Rouen Institute for Research and Innovation in Biomedicine (IRIB) 1 article published in JoVE Neuroscience Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage Martin Pedard1, Mohamad El Amki1, Antoine Lefevre-Scelles1,2, Vincent Compère1,2, Hélène Castel1 1University of Rouen Normandy, INSERM U1239, DC2N, Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France, 2Department of Anesthesiology and Critical Care, Rouen University Hospital, Rouen, France We described in this protocol a standardized subarachnoid hemorrhage (SAH) mouse model by a double injection of autologous whole-blood into the cisterna magna. The high degree of standardization of the double-injection procedure represents a middle-to-acute model of SAH with relative safety regarding mortality.
