William R. Jeffery

William R. Jeffery

Department of Biology, University of Maryland

Affiliated withUniversity of Maryland

Research Area

Biography

William R. Jeffery is Professor of Biology and Cell Biology and Molecular Genetics at the University of Maryland, College Park. He has also been the Johann Friedrich Miescher Regents Professor of Molecular Biology at the University of Texas at Austin, Professor of Molecular and Cellular Biology at the University of California, Davis, and Professor and Head of Biology at The Pennsylvania State University. Dr. Jeffery has published 235 papers on various topics in developmental and evolutionary biology and is particularly known for his studies on the localization of maternal determinants, including the discovery of the first localized mRNA, the role of regulatory genes in controlling changes in invertebrate larval types, and the evolutionary mechanisms of eye and pigment degeneration in cavefish. He has served on NSF and NIH panels, is a former member of the Council for the NIH Institute of Child Health and Human Development, and has served or is currently serving on the editorial boards of 10 journals. He is a former instructor and Director Emeritus in the Embryology Course, an advisor to the Grass Program in Neurobiology, and a member of the Bell Center for Regenerative Biology and Tissue Engineering at the Marine Biological Laboratory, Woods Hole. Dr. Jeffery has served as President of the Developmental Biology Section of the Society for Integrative Biology, the President of the Society for Developmental Biology, and is a Fellow of the American Association for the Advancement of Science. His awards include the 2010 medal for Research Excellence in Karst Science, the 2012 A. O. Kowalevsky International Medal in Comparative Developmental Biology, and the 2018 National Speleological Society Science Award.

JoVE Journal Publications

ArticleTotal : 2
Year
Genome Editing in <em>Astyanax mexicanus</em> Using Transcription Activator-like Effector Nucleases (TALENs)
Publication title

Cited by 21

2016
2021

Other Publications

Article
Year
Role of PCNA and ependymal cells in ascidian neural development.

Gene| PubMed ID: 11992727

2002
Retinal homeobox genes and the role of cell proliferation in cavefish eye degeneration.

The International journal of developmental biology| PubMed ID: 12068949

2002
2002
Ascidian gene-expression profiles.

Genome biology| PubMed ID: 12372151

2002
Probing teleost eye development by lens transplantation.

Methods (San Diego, Calif.)| PubMed ID: 12507460

2002
2003
2004
2004
2004
Blind cavefish and heat shock protein chaperones: a novel role for hsp90alpha in lens apoptosis.

The International journal of developmental biology| PubMed ID: 15558465

2004
2005
Zebrafish Hsp70 is required for embryonic lens formation.

Cell stress & chaperones| PubMed ID: 15832949

2005
2004
2006
Ascidian neural crest-like cells: phylogenetic distribution, relationship to larval complexity, and pigment cell fate.

Journal of experimental zoology. Part B, Molecular and developmental evolution| PubMed ID: 16619245

2006
Chordate ancestry of the neural crest: new insights from ascidians.

Seminars in cell & developmental biology| PubMed ID: 17509911

2007
2007
2007
2008
2008
2008
Synteny and candidate gene prediction using an anchored linkage map of Astyanax mexicanus.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 19104060

2008
2009
Chapter 8. Evolution and development in the cavefish Astyanax.

Current topics in developmental biology| PubMed ID: 19361694

2009
Regressive evolution in Astyanax cavefish.

Annual review of genetics| PubMed ID: 19640230

2009
2010
2010
2009
2011
To see or not to see: evolution of eye degeneration in mexican blind cavefish.

Integrative and comparative biology| PubMed ID: 21680461

2003
2012
2012
2012
2012
2012
2013
2013
Evolution and development in cave animals: from fish to crustaceans.

Wiley interdisciplinary reviews. Developmental biology| PubMed ID: 23580903

2012
2013
QTL clustering as a mechanism for rapid multi-trait evolution.

Communicative & integrative biology| PubMed ID: 23956812

2013
2013
Convergence in feeding posture occurs through different genetic loci in independently evolved cave populations of Astyanax mexicanus.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 24085851

2013
2014
2013
2013
2015
2014
The cavefish genome reveals candidate genes for eye loss.

Nature communications| PubMed ID: 25329095

2014
2015
2015
2015
2015
2014
2015
Regeneration, Stem Cells, and Aging in the Tunicate Ciona: Insights from the Oral Siphon.

International review of cell and molecular biology| PubMed ID: 26404471

2015
2015
2016
2017
2018
2018
An epigenetic mechanism for cavefish eye degeneration.

Nature ecology & evolution| PubMed ID: 29807993

2018
Maternal genetic effects in Astyanax cavefish development.

Developmental biology| PubMed ID: 30031754

2018
Seeing a bright future for a blind fish.

Developmental biology| PubMed ID: 30166000

2018
2019
2018
Dual roles of the retinal pigment epithelium and lens in cavefish eye degeneration.

Journal of experimental zoology. Part B, Molecular and developmental evolution| PubMed ID: 31930686

2020
2020
surface and cave fish morphs.

EvoDevo| PubMed ID: 32676179

2020
Fundamental research questions in subterranean biology.

Biological reviews of the Cambridge Philosophical Society| PubMed ID: 32841483

2020
2020