Center for Cellular and Molecular Biology 1 article published in JoVE Medicine Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen Preeti Sahay1, Kshama Jain1, Prakriti Sinha1, Barun Das1, Alaknanda Mishra1, Ashwani Kesarwani1, Parul Sahu1, K. Varsha Mohan1, M.J. Mahesh Kumar2, Perumal Nagarajan1, Pramod Upadhyay1 1National Institute of Immunology, 2Center for Cellular and Molecular Biology The acute liver failure animal model developed in the current study presents a feasible alternative for the study of potential therapies. The current model employs the combined effect of physical and drug-induced hepatic injury and provides a suitable time window to study the potential of novel therapies.
