Clark Atlanta University View Institution's Website 1 article published in JoVE Biology Procedure for Fabricating Biofunctional Nanofibers Jereme Doss1, Omotunde Olubi1, Biswajit Sannigrahi1, M. D. Williams2, Deepti Gadi3, Barbara Baird3, Ishrat Khan1 1Department of Chemistry, Clark Atlanta University, 2Department of Physics, Clark Atlanta University, 3Department of Chemistry and Chemical Biology, Cornell University An efficient approach for preparing nanofibers decorated with functional groups capable of specifically interacting with proteins is described. The approach first requires the preparation of a polymer functionalized with the appropriate functional group. The functional polymer is fabricated into nanofibers by electrospinning. The effectiveness of the binding of the nanofibers with a protein is studied by confocal microscopy.