JoVE Journal
Bioengineering
Bioengineering
This content is Open Access.
Chapters
Summary
Please note that all translations are automatically generated.
A tapping mode atomic force microscope (AFM) method for the visualization of plasmid DNA, cytoplasmic proteins, and DNA-protein complexes is described. The method includes alternate approaches for preparing samples for AFM imaging following biochemical manipulation. DNA containing specific protein interacting regions are observed in near-physiologic buffer conditions.