William P. Schiemann

Case Comprehensive Cancer Center, Case Western Reserve University

Affiliated withCase Western Reserve University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 20	2011

Other Publications

Article	Year
Transcriptome analysis of endothelial cell gene expression induced by growth on matrigel matrices: identification and characterization of MAGP-2 and lumican as novel regulators of angiogenes... Angiogenesis\| PubMed ID: 17632767	2007
Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta. Carcinogenesis\| PubMed ID: 18174260	2008
Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta. The Journal of biological chemistry\| PubMed ID: 11842088	2002
Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. The Journal of biological chemistry\| PubMed ID: 12021267	2002
SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system. Molecular biology of the cell\| PubMed ID: 14517312	2003
Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome research\| PubMed ID: 14525934	2003
Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling. BMC cell biology\| PubMed ID: 14728725	2004
Cystatin C antagonizes transforming growth factor beta signaling in normal and cancer cells. Molecular cancer research : MCR\| PubMed ID: 15037657	2004
Transforming growth factor-beta (TGF-beta)-resistant B cells from chronic lymphocytic leukemia patients contain recurrent mutations in the signal sequence of the type I TGF-beta receptor. Cancer detection and prevention\| PubMed ID: 15041079	2004
Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis. American journal of respiratory and critical care medicine\| PubMed ID: 15117744	2004
Fibulin-5 antagonizes vascular endothelial growth factor (VEGF) signaling and angiogenic sprouting by endothelial cells. DNA and cell biology\| PubMed ID: 15231070	2004
Fibulin-5 promotes wound healing in vivo. Journal of the American College of Surgeons\| PubMed ID: 15325610	2004
Identification and characterization of regulator of G protein signaling 4 (RGS4) as a novel inhibitor of tubulogenesis: RGS4 inhibits mitogen-activated protein kinases and vascular endotheli... Molecular biology of the cell\| PubMed ID: 15548600	2005
Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering. The Journal of investigative dermatology\| PubMed ID: 15610515	2004
The use of cystatin C to inhibit epithelial-mesenchymal transition and morphological transformation stimulated by transforming growth factor-beta. Breast cancer research : BCR\| PubMed ID: 16168131	2005
Fibulins 3 and 5 antagonize tumor angiogenesis in vivo. Cancer research\| PubMed ID: 16510581	2006
Fibulin-5 function during tumorigenesis. Future oncology (London, England)\| PubMed ID: 16555973	2005
TGF-beta in cancer and other diseases. Future oncology (London, England)\| PubMed ID: 16563087	2006
Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells. Breast cancer research : BCR\| PubMed ID: 16859511	2006
Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages. The Journal of biological chemistry\| PubMed ID: 17056601	2006
Role of transforming growth factor-beta in cancer progression. Future oncology (London, England)\| PubMed ID: 17155901	2006
Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion. Cancer research\| PubMed ID: 17440088	2007
Targeted TGF-beta chemotherapies: friend or foe in treating human malignancies? Expert review of anticancer therapy\| PubMed ID: 17492924	2007
Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression. Cancer research\| PubMed ID: 18316610	2008
Microfibril-associate glycoprotein-2 (MAGP-2) promotes angiogenic cell sprouting by blocking notch signaling in endothelial cells. Microvascular research\| PubMed ID: 18417156	2008
Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism. Carcinogenesis\| PubMed ID: 18713838	2008
Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18714031	2008
Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms. Carcinogenesis\| PubMed ID: 18725385	2008
The TGF-beta paradox in human cancer: an update. Future oncology (London, England)\| PubMed ID: 19284383	2009
X-linked inhibitor of apoptosis protein and its E3 ligase activity promote transforming growth factor-{beta}-mediated nuclear factor-{kappa}B activation during breast cancer progression. The Journal of biological chemistry\| PubMed ID: 19531477	2009
Activated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumors. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 19690215	2009
Preclinical efficacy of cystatin C to target the oncogenic activity of transforming growth factor Beta in breast cancer. Translational oncology\| PubMed ID: 19701502	2009
The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. The Journal of clinical investigation\| PubMed ID: 19726885	2009
Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis. Breast cancer research : BCR\| PubMed ID: 19740433	2009
p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. The Journal of biological chemistry\| PubMed ID: 19822523	2009
Epithelial-mesenchymal transition in tumor metastasis: a method to the madness. Future oncology (London, England)\| PubMed ID: 19852724	2009
Mechanisms of the epithelial-mesenchymal transition by TGF-beta. Future oncology (London, England)\| PubMed ID: 19852727	2009
PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-beta signaling during mammary tumorigenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 19897661	2010
Repo-man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation. Current biology : CB\| PubMed ID: 20188555	2010
The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells. Journal of mammary gland biology and neoplasia\| PubMed ID: 20467795	2010
Colorectal cancer in the cotton top tamarin (Saguinus oedipus): how do they evade liver metastasis? Digestive diseases and sciences\| PubMed ID: 20645001	2011
Transforming growth factor-Î² and the hallmarks of cancer. Cellular signalling\| PubMed ID: 20940046	2011
The Cain and Abl of epithelial-mesenchymal transition and transforming growth factor-Î² in mammary epithelial cells. Cells, tissues, organs\| PubMed ID: 21051857	2011
Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth. Cancer research\| PubMed ID: 21056993	2010
Fibromodulin suppresses nuclear factor-kappaB activity by inducing the delayed degradation of IKBA via a JNK-dependent pathway coupled to fibroblast apoptosis. The Journal of biological chemistry\| PubMed ID: 21156791	2011
Noncanonical TGF-Î² signaling during mammary tumorigenesis. Journal of mammary gland biology and neoplasia\| PubMed ID: 21448580	2011
Lysyl oxidase contributes to mechanotransduction-mediated regulation of transforming growth factor-Î² signaling in breast cancer cells. Neoplasia (New York, N.Y.)\| PubMed ID: 21532881	2011
Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer. Molecular biology of the cell\| PubMed ID: 21613543	2011
Deconstructing the mechanisms and consequences of TGF-Î²-induced EMT during cancer progression. Cell and tissue research\| PubMed ID: 21691718	2012
KrÃ¼ppel-like factor 4 inhibits tumorigenic progression and metastasis in a mouse model of breast cancer. Neoplasia (New York, N.Y.)\| PubMed ID: 21750654	2011
Î²3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells. Molecular biology of the cell\| PubMed ID: 21937717	2011
NetSlim: high-confidence curated signaling maps. Database : the journal of biological databases and curation\| PubMed ID: 21959865	2011
Role of TGF-Î² and the tumor microenvironment during mammary tumorigenesis. Gene expression\| PubMed ID: 22268294	2011