Universidad de Murcia 3 articles published in JoVE Medicine Transthoracic Echocardiographic Examination in the Rabbit Model Alejandro Giraldo*1, Jesús Talavera López*2, Gavin Brooks1, María Josefa Fernández-del-Palacio2 1Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, 2Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad de Murcia Here we describe, step by step, a detailed protocol for performing echocardiography in the rabbit model. We show how to correctly obtain the different echocardiographic views and imaging planes, as well as the different imaging modes available in a clinical echocardiography system routinely used in human and veterinary patients. Medicine Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model Alejandro Giraldo*1, Jesús Talavera López*2, Maria Josefa Fernandez-Del-Palacio2, Obdulio García-Nicolás3,4, Juan Seva4, Gavin Brooks1, José María Moraleda5 1Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, 2Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad de Murcia, 3Institute of Virology and Immunology (IVI), 4Departamento de Anatomía y Anatomía Comparada, Facultad de Veterinaria, Universidad de Murcia, 5Unidad de Trasplante Hematopoyético y Terapia Celular, Departamento de Hematología, Hospital Universitario Virgen de la Arrixaca, IMIB, Universidad de Murcia Novel therapeutic strategies in cardiac regenerative medicine require extensive and detailed studies in large preclinical animal models before they can be considered for use in humans. Here, we demonstrate a percutaneous contrast echocardiography-guided intramyocardial injection technique in rabbits, which is valuable for hypothesis testing the efficacy of such novel therapies. Medicine Ultrasonography in Experimental Reproductive Investigations on Rats Tianjuang Wang1,2, Lidia Oltra-Rodríguez3, Nuria García-Carrillo3, Anibal Nieto4,5, Yunxia Cao*1,2,6, María L. Sánchez-Ferrer*4,5 1Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, 2Institute of Reproductive Genetics, Anhui Medical University, 3Centro Experimental en Investigaciones Biomédica (CEIB), Campus Ciencias de la Salud, Universidad de Murcia, 4Department of Obstetrics and Gynecology, 'Virgen de la Arrixaca' University Clinical Hospital, 5Institute for Biomedical Research of Murcia, IMIB-Arrixaca, 6Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs This manuscript describes the utility of ultrasound performed on female rats to design experimental models for reproductive and gynecological investigation. A step-by-step explanation of how to perform ultrasonographic evaluation is shown.
