South Texas Veteran's Health Care System 1 article published in JoVE Behavior The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice Jillian M. Heisler1, Juan Morales1, Jennifer J. Donegan1, Julianne D. Jett1, Laney Redus1, Jason C. O'Connor1,2 1Department of Pharmacology, University of Texas Health Science Center at San Antonio, 2 The goal of this protocol is to perform a behavioral assay such as the attentional set shifting task (AST) to assess prefrontal cortex-mediated cognitive flexibility in mice.