CSIR-Institute of Genomics and Integrative Biology 1 article published in JoVE Biology Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish Babita Sharma*1,2, Yogaspoorthi J. Subramaniam*1,2, Desingu Ayyappa Raja1,2,3, Ayush Aggarwal1,2, Sridhar Sivasubbu1, Vivek T. Natarajan1,2 1CSIR-Institute of Genomics and Integrative Biology, 2Academy of Scientific and Innovative Research, 3Division of Biology and Biological Engineering, California Institute of Technology Regulators of melanocyte functions govern visible differences in the pigmentation outcome. Deciphering the molecular function of the candidate pigmentation gene poses a challenge. Herein, we demonstrate the use of a zebrafish model system to identify candidates and classify them into regulators of melanin content and melanocyte number.
