Friedrich-Schiller University 1 article published in JoVE Chemistry Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids Christopher Mayer-Bacon1, Mehmet Aziz Yirik2 1Biological Sciences Department, University of Maryland-Baltimore County, 2Institute for Inorganic and Analytical Chemistry, Friedrich-Schiller University The purpose of this protocol is to efficiently generate and curate small-molecule structure libraries using open-source software.