Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Click here for the English version

Neuroscience

سريع تحديد العتبة Nociceptive الحرارية في الفئران المصابة بمرض السكر

Published: May 17, 2012 doi: 10.3791/3785

Materials

Name Company Catalog Number Comments
Incremental Hot-Plate Analgesia Meter IITC Inc. Life Science Part #PE34
Soft Series 8 IITC Inc. Life Science Part # Series8
Streptozotocin Calbiochem 572201

DOWNLOAD MATERIALS LIST

References

  1. Baron, R. Peripheral neuropathic pain: From mechanisms to symptoms. Clin. J. Pain. 16, S12-S20 (2000).
  2. Calcutt, N. A., Jorge, M. C., Yaksh, T. L., Chaplan, S. R. Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: Effects of insulin, aldose reductase inhibition and lidocaine. Pain. 68, 293-299 (1996).
  3. Bolcskei, K., Petho, G., Szolcsanyi, J. Noxious heat threshold measured with slowly increasing temperatures: Novel rat thermal hyperalgesia models. Methods Mol. Biol. 617, 57-66 (2010).
  4. Ankier, S. I. New hot plate tests to quantify antinociceptive and narcotic antagonist activities. Eur. J. Pharmacol. 27, 1-4 (1974).
  5. Almasi, R., Petho, G., Bolcskei, K., Szolcsanyi, J. Effect of resiniferatoxin on the noxious heat threshold temperature in the rat: A novel heat allodynia model sensitive to analgesics. Br. J. Pharmacol. 139, 49-58 (2003).
  6. Bolcskei, K., Horvath, D., Szolcsanyi, J., Petho, G. Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: A novel rat thermal hyperalgesia model. Eur. J. Pharmacol. 564, 80-87 (2007).
  7. Chesler, E. J., Wilson, S. G., Lariviere, W. R., Rodriguez-Zas, S. L., Mogil, J. S. Identification and ranking of genetic and laboratory environment factors influencing a behavioral trait, thermal nociception, via computational analysis of a large data archive. Neurosci. Biobehav. Rev. 26, 907-923 (2002).
  8. Langford, D. J., Crager, S. E., Shehzad, Z., Smith, S. B., Sotocinal, S. G., Levenstadt, J. S., Chanda, M. L., Levitin, D. J., Mogil, J. S. Social modulation of pain as evidence for empathy in mice. Science. 312, 1967-1970 (2006).
  9. Hunt, S. P., Koltzenburg, M. The neurobiology of pain. , Oxford University Press. New York. (2005).
  10. Willis, W. D. The pain system : The neural basis of nociceptive transmission in the mammalian nervous system. , Basel, New York, Karger. (1985).
  11. Calcutt, N. Modeling diabetic sensory neuropathy in rats. In: Methods in molecular medicine. Pain research: Methods and protocols. , Humana Press. Totowa, N.J. (2004).
  12. Bars, D. L. e, Gozariu, M., Cadden, S. W. Animal models of nociception. Pharmacol. Rev. 53, 597-652 (2001).
  13. Shaikh, A. S., Somani, R. S. Animal models and biomarkers of neuropathy in diabetic rodents. Indian J. Pharmacol. 42, 129-134 (2010).
  14. Hargreaves, K., Dubner, R., Brown, F., Flores, C., Joris, J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 32, 77-88 (1988).
  15. Hardy, J. D. Method for the rapid measurement of skin temperature during exposure to intense thermal radiation. J. Appl. Physiol. 5, 559-566 (1953).
  16. Sumino, R., Dubner, R., Starkman, S. Responses of small myelinated "warm" fibers to noxious heat stimuli applied to the monkey's face. Brain Res. 62, 260-263 (1973).
  17. Hammond, D. L., Ruda, M. A. Developmental alterations in thermal nociceptive threshold and the distribution of immunoreactive calcitonin gene-related peptide and substance p after neonatal administration of capsaicin in the rat. Neurosci. Lett. 97, 57-62 (1989).
سريع تحديد العتبة Nociceptive الحرارية في الفئران المصابة بمرض السكر
Play Video
PDF DOI DOWNLOAD MATERIALS LIST

Cite this Article

Alshahrani, S., Fernandez-Conti, F., More

Alshahrani, S., Fernandez-Conti, F., Araujo, A., DiFulvio, M. Rapid Determination of the Thermal Nociceptive Threshold in Diabetic Rats. J. Vis. Exp. (63), e3785, doi:10.3791/3785 (2012).

Less
Copy Citation Download Citation Reprints and Permissions
View Video

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter