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JoVE Journal Neuroscience
Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
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Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

Article DOI: 10.3791/1955-v • 15:23 min • May 13th, 2010
May 13th, 2010 •
1, 1,2,3
1Department of Neurology, David Geffen School of Medicine, 2Molecular Biology Institute, University of California, Los Angeles, 3Brain Research Institute, University of California, Los Angeles

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Aptamers are short ribo-/deoxyribo-oligonucleotides selected by in-vitro evolution methods based on affinity for a specific target. Aptamers are molecular recognition tools with versatile therapeutic, diagnostic, and research applications. We demonstrate methods for selection of aptamers for amyloid β-protein, the causative agent of Alzheimer's disease.

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Aptamers Amyloid β-protein Alzheimer's Disease Neurodegenerative Disorder Presymptomatic Diagnosis Early Diagnosis Effective Therapies Aβ Assemblies Synaptic Dysfunction Neuron Loss AD Etiology AD Pathogenesis Molecular Recognition Tools Antibodies Aptamers Advantages SELEX (systematic Evolution Of Ligands By Exponential Enrichment)
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