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Studying the Effects of Matrix Stiffness on Cellular Function using Acrylamide-based Hydrogels
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Studying the Effects of Matrix Stiffness on Cellular Function using Acrylamide-based Hydrogels

Article DOI: 10.3791/2089-v • 10:20 min • August 10th, 2010
August 10th, 2010 •
1, 1, 1
1Department of Pharmacology, University of Pennsylvania

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The effect of substrata stiffness on cellular function can be modeled in vitro using polyacrylamide hydrogels of varying compliances.

Tags

Matrix Stiffness Cellular Function Acrylamide-based Hydrogels Tissue Stiffness Fibrosis Cancer Cardiovascular Disease Cell Biology ECM-coated Hydrogels Polyacrylamide NaOH 3-APTMS Glutaraldehyde Acrylamide (AC) Bis-acrylamide (Bis-AC) Ammonium Persulfate N-hydroxysuccinimide (NHS) Rheology Atomic Force Microscopy (AFM)
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