CHU Montpellier 1 article published in JoVE Immunology and Infection In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells Michel Jourdan1, Hugues de Boussac1, Elena Viziteu1, Alboukadel Kassambara1, Jérôme Moreaux1,2,3 1IGH, CNRS, Univ Montpellier, 2Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology, CHU Montpellier, 3UFR de Médecine, Univ Montpellier Using multi-step culture systems, we report an in vitro B cell to plasma cell differentiation model.