CFD Research Corporation 2 articles published in JoVE Bioengineering A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation Qingliang Yang1, Jordan C. Langston2, Yuan Tang3, Balabhaskar Prabhakarpandian4, Laurie E. Kilpatrick5, Mohammad F. Kiani1,2,6 1Department of Mechanical Engineering, Temple University, 2Department of Bioengineering, Temple University, 3Department of Bioengineering, University of Toledo, 4Biomedical Technology, CFD Research Corporation, 5Center for Inflammation and Lung Research, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine, Temple University, 6Department of Radiation Oncology, Lewis Katz School of Medicine, Temple University In this protocol, a biomimetic microfluid assay, which can reproduce a physiologically relevant microvascular environment and reproduce the entire leukocyte adhesion/migration cascade, is employed to study leukocyte-endothelial cell interactions in inflammatory disease. Bioengineering Generation of Shear Adhesion Map Using SynVivo Synthetic Microvascular Networks Ashley M. Smith1, Balabhaskar Prabhakarpandian1, Kapil Pant1 1Biomedical Technology, CFD Research Corporation Flow chambers used in adhesion experiments typically consist of linear flow paths and require multiple experiments at different flow rates to generate a shear adhesion map. SynVivo-SMN enables the generation of shear adhesion map using a single experiment utilizing microliter volumes resulting in significant savings in time and consumables.
