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Isolation and Characterization of Bone Marrow Microenvironment in Myeloid Neoplasms

November 10th, 2023
1,2, 1,3, 1,3, 1,2, 1,3,4, 1,5, 1,3
1Wilmot Cancer Institute, University of Rochester Medical Center, 2Department of Biomedical Engineering, University of Rochester, 3Department of Biomedical Genetics, University of Rochester Medical Center, 4Genomics Research Center, University of Rochester Medical Center, 5Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center

Summary
Automatic Translation

Her præsenteres en detaljeret protokol til isolering og karakterisering af knoglemarvsmikromiljøpopulationer fra murine modeller af myelodysplastiske syndromer og akut myeloid leukæmi. Denne teknik identificerer ændringer i den ikke-hæmatopoietiske knoglemarvsniche, herunder endotel- og mesenkymale stromale celler, med sygdomsprogression.

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