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JoVE Encyclopedia of Experiments
Encyclopedia of Experiments: Cancer Research

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Tumor Treating Fields Application in Human Brain Tumor Models: A Non-invasive Technique to Deliver Alternating Electric Fields to Human Brain for Treating Brain Tumor

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Transcript

The TTF system is composed of the following instruments: a portable battery, a connection cable and box, an electric field generator, a plug-in power supply, and a set of transducer arrays.

To assemble the TTF system, charge the battery by placing it in the charger, plugging in the charger to a wall outlet, and turning on the power button on the back of the charger.

Once the battery has been charged, plug the battery into the electric field generator then through its connector to a socket labeled "DC IN" on the front panel of the device. Ensure that the arrows on the battery connector are facing up towards the "DC IN" sign while plugging in the connector.

Then, using the black and white color-coded plugs, connect each of the four transducer array connectors to the matching black and white color-coded sockets on the connection cable box. Insert the cable from the connection box to the connection cable socket on the device.

To apply the transducer array, begin by using an electric shaver to shave the patient's entire scalp, ensuring that no stubble remains. Then, use 70% medical-grade alcohol to wipe the scalp.

Next, remove the transducer arrays from the envelopes. Then, to the patient's clean scalp, apply each of the arrays according to a predetermined specific array arrangement. Plug the array cables into the color-matched connection cable and box.

After the arrays are in place and the system is fully connected, turn on the power switch on the device. Then, switch on the TTF field button. The system is now ready for electric field delivery.

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