Overview
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular filtration, they can be quickly reabsorbed from the glomerular filtrate back into the bloodstream through tubular reabsorption processes. This rapid reabsorption leads to an accumulation of the drug in the body, extending its effects and potentially triggering toxic reactions. To counteract this issue, lipophilic drugs undergo a biochemical transformation known as biotransformation or metabolism. Lipophilic drugs are chemically modified during metabolism into hydrophilic (water-soluble) derivatives. This transformation increases their solubility in water and facilitates their efficient elimination from the body via urine. While various bodily tissues can metabolize drugs, the liver is primarily responsible for this biotransformation. Within the liver, specialized enzymes catalyze the biotransformation process. Drug biotransformation involves two main enzymatically catalyzed reactions that occur sequentially. Phase I reactions are catabolic reactions that involve the functionalization …
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Embed code vs URL
An embed code allows you to place a JoVE video directly inside of your learning or training environment. Most learning management systems such as Canvas, Blackboard, and Moodle require an embed code for JoVE content to stream.
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Most of the time, you will want to use the embed code. However, there are some environments that don’t support embed codes such as Google Classrooms and MS Teams. In those instances, you can use a URL to still provide access to JoVE videos.
What is an Embed Code?
Basically, it’s a snippet of code that you put on your website that displays as a video. An embed code pulls the video from the original source, allowing you to display a video without having to host the file on your website.
How to embed a video
STEP 1: COPY YOUR EMBED CODE
To generate the embed code, simply click the Copy button above. You can customize it by choosing a specific language for the video, or setting exact dimensions for the video player.
STEP 2: PASTE THE EMBED CODE INTO YOUR ENVIRONMENT
Embed codes can be used in most learning management systems (Canvas, Blackboard, Moodle…), organizational websites, and a host of other tools. The specifics of how to add in an embed code will depend on your environment.
Generally, it involves accessing a text editor, entering the HTML mode on the editor, and pasting in the embed code. Get more details on embedding into specific environments here.