analysis-effect-compound-salt-stress-on-seed-germination-salt

Analysis of Effect of Compound Salt Stress on Seed Germination and Salt Tolerance Analysis of Pepper (<em>Capsicum annuum</em> L.)

To determine the salt tolerance and physiological mechanism of pepper (Capsicum annuum L.) at the germination stage, the Hongtianhu 101 and Xinxiang 8 ...

mannose-receptor-c-type-2-predicts-poor-outcome-glioma-is-associated

Mannose Receptor C Type 2 Predicts Poor Outcome in Glioma and is Associated With Invasive Phenotypes and &#946;-Catenin/EMT-related Changes

Glioma remains a lethal malignancy of the central nervous system, and additional biomarkers that improve prognostic stratification and inform therapeutic ...

Gannan Normal University

Medical school Vocational Technical College Yueyang

Breast cancer is an important cause of crisis for women's life and health. Voltage-dependent anion channel 1 (VDAC1) is mainly localized in the outer mitochondrial membrane of all eukaryotes, and it plays a crucial role in the cell as the main interface between mitochondria and cellular metabolism. Through bioinformatics, we found that VDAC1 is abnormally highly expressed in breast cancer, and the prognosis of breast cancer patients with high VDAC1 expression is poor. Through  and  experiments, we found that VDAC1 can promote the proliferation, migration and invasion of breast cancer cells. Further research we found that VDAC1 can activate the wnt signaling pathway. Through analysis, we found that miR-874-3p can regulate the expression of VDAC1, and the expression of miR-874-3p is decreased in breast cancer, resulting in the increase of VDAC1 expression. Our findings will provide new targets and ideas for the prevention and treatment of breast cancer.

miRNA-874-3p inhibits the migration, invasion and proliferation of breast cancer cells by targeting VDAC1.

Triple-negative breast cancer (TNBC) is the subtype of advanced breast cancer with the shortest survival time and the poorest prognosis, and treatment options are relatively limited. Exosomes, small extracellular vesicles enriched with bioactive molecules, are critical mediators of intercellular communication and have been implicated in cancer progression. The aim of this study was to investigate the molecular mechanism of exosomes promoting the proliferation and migration of TNBC.

ArticleTotal : 2	Year
Publication title Cited by 4	2022
Publication title	2026

Article	Year
miRNA-874-3p inhibits the migration, invasion and proliferation of breast cancer cells by targeting VDAC1. Aging\| PubMed ID: 36750173	2023
Tumor-derived exosomal lncRNA SNHG4 promotes triple-negative breast cancer progression by targeting XPO5. Frontiers in oncology\| PubMed ID: 40657248	2025

Zhiwen Wang

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