Xiaolei Xu Biography Publications JoVE Articles Xiaolei Xu has not added a biography. If you are Xiaolei Xu and would like to personalize this page please email our Author Liaison for assistance. Publications Allelic Heterogeneity of TTNtv Cardiomyopathy Can Be Modeled in Adult Zebrafish JCI Insight. Feb, 2024 | Pubmed ID: 38412038 Zbtb16 Increases Susceptibility of Atrial Fibrillation in Type 2 Diabetic Mice Via Txnip-Trx2 Signaling Cellular and Molecular Life Sciences : CMLS. Feb, 2024 | Pubmed ID: 38349408 Premature Senescence and Cardiovascular Disease Following Cancer Treatments: Mechanistic Insights Frontiers in Cardiovascular Medicine. 2023 | Pubmed ID: 37781317 Kidney Transcriptome and Cystic Kidney Disease Genes in Zebrafish Frontiers in Physiology. 2023 | Pubmed ID: 37256068 Molecular Mechanisms of Anthracycline Induced Cardiotoxicity: Zebrafish Come into Play Frontiers in Cardiovascular Medicine. 2023 | Pubmed ID: 36970353 Using Zebrafish Animal Model to Study the Genetic Underpinning and Mechanism of Arrhythmogenic Cardiomyopathy International Journal of Molecular Sciences. Feb, 2023 | Pubmed ID: 36835518 Transcriptome Studies of Inherited Dilated Cardiomyopathies Mammalian Genome : Official Journal of the International Mammalian Genome Society. Jun, 2023 | Pubmed ID: 36749382 Application of an F0-based Genetic Assay in Adult Zebrafish to Identify Modifier Genes of an Inherited Cardiomyopathy Disease Models & Mechanisms. May, 2023 | Pubmed ID: 35481478 Radiation Therapy Induces Immunosenescence Mediated by P90RSK Frontiers in Cardiovascular Medicine. 2022 | Pubmed ID: 36426217 Genetic Therapy in a Mitochondrial Disease Model Suggests a Critical Role for Liver Dysfunction in Mortality ELife. Nov, 2022 | Pubmed ID: 36408801 A Phenotype-based Forward Genetic Screen Identifies As a Sick Sinus Syndrome Gene ELife. Oct, 2022 | Pubmed ID: 36255053 A Missense Mutation in the Proprotein Convertase Gene Furinb Causes Hepatic Cystogenesis During Liver Development in Zebrafish Hepatology Communications. Nov, 2022 | Pubmed ID: 36017776 Genetic Susceptibility and Mechanisms Underlying the Pathogenesis of Anthracycline-Associated Cardiotoxicity Oxidative Medicine and Cellular Longevity. 2022 | Pubmed ID: 35965684 A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish Genes. Jul, 2022 | Pubmed ID: 35893052 Vascular Injury in the Zebrafish Tail Modulates Blood Flow and Peak Wall Shear Stress to Restore Embryonic Circular Network Frontiers in Cardiovascular Medicine. 2022 | Pubmed ID: 35369301 Corrigendum to 'Induction of Wnt Signaling Antagonists and P21-activated Kinase Enhances Cardiomyocyte Proliferation During Zebrafish Heart Regeneration' Journal of Molecular Cell Biology. Jan, 2022 | Pubmed ID: 35092682 A Novel Wireless ECG System for Prolonged Monitoring of Multiple Zebrafish for Heart Disease and Drug Screening Studies Biosensors & Bioelectronics. Feb, 2022 | Pubmed ID: 34801796 Inhibition of MTOR or MAPK Ameliorates Vmhcl/myh7 Cardiomyopathy in Zebrafish JCI Insight. Dec, 2021 | Pubmed ID: 34935644 Changes in Ion Channel Expression and Function Associated with Cardiac Arrhythmogenic Remodeling by Sorbs2 Biochimica Et Biophysica Acta. Molecular Basis of Disease. Dec, 2021 | Pubmed ID: 34487812 A Swimming-based Assay to Determine the Exercise Capacity of Adult Zebrafish Cardiomyopathy Models Bio-protocol. Aug, 2021 | Pubmed ID: 34458408 -Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity Circulation Research. Oct, 2021 | Pubmed ID: 34384247 Disruption of Gene Function Increases the Risk of Doxorubicin-Induced Cardiomyopathy and Heart Failure BioMed Research International. 2021 | Pubmed ID: 34327238 Deep Learning-based Framework for Cardiac Function Assessment in Embryonic Zebrafish from Heart Beating Videos Computers in Biology and Medicine. Aug, 2021 | Pubmed ID: 34157469 TFEB Overexpression, Not MTOR Inhibition, Ameliorates RagC Cardiomyopathy International Journal of Molecular Sciences. May, 2021 | Pubmed ID: 34071043 Induction of Wnt Signaling Antagonists and P21-activated Kinase Enhances Cardiomyocyte Proliferation During Zebrafish Heart Regeneration Journal of Molecular Cell Biology. Apr, 2021 | Pubmed ID: 33582796 Haploinsufficiency Ameliorates Renal Cysts and Cilia Abnormality in Adult Zebrafish Mutants Journal of the American Society of Nephrology : JASN. Apr, 2021 | Pubmed ID: 33574160 Modeling Inherited Cardiomyopathies in Adult Zebrafish for Precision Medicine Frontiers in Physiology. 2020 | Pubmed ID: 33329049 Continuous Electrocardiogram Monitoring in Zebrafish with Prolonged Mild Anesthesia Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. Jul, 2020 | Pubmed ID: 33018541 Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy Journal of the American Heart Association. Sep, 2020 | Pubmed ID: 32808564 Building the Vertebrate Codex Using the Gene Breaking Protein Trap Library ELife. 08, 2020 | Pubmed ID: 32779569 A Feasibility Study for Noninvasive Measurement of Shear Wave Speed in Live Zebrafish Ultrasonics. Sep, 2020 | Pubmed ID: 32417695 Aging-associated Sinus Arrest and Sick Sinus Syndrome in Adult Zebrafish PloS One. 2020 | Pubmed ID: 32401822 Retinoid X Receptor Alpha is a Spatiotemporally Predominant Therapeutic Target for Anthracycline-induced Cardiotoxicity Science Advances. Jan, 2020 | Pubmed ID: 32064346 Acquisition, Processing and Analysis of Electrocardiogram in Awake Zebrafish IEEE Sensors Journal. Jun, 2019 | Pubmed ID: 32855627 Haploinsufficiency of Mechanistic Target of Rapamycin Ameliorates Cardiomyopathy in Adult Zebrafish Disease Models & Mechanisms. Oct, 2019 | Pubmed ID: 31492659 Phenotyping an Adult Zebrafish Lamp2 Cardiomyopathy Model Identifies MTOR Inhibition As a Candidate Therapy Journal of Molecular and Cellular Cardiology. Aug, 2019 | Pubmed ID: 31228518 Displacement Analysis of Myocardial Mechanical Deformation (DIAMOND) Reveals Segmental Susceptibility to Doxorubicin-induced Injury and Regeneration JCI Insight. Apr, 2019 | Pubmed ID: 30996130 A Langendorff-like System to Quantify Cardiac Pump Function in Adult Zebrafish Disease Models & Mechanisms. Sep, 2018 | Pubmed ID: 30012855 Phenotyping Cardiomyopathy in Adult Zebrafish Progress in Biophysics and Molecular Biology. Oct, 2018 | Pubmed ID: 29884423 Real-Time Monitoring and Analysis of Zebrafish Electrocardiogram with Anomaly Detection Sensors (Basel, Switzerland). Dec, 2017 | Pubmed ID: 29283402 Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair Scientific Reports. Aug, 2017 | Pubmed ID: 28819303 Recessive TAF1A Mutations Reveal Ribosomopathy in Siblings with End-stage Pediatric Dilated Cardiomyopathy Human Molecular Genetics. Aug, 2017 | Pubmed ID: 28472305 Systematic Identification and Characterization of Cardiac Long Intergenic Noncoding RNAs in Zebrafish Scientific Reports. 04, 2017 | Pubmed ID: 28455512 Oxidative Stress-Induced Afterdepolarizations and Protein Kinase C Signaling International Journal of Molecular Sciences. Mar, 2017 | Pubmed ID: 28358314 Autophagy Activators Suppress Cystogenesis in an Autosomal Dominant Polycystic Kidney Disease Model Human Molecular Genetics. Jan, 2017 | Pubmed ID: 28007903 Modeling -Associated Dilated Cardiomyopathy in Adult Zebrafish Journal of Cardiovascular Development and Disease. Mar, 2016 | Pubmed ID: 28955713 Exon- and Contraction-dependent Functions of Titin in Sarcomere Assembly Development (Cambridge, England). Nov, 2016 | Pubmed ID: 27836965 A Modifier Screen Identifies As a Cardiomyopathy Susceptibility Gene JCI Insight. Sep, 2016 | Pubmed ID: 27642634 Effects of Ventricular Conduction Block Patterns on Mortality in Hospitalized Patients with Dilated Cardiomyopathy: a Single-center Cohort Study BMC Cardiovascular Disorders. Jun, 2016 | Pubmed ID: 27296108 De Novo RRAGC Mutation Activates MTORC1 Signaling in Syndromic Fetal Dilated Cardiomyopathy Human Genetics. Aug, 2016 | Pubmed ID: 27234373 Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function Scientific Reports. Mar, 2016 | Pubmed ID: 26935567 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition) Autophagy. Jan, 2016 | Pubmed ID: 26799652 Both Ciliary and Non-ciliary Functions of Foxj1a Confer Wnt/β-catenin Signaling in Zebrafish Left-right Patterning Biology Open. 2015 | Pubmed ID: 26432885 Cardiac Transcriptome and Dilated Cardiomyopathy Genes in Zebrafish Circulation. Cardiovascular Genetics. Apr, 2015 | Pubmed ID: 25583992 Understanding Cardiac Sarcomere Assembly with Zebrafish Genetics Anatomical Record (Hoboken, N.J. : 2007). Sep, 2014 | Pubmed ID: 25125181 Cardiac Troponin T (TNNT2) Mutations in Chinese Dilated Cardiomyopathy Patients BioMed Research International. 2014 | Pubmed ID: 25110706 Cessation of Contraction Induces Cardiomyocyte Remodeling During Zebrafish Cardiogenesis American Journal of Physiology. Heart and Circulatory Physiology. Feb, 2014 | Pubmed ID: 24322613 Anti-remodeling Effects of Rapamycin in Experimental Heart Failure: Dose Response and Interaction with Angiotensin Receptor Blockade PloS One. 2013 | Pubmed ID: 24312548 New and TALENted Genome Engineering Toolbox Circulation Research. Aug, 2013 | Pubmed ID: 23948583 Trapping Cardiac Recessive Mutants Via Expression-based Insertional Mutagenesis Screening Circulation Research. Feb, 2013 | Pubmed ID: 23283723 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy Autophagy. Apr, 2012 | Pubmed ID: 22966490 Target of Rapamycin (TOR)-based Therapy for Cardiomyopathy: Evidence from Zebrafish and Human Studies Trends in Cardiovascular Medicine. Feb, 2012 | Pubmed ID: 22841839 α-Actinin2 is Required for the Lateral Alignment of Z Discs and Ventricular Chamber Enlargement During Zebrafish Cardiogenesis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2012 | Pubmed ID: 22767232 Target of Rapamcyin (TOR)-based Therapeutics for Cardiomyopathy: Insights from Zebrafish Genetics Cell Cycle (Georgetown, Tex.). Feb, 2012 | Pubmed ID: 22262179 Quantifying Cardiac Functions in Embryonic and Adult Zebrafish Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22222517 Wnt/β-catenin Signaling Directly Regulates Foxj1 Expression and Ciliogenesis in Zebrafish Kupffer's Vesicle Development (Cambridge, England). Feb, 2012 | Pubmed ID: 22190638 TOR-autophagy Signaling in Adult Zebrafish Models of Cardiomyopathy Autophagy. Jan, 2012 | Pubmed ID: 22186229 Functions of the Wnt/β-catenin Pathway in an Anemia-induced Zebrafish Model of Cardiomyopathy Are Location Dependent Biochemical and Biophysical Research Communications. Nov, 2011 | Pubmed ID: 22056559 Haploinsufficiency of Target of Rapamycin Attenuates Cardiomyopathies in Adult Zebrafish Circulation Research. Sep, 2011 | Pubmed ID: 21757652 In Vivo Protein Trapping Produces a Functional Expression Codex of the Vertebrate Proteome Nature Methods. Jun, 2011 | Pubmed ID: 21552255 Iron-catalyzed, Microwave-promoted, One-pot Synthesis of 9-substituted Xanthenes by a Cascade Benzylation-cyclization Process Organic Letters. Jan, 2010 | Pubmed ID: 19938841 [Effect of Iron Deficiency on Vitamin A Metabolism in Rats] Wei Sheng Yan Jiu = Journal of Hygiene Research. Sep, 2009 | Pubmed ID: 19877508 Depletion of Zebrafish Tcap Leads to Muscular Dystrophy Via Disrupting Sarcomere-membrane Interaction, Not Sarcomere Assembly Human Molecular Genetics. Nov, 2009 | Pubmed ID: 19679566 Cardiac Hypertrophy Involves Both Myocyte Hypertrophy and Hyperplasia in Anemic Zebrafish PloS One. 2009 | Pubmed ID: 19672293 Myofibrillogenesis in the Developing Zebrafish Heart: A Functional Study of Tnnt2 Developmental Biology. Jul, 2009 | Pubmed ID: 19427304 Transient and Transgenic Analysis of the Zebrafish Ventricular Myosin Heavy Chain (vmhc) Promoter: an Inhibitory Mechanism of Ventricle-specific Gene Expression Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jun, 2009 | Pubmed ID: 19322764 Distinct Functions of Wnt/beta-catenin Signaling in KV Development and Cardiac Asymmetry Development (Cambridge, England). Jan, 2009 | Pubmed ID: 19103803 [Effect of Higher Iron in Diet on Iron Levels and Hepcidin MRNA Expression Levels in Rats] Wei Sheng Yan Jiu = Journal of Hygiene Research. Jul, 2008 | Pubmed ID: 18839536 Depletion of Zebrafish Essential and Regulatory Myosin Light Chains Reduces Cardiac Function Through Distinct Mechanisms Cardiovascular Research. Jul, 2008 | Pubmed ID: 18343897 Wnt3a Regulates the Development of Cardiac Neural Crest Cells by Modulating Expression of Cysteine-rich Intestinal Protein 2 in Rhombomere 6 Circulation Research. Apr, 2008 | Pubmed ID: 18292601 Neuropilin-1 Modulates P53/caspases Axis to Promote Endothelial Cell Survival PloS One. 2007 | Pubmed ID: 18000534 Depletion of Med10 Enhances Wnt and Suppresses Nodal Signaling During Zebrafish Embryogenesis Developmental Biology. Mar, 2007 | Pubmed ID: 17208216 Depletion of Zebrafish Titin Reduces Cardiac Contractility by Disrupting the Assembly of Z-discs and A-bands Circulation Research. Feb, 2007 | Pubmed ID: 17170364 C Terminus of RGS-GAIP-interacting Protein Conveys Neuropilin-1-mediated Signaling During Angiogenesis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2006 | Pubmed ID: 16754745 Genotype-phenotype Relationships Involving Hypertrophic Cardiomyopathy-associated Mutations in Titin, Muscle LIM Protein, and Telethonin Molecular Genetics and Metabolism. May, 2006 | Pubmed ID: 16352453 Different Biological Effects of Unmodified Prolactin and a Molecular Mimic of Phosphorylated Prolactin Involve Different Signaling Pathways Biochemistry. Jun, 2003 | Pubmed ID: 12809512 Opposite Effects of Unmodified Prolactin and a Molecular Mimic of Phosphorylated Prolactin on Morphology and the Expression of Prostate Specific Genes in the Normal Rat Prostate The Prostate. Jan, 2003 | Pubmed ID: 12481252 Maternal Prolactin Composition Can Permanently Affect Epidermal GammadeltaT Cell Function in the Offspring Developmental and Comparative Immunology. Nov, 2002 | Pubmed ID: 12377224 Pseudophosphorylated Prolactin (S179D PRL) Inhibits Growth and Promotes Beta-casein Gene Expression in the Rat Mammary Gland Cell and Tissue Research. Sep, 2002 | Pubmed ID: 12195299 Cardiomyopathy in Zebrafish Due to Mutation in an Alternatively Spliced Exon of Titin Nature Genetics. Feb, 2002 | Pubmed ID: 11788825 An Intraperitoneal Injection Technique in Adult Zebrafish that Minimizes Body Damage and Associated Mortality JoVE 66500 Medicine Доксорубицин индуцированной кардиомиопатия модель в взрослых рыбок данио Xiao Ma*1,2,3, Yonghe Ding*2,3, Yong Wang2,3,4, Xiaolei Xu1,2,3 1Clinical and Translational Sciences Track, Mayo Clinic Graduate School of Biomedical Sciences, 2Department of Biochemistry and Molecular Biology, Mayo Clinic, 3Division of Cardiovascular Diseases, Mayo Clinic, 4Institute of Life Science, Beijing University of Chinese Medicine JoVE 57567 Medicine Иммуноокрашивание расчлененного данио рерио Эмбриональные сердца Jingchun Yang1, Xiaolei Xu1 1Division of Cardiovascular Diseases, Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine JoVE 3510 Biology
An Intraperitoneal Injection Technique in Adult Zebrafish that Minimizes Body Damage and Associated Mortality JoVE 66500 Medicine
Доксорубицин индуцированной кардиомиопатия модель в взрослых рыбок данио Xiao Ma*1,2,3, Yonghe Ding*2,3, Yong Wang2,3,4, Xiaolei Xu1,2,3 1Clinical and Translational Sciences Track, Mayo Clinic Graduate School of Biomedical Sciences, 2Department of Biochemistry and Molecular Biology, Mayo Clinic, 3Division of Cardiovascular Diseases, Mayo Clinic, 4Institute of Life Science, Beijing University of Chinese Medicine JoVE 57567 Medicine
Иммуноокрашивание расчлененного данио рерио Эмбриональные сердца Jingchun Yang1, Xiaolei Xu1 1Division of Cardiovascular Diseases, Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine JoVE 3510 Biology
