Veterans Affairs Medical Center and University of California, San Francisco 1 article published in JoVE Cancer Research Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients Divya Bhagirath1, Rajvir Dahiya2, Shahana Majid2, Z. Laura Tabatabai3, Sharanjot Saini1 1Department of Biochemistry and Molecular Biology, Augusta University, 2Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, 3Department of Pathology, Veterans Affairs Medical Center and University of California, San Francisco Therapy resistance often develops in patients with advanced prostate cancer, and in some cases, cancer progresses to a lethal subtype called neuroendocrine prostate cancer. Assessing the small non-coding RNA-mediated molecular changes that facilitate this transition would allow better disease stratification and identification of causal mechanisms that lead to development of neuroendocrine prostate cancer.
