University of Tasmania 1 article published in JoVE Chemistry Employing Pressurized Hot Water Extraction (PHWE) to Explore Natural Products Chemistry in the Undergraduate Laboratory Curtis C. Ho1, Bianca J. Deans*1, Jeremy Just*1, Gregory G. Warr2, Shane Wilkinson2, Jason A. Smith1, Alex C. Bissember1 1School of Natural Sciences - Chemistry, University of Tasmania, 2School of Chemistry, The University of Sydney Here, we employ a pressurized hot water extraction (PHWE) method, which utilizes an unmodified household espresso machine to introduce undergraduates to natural products chemistry in the laboratory. Two experiments are presented: PHWE of eugenol and acetyleugenol from cloves and PHWE of seselin and (+)-epoxysuberosin from the Australian plant Correa reflexa.