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Laser Capture Microdissection of Oral Submucous Fibrosis Tissues for Morphology and Spatial Information Analysis (Video) | JoVE
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Laser Capture Microdissection of Oral Submucous Fibrosis Tissues for Morphology and Spatial Information Analysis (Video) | JoVE

Capturing Oral Submucous Fibrosis Tissue Samples for Spatial-Omics Analysis

Article DOI: 10.3791/200509-v • 02:12 min • August 11th, 2023
August 11th, 2023 •
1,2, 3, 1,2, 1,2
1Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, 2Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions, Chinese Academy of Medical Sciences (2019RU034), 3Central Laboratory, Peking University School and Hospital of Stomatology

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Isolation Cells Morphological Information Spatial Information Oral Submucous Fibrosis Samples Laser Capture Microdissection Potentially Malignant Disorder Atrophy Epithelium Fibrosis Lamina Propria Submucosa Histopathological Slides Epithelial Dysplasia Senescent Fibroblasts Malignant Transformation Molecular Mechanisms Heterogeneity Oral Squamous Cell Carcinoma Specific Molecular Mechanisms Formalin-fixed Paraffin-embedded Tissue Slides Microscope Microscale Dysplastic Tissue Atrophic Epithelial Tissue Fibrotic Subepithelial Tissue Genome Sequencing Transcriptome Sequencing Genomic Data Transcriptomic Data
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