Hilltop Lab Animals Inc 1 article published in JoVE Medicine Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology Christian J. Miedel1, Jennifer M. Patton1, Andrew N. Miedel1, Edward S. Miedel1, Jonathan M. Levenson2 1Hilltop Laboratory Animals, 2Preclinical Research & Development, Proclara Biosciences, Inc. Described here is a staged, behavioral screening approach that can be used to screen for compounds that exhibit in vivo efficacy on cognitive and functional motor behaviors in transgenic mouse models of β-amyloidosis and tauopathy. These methods are optimized to screen compounds for activity in short-term and working memory tasks.
