The Academic College of Tel-Aviv-Yaffo 2 articles published in JoVE Behavior The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice Or Burstein1, Ravid Doron1,2 1School of Behavioral Science, The Academic College Tel-Aviv-Yaffo, 2Department of Education and Psychology, Open University Here we present the unpredictable chronic mild stress protocol in mice. This protocol induces a long-term depressive-like phenotype and enables to assess the efficacy of putative antidepressants in reversing the behavioral and neuromolecular depressive-like deficits. Behavior The Forced Swim Test as a Model of Depressive-like Behavior Roni Yankelevitch-Yahav1,2, Motty Franko2, Avrham Huly2, Ravid Doron2,3,4 1School of Psychological Sciences, Tel-Aviv University, 2School of Behavioral Sciences, Academic College of Tel Aviv-Yaffo, 3Department of Education and Psychology, The Open University of Israel, 4School of Health and Life Sciences, Hadassah Academic College This protocol describes the forced swim test, which is used for the study of depressive-like behavior in rodents. This procedure involves placing an animal in a container filled with water that eventually will lead to the exhibition of immobility behavior, which is considered to reflect behavioral despair.
