University of Houston College of Pharmacy 1 article published in JoVE Immunology and Infection A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment Bradley Endres1, Eugénie Bassères1, Tasnuva Rashid1, Long Chang2, M. Jahangir Alam1, Kevin W Garey1 1Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, 2Department of Electrical and Computer Engineering, University of Houston Antibiotic efficacy is most commonly determined by conducting killing kinetic studies and measuring colony forming units (CFUs). By integrating scanning electron microscopy (SEM) with these standard methods, we can distinguish the pharmacological effects of treatment between different antibiotics.
