapies: Friend or Foe in Treating Human Malignancies? Expert Review of Anticancer Therapy. May, 2007 | Pubmed ID: 17492924 Src Phosphorylates Tyr284 in TGF-beta Type II Receptor and Regulates TGF-beta Stimulation of P38 MAPK During Breast Cancer Cell Proliferation and Invasion Cancer Research. Apr, 2007 | Pubmed ID: 17440088 Role of Transforming Growth Factor-beta in Cancer Progression Future Oncology (London, England). Dec, 2006 | Pubmed ID: 17155901 Apoptotic Cells, Through Transforming Growth Factor-beta, Coordinately Induce Anti-inflammatory and Suppress Pro-inflammatory Eicosanoid and NO Synthesis in Murine Macrophages The Journal of Biological Chemistry. Dec, 2006 | Pubmed ID: 17056601 Beta3 Integrin and Src Facilitate Transforming Growth Factor-beta Mediated Induction of Epithelial-mesenchymal Transition in Mammary Epithelial Cells Breast Cancer Research : BCR. 2006 | Pubmed ID: 16859511 TGF-beta in Cancer and Other Diseases Future Oncology (London, England). Apr, 2006 | Pubmed ID: 16563087 Fibulins 3 and 5 Antagonize Tumor Angiogenesis in Vivo Cancer Research. Mar, 2006 | Pubmed ID: 16510581 Fibulin-5 Function During Tumorigenesis Future Oncology (London, England). Feb, 2005 | Pubmed ID: 16555973 The Use of Cystatin C to Inhibit Epithelial-mesenchymal Transition and Morphological Transformation Stimulated by Transforming Growth Factor-beta Breast Cancer Research : BCR. 2005 | Pubmed ID: 16168131 Identification and Characterization of Regulator of G Protein Signaling 4 (RGS4) As a Novel Inhibitor of Tubulogenesis: RGS4 Inhibits Mitogen-activated Protein Kinases and Vascular Endothelial Growth Factor Signaling Molecular Biology of the Cell. Feb, 2005 | Pubmed ID: 15548600 Fibulin-2 and Fibulin-5 Alterations in Tsk Mice Associated with Disorganized Hypodermal Elastic Fibers and Skin Tethering The Journal of Investigative Dermatology. Dec, 2004 | Pubmed ID: 15610515 Fibulin-5 Promotes Wound Healing in Vivo Journal of the American College of Surgeons. Sep, 2004 | Pubmed ID: 15325610 Fibulin-5 Antagonizes Vascular Endothelial Growth Factor (VEGF) Signaling and Angiogenic Sprouting by Endothelial Cells DNA and Cell Biology. Jun, 2004 | Pubmed ID: 15231070 Pigment Epithelium-derived Factor in Idiopathic Pulmonary Fibrosis: a Role in Aberrant Angiogenesis American Journal of Respiratory and Critical Care Medicine. Aug, 2004 | Pubmed ID: 15117744 Transforming Growth Factor-beta (TGF-beta)-resistant B Cells from Chronic Lymphocytic Leukemia Patients Contain Recurrent Mutations in the Signal Sequence of the Type I TGF-beta Receptor Cancer Detection and Prevention. 2004 | Pubmed ID: 15041079 Cystatin C Antagonizes Transforming Growth Factor Beta Signaling in Normal and Cancer Cells Molecular Cancer Research : MCR. Mar, 2004 | Pubmed ID: 15037657 Cloning of a Novel Signaling Molecule, AMSH-2, That Potentiates Transforming Growth Factor Beta Signaling BMC Cell Biology. Jan, 2004 | Pubmed ID: 14728725 Development of Human Protein Reference Database As an Initial Platform for Approaching Systems Biology in Humans Genome Research. Oct, 2003 | Pubmed ID: 14525934 SPARC Inhibits Epithelial Cell Proliferation in Part Through Stimulation of the Transforming Growth Factor-beta-signaling System Molecular Biology of the Cell. Oct, 2003 | Pubmed ID: 14517312 Context-specific Effects of Fibulin-5 (DANCE/EVEC) on Cell Proliferation, Motility, and Invasion. Fibulin-5 is Induced by Transforming Growth Factor-beta and Affects Protein Kinase Cascades The Journal of Biological Chemistry. Jul, 2002 | Pubmed ID: 12021267 Cross-talk Between ERK and P38 MAPK Mediates Selective Suppression of Pro-inflammatory Cytokines by Transforming Growth Factor-beta The Journal of Biological Chemistry. Apr, 2002 | Pubmed ID: 11842088 In vivo dupla Substrato Bioluminescent imagem Michael K. Wendt1, Joseph Molter1, Christopher A. Flask1, William P. Schiemann1 1Case Comprehensive Cancer Center, Case Western Reserve University JoVE 3245 Medicine
In vivo dupla Substrato Bioluminescent imagem Michael K. Wendt1, Joseph Molter1, Christopher A. Flask1, William P. Schiemann1 1Case Comprehensive Cancer Center, Case Western Reserve University JoVE 3245 Medicine