Zigang Li

Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School

Affiliated withPeking University Shenzhen Graduate School Shenzhen Bay laboratory

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 3	2018
Publication title	2022

Other Publications

Article	Year
A virus-like particle of the hepatitis B virus preS antigen elicits robust neutralizing antibodies and T cell responses in mice. Antiviral research\| PubMed ID: 29129705	2018
Iron homeostasis regulates the activity of the microRNA pathway through poly(C)-binding protein 2. Cell metabolism\| PubMed ID: 22633452	2012
Solution-processed photodetectors based on organic-inorganic hybrid perovskite and nanocrystalline graphite. Nanotechnology\| PubMed ID: 26978061	2016
E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes. Arthritis research & therapy\| PubMed ID: 27165343	2016
An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide. Angewandte Chemie (International ed. in English)\| PubMed ID: 27167181	2016
A Thioether-Stabilized d-Proline-l-Proline-Induced β-Hairpin Peptide of Defensin Segment Increases Its Anti-Candida albicans Ability. Chembiochem : a European journal of chemical biology\| PubMed ID: 27194395	2016
A proline-derived transannular N-cap for nucleation of short α-helical peptides. Chemical communications (Cambridge, England)\| PubMed ID: 27357119	2016
Constructing thioether-tethered cyclic peptides via on-resin intra-molecular thiol-ene reaction. Journal of peptide science : an official publication of the European Peptide Society\| PubMed ID: 27378284	2016
An in-tether sulfilimine chiral center induces helicity in short peptides. Chemical communications (Cambridge, England)\| PubMed ID: 27480995	2016
Structure-Based Identification of a Potent Inhibitor Targeting Stp1-Mediated Virulence Regulation in Staphylococcus aureus. Cell chemical biology\| PubMed ID: 27499528	2016
Crosslinked Aspartic Acids as Helix-Nucleating Templates. Angewandte Chemie (International ed. in English)\| PubMed ID: 27572954	2016
An in-tether sulfilimine chiral center induces β-turn conformation in short peptides. Organic & biomolecular chemistry\| PubMed ID: 27722542	2016
An in-tether sulfoxide chiral center influences the biophysical properties of the N-capped peptides. Bioorganic & medicinal chemistry\| PubMed ID: 27919612	2017
Improving cell penetration of helical peptides stabilized by N-terminal crosslinked aspartic acids. Organic & biomolecular chemistry\| PubMed ID: 27924991	2017
Switching substitution groups on the in-tether chiral centre influences backbone peptides' permeability and target binding affinity. Organic & biomolecular chemistry\| PubMed ID: 27929189	2017
Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity. Scientific reports\| PubMed ID: 27934919	2016
SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer. Theranostics\| PubMed ID: 28435453	2017
Dual In-Tether Chiral Centers Modulate Peptide Helicity. Bioconjugate chemistry\| PubMed ID: 28445034	2017
A precisely positioned chiral center in an i, i + 7 tether modulates the helicity of the backbone peptide. Chemical communications (Cambridge, England)\| PubMed ID: 28585955	2017
Reversible and Versatile On-Tether Modification of Chiral-Center-Induced Helical Peptides. Bioconjugate chemistry\| PubMed ID: 28650634	2017
Effect of Stapling Architecture on Physiochemical Properties and Cell Permeability of Stapled α-Helical Peptides: A Comparative Study. Chembiochem : a European journal of chemical biology\| PubMed ID: 28876512	2017
An in-tether chiral center modulates the proapoptotic activity of the KLA peptide. Chemical communications (Cambridge, England)\| PubMed ID: 28884757	2017
Development of a high quantum yield dye for tumour imaging. Chemical science\| PubMed ID: 28989666	2017
High-Throughput Screening Strategies for the Development of Anti-Virulence Inhibitors Against Staphylococcus Aureus. Current medicinal chemistry\| PubMed ID: 29165063	2017
N terminal N-methylation modulates chiral centre induced helical (CIH) peptides' biophysical properties. Chemical communications (Cambridge, England)\| PubMed ID: 29388647	2018
Achieving enhanced cell penetration of short conformationally constrained peptides through amphiphilicity tuning. Chemical science\| PubMed ID: 29568420	2017
Autophosphorylation Mechanism of the Ser/Thr Kinase Stk1 From . Frontiers in microbiology\| PubMed ID: 29731745	2018
Tuning peptide self-assembly by an in-tether chiral center. Science advances\| PubMed ID: 29756036	2018
Reversible stapling of unprotected peptides chemoselective methionine bis-alkylation/dealkylation. Chemical science\| PubMed ID: 29844896	2018
Evaluation of topologically distinct constrained antimicrobial peptides with broad-spectrum antimicrobial activity. Organic & biomolecular chemistry\| PubMed ID: 30004546	2018
Recent advances in peptidomimetics antagonists targeting estrogen receptor α-coactivator interaction in cancer therapy. Bioorganic & medicinal chemistry letters\| PubMed ID: 30025900	2018
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells . Cancer research\| PubMed ID: 30842103	2019
Autophagy inducing cyclic peptides constructed by methionine alkylation. Chemical communications (Cambridge, England)\| PubMed ID: 30896003	2019
Design and Synthetic Strategies for Helical Peptides. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 31134570	2019
A sulfonium tethered peptide ligand rapidly and selectively modifies protein cysteine in vicinity. Chemical science\| PubMed ID: 31183045	2019
α-Helical Motif as Inhibitors of Toxic Amyloid-β Oligomer Generation via Highly Specific Recognition of Amyloid Surface. iScience\| PubMed ID: 31255986	2019
Uncariitannin, a polyphenolic polymer from Uncaria gambier, attenuates Staphylococcus aureus virulence through an MgrA-mediated regulation of α-hemolysin. Pharmacological research\| PubMed ID: 31288080	2019
Directional assembly of a stapled α-helical peptide. Chemical communications (Cambridge, England)\| PubMed ID: 31414101	2019
Targeting the Amyloid-β Fibril Surface with a Constrained Helical Peptide Inhibitor. Biochemistry\| PubMed ID: 31702899	2020
A Sulfonium Triggered Thiol-yne Reaction for Cysteine Modification. The Journal of organic chemistry\| PubMed ID: 31899633
Intramolecular methionine alkylation constructs sulfonium tethered peptides for protein conjugation. Chemical communications (Cambridge, England)\| PubMed ID: 32124910	2020
Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension. Emerging microbes & infections\| PubMed ID: 32228222	2020
Organosilicon modification to enhance the stability of black phosphorus nanosheets under ambient conditions. Journal of materials chemistry. B\| PubMed ID: 32255150	2018
Dual-acidity-labile polysaccharide-di-drugs conjugate for targeted cancer chemotherapy. European journal of medicinal chemistry\| PubMed ID: 32474350	2020
An overview of the safety, clinical application and antiviral research of the COVID-19 therapeutics. Journal of infection and public health\| PubMed ID: 32684351	2020
Structural insights into the inhibition of bacterial RecA by naphthalene polysulfonated compounds. iScience\| PubMed ID: 33458611	2021
Molecular design of stapled pentapeptides as building blocks of self-assembled coiled coil-like fibers. Science advances\| PubMed ID: 33523941	2021
SOD1 is a Possible Predictor of COVID-19 Progression as Revealed by Plasma Proteomics. ACS omega\| PubMed ID: 34250342	2021
Facile Chemoselective Modification of Thioethers Generates Chiral Center-Induced Helical Peptides. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 34386967	2021
Potent Inhibition of HIF1α and p300 Interaction by a Constrained Peptide Derived from CITED2. Journal of medicinal chemistry\| PubMed ID: 34472840	2021
Helical Stabilization of Peptide Macrocycles by Stapled Architectures. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 34596860	2022
Novel Strategies in C-H Oxidations for Natural Product Diversification-A Remote Functionalization Application Summary. Frontiers in chemistry\| PubMed ID: 34676198	2021
Tetrahedral DNA nanostructure based biosensor for high-performance detection of circulating tumor DNA using all-carbon nanotube transistor. Biosensors & bioelectronics\| PubMed ID: 34800925	2022
Electrophilic Sulfonium-Promoted Peptide and Protein Amidation in Aqueous Media. Organic letters\| PubMed ID: 34968069	2022
Design and Evaluation of a Novel Peptide-Drug Conjugate Covalently Targeting SARS-CoV-2 Papain-like Protease. Journal of medicinal chemistry\| PubMed ID: 34981929	2022
Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30. Autophagy\| PubMed ID: 34989313	2022
Sulfonium Triggered Alkyne-Azide Click Cycloaddition. Organic letters\| PubMed ID: 35156827	2022
Chemo-Selective Cys-Pen Disulfide for Proximity-Induced Cysteine Cross-Linking. ACS chemical biology\| PubMed ID: 35225603	2022
Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Analytical chemistry\| PubMed ID: 35244395	2022
A novel inhibitor of -methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities. Acta pharmaceutica Sinica. B\| PubMed ID: 35256950	2022
Computational elucidation of the binding mechanisms of curcumin analogues as bacterial RecA inhibitors. RSC advances\| PubMed ID: 35519399	2019
Whole-body PET tracking of a d-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors. Acta pharmaceutica Sinica. B\| PubMed ID: 35530129	2022
Flavin catalyzed desulfurization of peptides and proteins in aqueous media. Organic & biomolecular chemistry\| PubMed ID: 35546316	2022
Diversity-Oriented Synthesis of ERα Modulators via Mitsunobu Macrocyclization. Organic letters\| PubMed ID: 35546524	2022
Therapeutic potential for amyloid surface inhibitor: only amyloid-β oligomers formed by secondary nucleation disrupt lipid membrane integrity. The FEBS journal\| PubMed ID: 35670622	2022
Sulfonium-Tethered Peptide. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 35761049	2022
Histidine-specific bioconjugation visible-light-promoted thioacetal activation. Chemical science\| PubMed ID: 35919717	2022
Structure-Based Design, Optimization, and Evaluation of Potent Stabilized Peptide Inhibitors Disrupting MTDH and SND1 Interaction. Journal of medicinal chemistry\| PubMed ID: 36044768	2022
Biodistribution, degradability and clearance of 2D materials for their biomedical applications. Chemical Society reviews\| PubMed ID: 36047060	2022
Universal DNA detection realized by peptide based carbon nanotube biosensors. Nanoscale advances\| PubMed ID: 36133222	2020
A Peptide-Based Ligand-Directed Chemistry Enables Protein Functionalization. Organic letters\| PubMed ID: 36169233	2022