Albert Einstein College of Medicine/Montefiore Medical Center 2 articles published in JoVE Cancer Research Stabilized Window for Intravital Imaging of the Murine Pancreas Jakeb Petersen*1,2,3, Wei Du*4,5, Christian Adkisson1,4, Claudia Gravekamp6,7, Maja H. Oktay2,3,4,7,8,9, John Condeelis1,3,4,7,8,9,10, Nicole C. Panarelli2,3,7, John C. McAuliffe1,2,3,7,8, David Entenberg2,3,4,7,8,9 1Department of Surgery, Einstein College of Medicine / Montefiore Medical Center, 2Department of Pathology, Einstein College of Medicine / Montefiore Medical Center, 3Integrated Imaging Program for Cancer Research, Einstein College of Medicine / Montefiore Medical Center, 4Department of Anatomy and Structural Biology, Einstein College of Medicine / Montefiore Medical Center, 5 We present a protocol for the surgical implantation of a stabilized indwelling optical window for subcellular-resolution imaging of the murine pancreas, allowing serial and longitudinal studies of the healthy and diseased pancreas. Cancer Research Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion Madeline Friedman-DeLuca1,2, Prachiben P. Patel1,2, Burcu Karadal-Ferrena1,2, Nicole D. Barth1,2, Camille L. Duran1,2, Xianjun Ye1,2,3, Michael Papanicolaou2,4, John S. Condeelis2,3,4,5,6,7, Maja H. Oktay1,2,3,5,6,7, Lucia Borriello*1,2,8, David Entenberg*1,2,3,5,6 1Department of Pathology, Albert Einstein College of Medicine/Montefiore Medical Center, 2Cancer Dormancy and Tumor Microenvironment Institute, Albert Einstein College of Medicine/Montefiore Medical Center, 3Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, 4Department of Cell Biology, Albert Einstein College of Medicine/Montefiore Medical Center, 5Montefiore Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center, 6Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine/Montefiore Medical Center, 7Department of Surgery, Albert Einstein College of Medicine/Montefiore Medical Center, 8Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Fox Chase Cancer Center We present a method for studying tumor cell redissemination from lung metastases involving a surgical protocol for the selective photoconversion of lung metastases, followed by the identification of redisseminated tumor cells in tertiary organs.
