Medical School Berlin 1 article published in JoVE Biology Cell-Based Drug Screening for Inhibitors of Autophagy Related 4B Cysteine Peptidase Denise R. B. Pilger1, Christin Luft1, Robin Ketteler1,2 1Laboratory for Molecular Cell Biology, University College London, 2Department of Human Medicine, Medical School Berlin Here, we describe a detailed protocol for the use of a luciferase-based reporter assay in a semi-automated, high-throughput screening format.