Center of Plant Systems Biology and Biotechnology 1 article published in JoVE Biochemistry Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization Mustafa Bulut1, Alisdair R. Fernie1,2, Saleh Alseekh1,2 1Max-Planck-Institute of Molecular Plant Physiology, 2Center of Plant Systems Biology and Biotechnology In this protocol, we present an optimized workflow, which combines an efficient and fast sample preparation of many samples. In addition, we provide a step-by-step guide to reduce analytical variations for high-throughput evaluation of metabolic GWAS studies.